The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Chloroethyl acetate, is researched, Molecular C4H7ClO2, CAS is 542-58-5, about Alkylation of acetylcholinesterase anionic center with aziridinium ion accelerates the enzyme acylation step, the main research direction is acetylcholinesterase derivative acetate ester hydrolysis QSAR.Recommanded Product: 2-Chloroethyl acetate.
Affinity labeling of the acetylcholinesterase (EC 3.1.1.7) anionic center with N,N-dimethyl-2-phenylaziridinium ion accelerated the hydrolysis of nonionic acetic esters by increasing the rate of the enzyme acylation step ≥500-fold, whereas the rate of the deacylation step remains unchanged. Simultaneously, a ≥10-fold decrease in substrate binding affinity took place. The acceleration phenomenon could be explained by the induced-fit mechanism as the binding of the cationic label to the enzyme anionic site brings the esteratic center into a conformation which provides extra stabilization for the transition state of the enzyme acylation reaction, probably by a more close structural fit between the substrate mol. and the enzyme active center.
This compound(2-Chloroethyl acetate)Recommanded Product: 2-Chloroethyl acetate was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.