Chemistry, like all the natural sciences, Quality Control of (R)-Propane-1,2-diol, begins with the direct observation of nature— in this case, of matter.4254-14-2, Name is (R)-Propane-1,2-diol, SMILES is C[C@@H](O)CO, belongs to chiral-catalyst compound. In a document, author is Wang, Si-Qing, introduce the new discover.
A vinylogous aldol-type reaction of allylazaarenes and aldehydes is disclosed that affords a series of chiral gamma-hydroxyl-alpha,beta-unsaturated azaarenes in moderate to excellent yields with high to excellent regio- and enantioselectivities. With (R,R-P)-TANIAPHOS and (R,R)-QUINOXP* as the ligand, the carbon-carbon double bond in the products is generated in (E)-form. With (R)-DTBM-SEGPHOS as the ligand, (Z)-form carbon-carbon double bond is formed in the major product. In this vinylogous reaction, aromatic, alpha,beta-unsaturated, and aliphatic aldehydes are competent substrates. Moreover, a variety of azaarenes, such as pyrimidine, pyridine, pyrazine, quinoline, quinoxaline, quinazoline, and benzo[d]imidazole are well-tolerated. At last, the chiral vinylogous product is demonstrated as a suitable Michael acceptor towards CuI-catalyzed nucleophilic addition with organomagnesium reagents.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 4254-14-2. Quality Control of (R)-Propane-1,2-diol.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare