Chemistry, like all the natural sciences, Category: chiral-catalyst, begins with the direct observation of nature¡ª in this case, of matter.57-48-7, Name is (3S,4R,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one, SMILES is [H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)C(=O)CO, belongs to chiral-catalyst compound. In a document, author is Miura, Hiroki, introduce the new discover.
Efficient borylation of sp(3) C-O bonds by supported Au catalysts is described. Au nanoparticles supported on TiO2 showed high activity under mild conditions employing low catalyst loading conditions without the aid of any additives, such as phosphine and bases. A variety of allyl, propargyl, and benzyl substrates participated in the heterogeneously catalyzed reactions to furnish the corresponding allyl, allenyl, and benzyl boronates in high yields. Besides, Au/TiO2 was also effective for the direct borylation of allylic and benzylic alcohols. A mechanistic investigation based on a Hammett study and control experiments revealed that sp(3) C-O bond borylation over supported Au catalysts proceeded through S(N)1′-type mechanism involving the formation of a carbocationic intermediate. The high activity, reusability, and environmental compatibility of the supported Au catalysts as well as the scalability of the reaction system enable the practical synthesis of valuable organoboron compounds.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 57-48-7. Category: chiral-catalyst.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare