Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: 541-14-0, 541-14-0, Name is (S)-3-Hydroxy-4-(trimethylammonio)butanoate, molecular formula is C7H15NO3, belongs to chiral-catalyst compound. In a document, author is Hussain, Muhammad Ajaz, introduce the new discover.
We are exploiting the use of a versatile catalyst taken from heterogeneous catalysis, i.e., ZrOCl2.8H(2)O to efficiently catalyze the reaction of dextran-succinate conjugate (Dex-SAn) with salicylic acid (SA) under homogeneous reaction conditions. Dextran was first linked with succinic anhydride using triethylamine as a base in DMAc to provide active functionalities (succinate moieties) situated away from the polymer chains. The resultant Dex-SAn conjugate was further esterified with SA using zirconium (IV) oxychloride octahydrate (ZrOCl2.8H(2)O) as a catalyst at 80 degrees C under N-2. Reaction conditions and amount of catalyst ZrOCl2.8H(2)O and chiral support MCM-41 were optimized. This reaction methodology resulted in macromolecular prodrugs of SA as Dex-SAn-SA conjugates in good yield. The structures of Dex-SAn and newly synthesized Dex-SAn-SA conjugates were characterized using various spectroscopic techniques, i.e., FT-IR, H-1, and APT-C-13 NMR spectroscopy. The degree of substitution of SA on to Dex-SAn-SA was determined by UV/Vis spectroscopic methods. This reaction methodology can be modeled as a new protocol for facile attachment of several drug molecules onto the highly potential and biodegradable drug carrier dextran.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 541-14-0. Recommanded Product: 541-14-0.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare