In an article, author is Zhu, Wen-Run, once mentioned the application of 6645-46-1, Safety of (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride, Name is (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride, molecular formula is C7H16ClNO3, molecular weight is 197.66, MDL number is MFCD00066100, category is chiral-catalyst. Now introduce a scientific discovery about this category.
Herein, we report an enantioselective dehydrative gamma-arylation of alpha-indolyl propargylic alcohols with phenols via organocatalysis, which provides efficient access to chiral tetrasubstituted allenes and naphthopyrans in high yields with excellent regio- and enantioselectivities under mild conditions. This method features the use of cheaply available naphthols/phenols as the C-H aryl source and liberating water as the sole byproduct. Control experiments suggest that the excellent enantioselectivity and remote regioselectivity stem from dual hydrogen-bonding interaction with the chiral phosphoric acid catalyst.
If you are interested in 6645-46-1, you can contact me at any time and look forward to more communication. Safety of (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare