A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 7512-17-6, Name is N-Acetyl-D-glucosamine, molecular formula is C8H15NO6. In an article, author is Zhu, Dong-Xing,once mentioned of 7512-17-6, Product Details of 7512-17-6.
Asymmetric insertion of an arylvinylcarbenoid into the C-H bond for direct enantioselective C(sp(2))-H functionalization of aniline derivatives catalyzed by a rhodium(I)-diene complex was developed for the first time. The reaction occurred exclusively at the uncommon vinyl terminus site with excellent E selectivity and enantioselectivities, providing various chiral gamma,gamma-gem-diarylsubstituted alpha,beta-unsaturated esters with broad functional group compatibility under simple and mild conditions. It provides a rare example of the asymmetric C-H insertion of arenes with selective vinylogous reactivity. Synthesis applications of this protocol were featured by several versatile product transformations. Systematic DFT calculations were also performed to elucidate the reaction mechanism and origin of the uncommon enantio- and regioselectivity of the Rh(I)-catalyzed C(sp(2))-H functionalization reaction. The measured and computed inverse deuterium kinetic isotope effect supports the C-C bond-formation step as the rate-determining step. Attractive interactions between the chiral ligand and substrates were also proposed to control the enantioselectivity.
Interested yet? Keep reading other articles of 7512-17-6, you can contact me at any time and look forward to more communication. Product Details of 7512-17-6.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare