4488-22-6, [1,1′-Binaphthalene]-2,2′-diamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of BINAM (148 mg, 0. 5 mmol) in THF (anhydrous, 10 mL) was added dropwise 2.5 M n-BuLi in cyclohexane (0.56 mL, 1.4 mmol) at -40oC over 40 min and the reaction mixture was stirred for 1 h. The chlorodiphenylphosphine (440 mg, 1.8 mmol) was added and the reaction was stirred for a further 10 h at -40oC to room temperature. Then, the reaction was quenched with saturated sodium bicarbonate and the mixture was dissolved in little water and extracted with EtOAc (15 mL ¡Á 3). The combined organic extracts were dried (MgSO4)and concentrated. The residue was purified by column chromatography on silica gel using PE-EtOAc as the eluent, to give A-3; yield: 255 mg (67%);, 4488-22-6
The synthetic route of 4488-22-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Zhang, Yu; Mao, Mao; Ji, Yi-Gang; Zhu, Jie; Wu, Lei; Tetrahedron Letters; vol. 57; 3; (2016); p. 329 – 332;,
Chiral Catalysts
Chiral catalysts – SlideShare