Category: 10466-61-2

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《CH2 rocking vibrations of polyethylene glycols》. Authors are Kuroda, Yoko; Kubo, Masaji.The article about the compound:H-Leu-NH2.HClcas:10466-61-2,SMILESS:N[C@@H](CC(C)C)C(N)=O.[H]Cl).Category: chiral-catalyst. Through the article, more information about this compound (cas:10466-61-2) is conveyed.

Measurements were made of the infrared absorptions of ethylene glycol and polyethylene glycols (from a dimer to a heptamer) in liquid state. These chain mols. take a more or less irregular form resulting from the trans and gauche min. of the internal rotation about single bonds. Ethylene glycol shows only 2 absorption peaks in the wave number range of CH2 rocking modes. A plausible explanation is presented based on the formation of intramol. H bonds.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Computed Properties of C6H15ClN2O. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Synthesis and Pharmacological Profiling of the Metabolites of Synthetic Cannabinoid Drugs APICA, STS-135, ADB-PINACA, and 5F-ADB-PINACA.

Synthetic cannabinoids (SCs) containing a 1-pentyl-1-H substituted indole or indazole are abused around the world and are associated with an array of serious side effects. These compounds undergo extensive phase 1 metabolism after ingestion with little understanding whether these metabolites are contributing to the cannabimimetic activity of the drugs. This work presents the synthesis and pharmacol. characterization of the major metabolites of two high concern SCs; APICA and ADB-PINACA. In a fluorometric assay of membrane potential, all metabolites that did not contain a carboxylic acid functionality retained potent activity at both the CB1 (EC50 = 14-787 nM) and CB2 (EC50 = 5.5-291 nM) receptors regardless of heterocyclic core or 3-carboxamide substituent. Of note were the 5-hydroxypentyl and 4-pentanone metabolites which showed significant increases in CB2 functional selectivity. These results suggest that the metabolites of SCs potentially contribute to the overall pharmacol. profile of these drugs.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Reference of H-Leu-NH2.HCl. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about New insights into the synthesis and characterization of 2-methoxy-3-alkylpyrazines and their deuterated isotopologues. Author is Schmarr, H.-G.; Sang, W.; Ganss, S.; Koschinski, S.; Meusinger, R..

A previously described synthetic route for preparation of 2-methoxy-3-alkylpyrazines (MPs) based on condensation of glyoxal with an α-amino acid amide, followed by methylation with iodomethane yields 3-alkyl-1-methyl-1H-pyrazin-2-ones (N-Me derivatives), rather than the expected 2-methoxy-3-alkylpyrazines (O-Me derivatives). Despite similar NMR and mass spectral properties, gas chromatog. retention indexes differ significantly, indicating chem. difference. With the example of 3-sec-butyl-1-methyl-1H-pyrazin-2-one and its 3-sec-butyl-1-[2H3]methyl-1H-pyrazin-2-one isotopolog, the position of the Me group introduced could be assigned unambiguously, using heteronuclear multiple bond correlation NMR experiments For future characterization, the spectroscopic (NMR, EI+MS) as well as GC retention index data on two stationary phases of the most aroma relevant MPs and their deuterated isotopologues are summarized. Copyright © 2011 John Wiley & Sons, Ltd.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Fujii, Kiyonaga; Ikai, Yoshitomo; Mayumi, Tsuyoshi; Oka, Hisao; Suzuki, Makoto; Harada, Ken-ichi published the article 《A nonempirical method using LC/MS for determination of the absolute configuration of constituent amino acids in a peptide: elucidation of limitations of Marfey’s method and of its separation mechanism》. Keywords: absolute configuration amino acid Marfey method; fluorodinitrophenylamino acid HPLC retention absolute configuration.They researched the compound: H-Leu-NH2.HCl( cas:10466-61-2 ).Synthetic Route of C6H15ClN2O. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:10466-61-2) here.

As the first step in establishing the author’s proposed method, the advanced Marfey’s method, which is planned for the simultaneous determination of the absolute configuration of amino acids in a peptide, Marfey’s method was applied to com. available amino acids, and the separation behavior was examined in detail. Although good resolution of the diastereomeric pair of an individual amino acid was obtained for all amino acids tested and the applicability of the method was confirmed, the (1-fluoro-2,4-dinitrophenyl)-5-L-alaninamide (FDAA) derivative of the L-amino acid was not always eluted prior to its corresponding D-amino acid derivative Because this proposed method relies on the elution order of a derivatized amino acid with FDAA to determine its absolute configuration, its separation mechanism was carefully investigated using UV and NMR spectral techniques. The results suggested that the resulting conformations of the L- and D-amino acid derivatives are stable and that the resolution between the L- and D-amino acid derivatives is due to the difference in their hydrophobicity, which is derived from the cis- or trans-type arrangement of two more hydrophobic substituents at both α-carbons of an amino acid and L-alanine amide, so that the FDAA derivative of the cis (Z)-type arrangement interacts more strongly with ODS silica gel and has a longer retention time than that of the trans (E)-type arrangement. Therefore, the L-amino acid derivative is usually eluted from the column before its corresponding D-amino acid derivative in Marfey’s method. According to this separation mechanism, the elution order of a desired amino acid can be elucidated from the average retention time of the L- and D-amino acid derivatives, and the DL-serine and DL-asparagine derivatives are critical for Marfey’s method.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Name: H-Leu-NH2.HCl. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Side reactions in enzymic peptide synthesis in organic media: effects of enzyme, solvent, and substrate concentrations. Author is Gololobov, Mikhail Yu.; Stepanov, Valentin M.; Voyushina, Tatjana L.; Morozova, Irina P.; Adlercreutz, Patrick.

The progress of enzymic peptide synthesis catalyzed by α-chymotrypsin and subtilisin from Bacillus subtilis strain 72 (subtilisin 72) in low water systems was studied. The initial reaction mixture consisted of the solvent, the acyl-group donor (Mal-Ala-Ala-Phe-OMe or Z-Ala-Ala-PheO-Me; Mal = maleyl, Z = benzyloxycarbonyl), the nucleophile H-Xaa-NH2 (Xaa = Phe, Leu, Ala), and the enzyme adsorbed on porous silica material. All amino acid residues were of the L-configuration. The solvent consisted of acetonitrile, DMF and 4% (volume/volume) of water. The DMF/acetonitrile ratio was varied between 0 and 1/1. At high concentration of the acyl-group donor, quant. formation of Mal-Ala-Ala-Phe-Xaa-NH2 or Z-Ala-Ala-Phe-Xaa-NH2 occurred. As a result, a method for the synthesis of peptide amides was developed. At low concentration of the acyl group donor and excess of the nucleophile, condensation byproducts with two and three nucleophile mols. were found in the reaction mixtures The data obtained provided evidence that organic solvents affected the S1′-specificity of α-chymotrypsin and the S1-specificity of subtilisin 72, while the S1-specificity of α-chymotrypsin and the S1′-specificity of subtilisin 72 were not affected. When the DMF content was increased, the rate of the α-chymotrypsin-catalyzed reactions decreased. In contrast to this, an increase in DMF content accelerated the subtilisin 72-catalyzed reactions. Hydrolysis of the acyl group donor did not occur in the α-chymotrypsin-catalyzed reactions. Significant (up to 50%) formation of Mal-Ala-Ala-Phe-OH was observed at the early stage of the subtilisin 72-catalyzed reactions. Later, Mal-Ala-Ala-Phe-OH underwent synthesis.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Synthetic Route of C6H15ClN2O. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Leucine and its derivatives as potential elicitors of insulin secretion in rats. Author is Warner, Victor D.; Warner, Ann M.; Vasselli, Joseph R.; Decke, Elisabeth; Pi-Sunyer, F. Xavier; Woods, Stephen C..

In rats, i.p. administration of L-leucine-HCl [760-84-9], DL-leucine-HCl [2508-63-6], and L-leucineamide-HCl [10466-61-2] increased serum levels of glucose [50-99-7] and immunoreactive insulin, while L-leucine esters had no significant effect.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Safety of H-Leu-NH2.HCl. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Peptide synthesis catalyzed by α-chymotrypsin immobilized in the poly(N-isopropylacrylamide/acrylamide) gel.

The peptide syntheses were performed with α-chymotrypsin immobilized in the thermosensitive poly(N-isopropylacrylamide/acrylamide) (NIPAAm/AAm) gels. In the reaction between Ac-Phe-OEt and H-Ala-NH2, the product ratio of Ac-Phe-Ala-NH2/Ac-Phe-OH increased with lowering temperature The highest ratio was 3.3 in the reaction with the immobilized enzyme at -10°, whereas it was around 1.4 with the free enzyme at 34°. On the contrary, Cbz-Phe-Leu-NH2 obtained from Cbz-Phe-OH and H-Leu-NH2 increased with increasing temperature (conversion: 13% at 10° and 34% at 35°) in Tris buffer without the organic solvent. The gel of NIPAAm copolymerized with AAm (NIPAAm/AAm = 80/20) was effective as compared with the poly(NIPAAm) gel for α-chymotrypsin-catalyzed peptide synthesis using the ester substrate as the acyl donor. The reaction mechanism was discussed in connection with the hydrophobic surroundings inside the deswollen thermosensitive polymer gel.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Efficient synthesis of phthaloyl derivatives of α-amino carboxamides, published in 2002, which mentions a compound: 10466-61-2, mainly applied to phthaloyl amino carboxamide preparation, SDS of cas: 10466-61-2.

A rapid and one-pot synthesis of phthaloyl derivatives of α-amino carboxamides is described. In dichloromethane, α-amino carboxamides react with mono-Me phthalate in the presence of BOP and i-Pr2NEt to afford the intermediate Nα-[o-(methoxycarbonyl)benzoyl]amino carboxamides which undergo cyclization in dichloromethane/water in the presence of aqueous sodium hydroxide and tetrabutylammonium bromide catalyst to afford the corresponding Nα-phthaloyl amides in excellent yields.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Chymotrypsin suspended in organic solvents with salt hydrates is a good catalyst for peptide synthesis from mainly undissolved reactants.Recommanded Product: H-Leu-NH2.HCl.

Chymotrypsin powder suspended in organic solvents in the presence of Na2CO3.10H2O catalyzes peptides synthesis from R-Ala-Phe-OMe (R = Me3CO2C, PhCH2O2C) and H-Leu-NH2. The reaction proceeds best in the most nonpolar solvents, such as hexane, despite the fact that both reactants and products remainly largely undissolved. H-Leu-NH2.HCl can be used in place of the free base.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: H-Leu-NH2.HCl(SMILESS: N[C@@H](CC(C)C)C(N)=O.[H]Cl,cas:10466-61-2) is researched.Category: isoxazole. The article 《Kinetics of enzymatic solid-to-solid peptide synthesis: synthesis of Z-aspartame and control of acid-base conditions by using inorganic salts》 in relation to this compound, is published in Biotechnology and Bioengineering. Let’s take a look at the latest research on this compound (cas:10466-61-2).

Enzymic peptide synthesis can be carried out efficiently in solid-to-solid reaction mixtures with 10% (weight/weight) water added to a mixture of substrates. The final reaction mass contains ≥80% (by weight) of product. This article deals with acid-base effects in such reaction mixtures and the consequences for the enzyme. In the Thermoase-catalyzed synthesis of Z-Asp-Phe-OMe, the reaction rate is strongly dependent on the amount of basic salts added to the system. The rate increases 20 times, as the KHCO3 or K2CO3 added is raised 2.25-fold from an amount equimolar to the Phe-OMe · HCL starting material. With further increases in KHCO3 addition, the initial rate remains at the maximum, but with K2CO3 it drops sharply. Addition of NaHCO3 is less effective, but rates are faster if more water is used. With >1.5 equiv of basic salt, the final yield of the reaction decreases. Similar effects are observed when thermolysin catalyzes the same reaction, or Z-Gln-Leu-NH2 synthesis. These effects can be rationalized using a model estimating the pH of these systems, taking into account the possible formation of up to ten different solid phases.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare