602-09-5, [1,1′-Binaphthalene]-2,2′-diol is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
NaH (1.92 g, 80 mmol) was added to DMF (30 mL) in an ice bath. BINOL (1,1?-bi-2-naphthol) (10 g , 34 mmol) in THF (50 ml) was dropped to this solution for 20 min. After 30 min, chloromethyl methyl ether (6.4 g, 80 mmol) was dropped to this solution for 20 min. The reaction was monitored by TLC. After 1 h stirring, 3 was isolated from the organic layer by extraction of the reaction mixture with chloroform and water. The product 3 was further purified by silica gel column chromatography with a petroleum ether/ethyl acetate (5/1)mixture. Yield: 90%.1H NMR (400 MHz, CDCl3) delta 7.95-7.93 (d, J = 9.6Hz, 2H), 7.87-7.85 (d, J = 8.4 Hz, 2H), 7.58-7.56 (d, J = 9.6 Hz, 2H),7.35-7.31 (m, 2H), 7.23-7.14 (m, 4H), 5.08-4.96 (q, J = 6.8 Hz, 4H), 3.13 (s,6H)., 602-09-5
602-09-5 [1,1′-Binaphthalene]-2,2′-diol 762831, achiral-catalyst compound, is more and more widely used in various fields.
Reference£º
Article; Zhang, Kewei; Wu, Shengying; Qu, Dahui; Wang, Limin; Tetrahedron Letters; vol. 57; 10; (2016); p. 1133 – 1137;,
Chiral Catalysts
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