In an article, published in an article, once mentioned the application of 1806-29-7, Name is 2,2-Biphenol,molecular formula is C12H10O2, is a conventional compound. this article was the specific content is as follows.Computed Properties of C12H10O2
Reaction of 1,1?-binaphthol and structurally related 1,1?-biphenols with sulfonylating reagents [RSO2Cl; R = 4-Tol, Ph] leads to clean, ultraselective monoderivatisation, shown crystallographically in one case (2-OH-2?-OTs-1,1?-binaphthyl). Reaction of the remaining 2-hydroxy function with either Tf2O or NfF [Nf = nonaflate, CF3(CF2)3SO2-] affords the protected/activated cores (2-R1O-2?-R 2O-1,1?-biaryl) [R1,R2 pairs = Tf,Ts (X-ray); Tf,SO2Ph; Nf,Ts (on 1,1?-binaphthyl core); Tf,Ts; Nf,Ts (on 1,1?-biphenyl core); Tf,Ts; Nf,Ts (on 3,3?,5,5?- tetramethyl-1,1?-biphenyl core)]. Reaction of the Tf,Ts species with either MeMgBr/NiCl2(dppe) (for the 1,1?-binaphthyl) or (AlMe3)2(DABCO)/Pd2(dba)3 (for the 1,1?-biphenyl) affords 2-OH-2?-Me-1,1?-biaryl units on subsequent hydrolysis (crystallographically characterised in the binaphthyl case). The latter methyl/hydroxy compounds are doubly deprotonated by either nBuLi/TMEDA or nBuLi/tBuOK to afford dianions that react cleanly with Cl 2SiPh2 (two X-ray structures). The equivalent reaction of the 2-OH-2?-Me-1,1?-binaphthyl with Ph(O)Cl2 is less clean due to the absence of a strong Thorpe-Ingold effect. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
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