A common heterocyclic compound, the chiral-catalyst compound, name is (S)-2-(Methoxymethyl)pyrrolidine,cas is 63126-47-6, mainly used in chemical industry, its synthesis route is as follows.,63126-47-6
EXAMPLE 10 ; 8-12-[2-(2-(S)-Methoxymethyl-pyrrolidin-1-yl)-ethyl]-benzofuran-5-yl)-6,7-dihydro-5H-1,4,8a-triaza-s-indacene: Methanesulfonic acid 2-[5-(6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-benzo-furan-2-yl]-ethyl ester (0.085 mmol) described above was dissolved in acetonitrile (2 ml) followed by addition of 2-(S)-methoxymethylpyrrolidine (0.85 mmol) and potassium carbonate (0.425 mmol) and heated to 70¡ã C. for 24 hours. The reaction was cooled, filtered and concentrated. The residue was purified via preparative HPLC to give the title compound. [M+1]+ calc’d for C25H29N4O2, 417; found, 417.
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Reference£º
Patent; Athersys, Inc.; US2006/9451; (2006); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare