Category: chiral-catalyst. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-Hydroxypicolinic acid, is researched, Molecular C6H5NO3, CAS is 22468-26-4, about Chemical optimization of whole-cell transfer hydrogenation using carbonic anhydrase as host protein. Author is Rebelein, Johannes G.; Cotelle, Yoann; Garabedian, Brett; Ward, Thomas R..
Artificial metalloenzymes combine a synthetic metallo-cofactor with a protein scaffold and can catalyze abiotic reactions in vivo. Herein, we report on our efforts to valorize human carbonic anhydrase II as a scaffold for whole-cell transfer hydrogenation. Two platforms were tested: periplasmic compartmentalization and surface display in Escherichia coli. A chem. optimization of an IrCp* cofactor was performed. This led to 90 turnovers in the cell, affording a 69-fold increase in periplasmic product formation over the previously reported, sulfonamide-bearing IrCp* cofactor. These findings highlight the versatility of carbonic anhydrase as a promising scaffold for whole-cell catalysis with artificial metalloenzymes.
As far as I know, this compound(22468-26-4)Category: chiral-catalyst can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.