Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Application In Synthesis of Phytosphingosine, 554-62-1, Name is Phytosphingosine, SMILES is CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO, belongs to chiral-catalyst compound. In a document, author is Xu, Guangpeng, introduce the new discover.
Axially-unfixed 2,2 ‘-bipyridine-based chiral catalysts were synthesized using enantiopure amino acids as chiral sources, which were successfully used in asymmetric aldol reactions ofp-nitrobenzaldehyde with cyclohexanone, while the bulkier aldehyde derivatives (2-naphthaldehyde, 9-anthracenecarboxaldehyde, and 1-pyrenecarboxaldehyde) were selected to further elucidate the catalytic properties. Particularly, the influences of the bipyridine-proline chiral structures and the polarities of used solvents (petroleum ether, toluene, CH2Cl2, ethanol, DMF, DMSO, and water) on the catalytic performance were investigated. The results indicated that the structure of bipyridine catalysts, the molecular volume of aldehydes, and the polarity of solvents have significant effects on the catalytic activities, in which, the smaller steric effects were conducive to the improvement of the yields and stereoselectivities for asymmetric aldol reaction, along with the increased polarity of used solvents and the decreased molecular volume of aldehydes. Meanwhile, the chemical identity of all compounds was confirmed by(1)H-NMR,C-13-NMR, HRMS, and HPLC analysis.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 554-62-1. Application In Synthesis of Phytosphingosine.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare