Awesome and Easy Science Experiments about 4254-14-2

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 4254-14-2 help many people in the next few years. Name: (R)-Propane-1,2-diol.

4254-14-2, Name is (R)-Propane-1,2-diol, molecular formula is C3H8O2, Name: (R)-Propane-1,2-diol, belongs to chiral-catalyst compound, is a common compound. In a patnet, author is Liu, Jian-Biao, once mentioned the new application about 4254-14-2.

The 3d transition metal-catalyzed enantioselective C-H functionalization provides a sustainable strategy for the construction of chiral molecules. A better understanding of the catalytic nature of the reactions and the factors controlling the enantioselectivity is important for rational design of more efficient systems. Herein, the mechanisms of Ni-catalyzed enantioselective C-H cyclization of imidazoles are investigated by density functional theory (DFT) calculations. Both the pi-allyl nickel(II)-promoted sigma-complex-assisted metathesis (sigma-CAM) and the nickel(0)-catalyzed oxidative addition (OA) mechanisms are disfavored. In addition to the typically proposed ligand-to-ligand hydrogen transfer (LLHT) mechanism, the reaction can also proceed via an unconventional sigma-CAM mechanism that involves hydrogen transfer from the JoSPOphos ligand to the alkene through P-H oxidative addition/migratory insertion, C(sp(2))-H activation via sigma-CAM, and C-C reductive elimination. Importantly, computational results based on this new mechanism can indeed reproduce the experimentally observed enantioselectivities. Further, the catalytic activity of the pi-allyl nickel(II) complex can be rationalized by the regeneration of the active nickel(0) catalyst via a stepwise hydrogen transfer, which was confirmed by experimental studies. The calculations reveal several significant roles of the secondary phosphine oxide (SPO) unit in JoSPOphos during the reaction. The improved mechanistic understanding will enable design of novel enantioselective C-H transformations.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 4254-14-2 help many people in the next few years. Name: (R)-Propane-1,2-diol.

Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare