In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase, published in 2011, which mentions a compound: 39856-52-5, mainly applied to imidazo pyridine derivative preparation structure IGF1R tyrosine kinase antitumor, Safety of N5,N5-Dimethylpyridine-2,5-diamine.
We disclose a novel series of insulin-like growth factor-1 receptor kinase inhibitors based on the 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridine scaffold. The influence on the inhibitory activity of substitution on the imidazopyridine and at the C5 position of the pyrimidine is discussed. In the course of this optimization, we discovered a potent and selective inhibitor with suitable pharmacokinetics for oral administration.
After consulting a lot of data, we found that this compound(39856-52-5)Safety of N5,N5-Dimethylpyridine-2,5-diamine can be used in many types of reactions. And in most cases, this compound has more advantages.