A common heterocyclic compound, the chiral-catalyst compound, name is D-Phenylalanine,cas is 673-06-3, mainly used in chemical industry, its synthesis route is as follows.,673-06-3
EXAMPLE 1 (R)-2-Bromo-3-phenylpropanoic Acid Sodium nitrite (27 g in water) is added at 0 C. to a solution of D-phenylalanine (40 g) in a mixture of 48% hydrobromic acid/water (1:1 by volume). The mixture is stirred for 30 minutes at 0 C. and then for 2 hours 30 minutes at a temperature close to 0 C. The reaction mixture is extracted with ether. The organic extracts are washed with water and a saturated sodium chloride solution and then dried over sodium sulphate. After filtration and concentration to dryness, the obtained residue is purified by distillation. (R)-2-Bromo-3-phenylpropanoic acid (33 g) is obtained which has the following characteristics: B.p.1kPa =154 C.; Rf =0.47 (methylene chloride/methanol). The yield is 60%.
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Reference£º
Patent; Institut National de la Sante et de la Recherche Medicale (INSERM); US5591891; (1997); A;,
Chiral Catalysts
Chiral catalysts – SlideShare