Category: 10466-61-2

SDS of cas: 10466-61-2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Influence of pseudoallylic strain on the conformational preference of 4-methyl-4-phenylpipecolic acid derivatives. Author is Sugg, Elizabeth E.; Griffin, Jane F.; Portoghese, Philip S..

The preparation of the title compounds [cis- and trans-I; R = OH, NHCH(CONH2)CH2CHMe2; R1 = CO2CMe3, H] was described. Double-resonance proton spectroscopy revealed that the conformational preference of substituents attached to the ring depends on the hybridization of the piperidine N. In the free amino acids or leucinamide dipeptides, the C-2 carboxyl group is equatorial. Introduction of a carbamyl moiety on the piperidine N induces a change in the ring conformation such that the C-2 carboxyl group is axial, despite a cis-diaxial interaction with the C-4 substituent. The inverted conformational preference of the C-2 and C-4 groups in the tert-butoxycarbonyl and unprotected derivatives is attributed to a severe steric interaction between the partially sp2 hybridized NCO moiety in the carbamate group and an equatorial C-2 carboxyl group. The x-ray crystal structures of both cis- and trans-I (R = OH, R1 = CO2CMe3) corroborate the solution spectroscopic studies and the concept of pseudoallylic strains in substituted piperidine carbamates. In addition, comparison of the two crystallog. determined structures indicates that H bonding to the carbonyl of the carbamate produces delocalization into the N-C bond, resulting in a shorter bond and more planar piperidyl N. The conformational preference afforded by pseudoallylic strain indicates that substituted pipecolic acids can be used in the design of conformationally restricted peptide analogs.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: H-Leu-NH2.HCl(SMILESS: N[C@@H](CC(C)C)C(N)=O.[H]Cl,cas:10466-61-2) is researched.COA of Formula: C9H16O2. The article 《Ultrasound and ZnCl2 promoted synthesis of phthaloyl derivatives of α-amino carboxamides》 in relation to this compound, is published in Synthesis. Let’s take a look at the latest research on this compound (cas:10466-61-2).

A new, one-step and racemization-free synthesis of phthaloyl derivatives of α-amino carboxamides is described. Under ultrasound, α-amino carboxamides and dipeptide derivatives react with monomethyl phthalate in the presence of BOP, ZnCl2 and i-Pr2NEt to afford the corresponding Nu-phthaloyl α-amino carboxamides or dipeptides in good to excellent yields. Cyclization of the intermediate Nu-[(o-methoxycarbonyl)benzoyl]amino carboxamides to the desired products was very slow when the reaction was conducted either in the absence of ZnCl2 and/or without sonication, but the process was greatly accelerated when both ZnCl2 and ultrasound were used.

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Electric Literature of C6H15ClN2O. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Fatty acids’ double role in the prebiotic formation of a hydrophobic dipeptide. Author is Murillo-Sanchez, Sara; Beaufils, Damien; Gonzalez Manas, Juan Manuel; Pascal, Robert; Ruiz-Mirazo, Kepa.

In search of a connection between prebiotic peptide chem. and lipid compartments, the reaction of a 5(4H)-oxazolone with leucinamide was extensively explored under buffered aqueous conditions, where diverse amphiphiles and surfactants could form supramol. assemblies. Significant increases in yield and changes in stereoselectivity were observed when fatty acids exceeded their critical aggregation concentration, self-assembling into vesicles in particular. This effect does not take place below the fatty acid solubility limit, or when other anionic amphiphiles/surfactants are used. Data from fluorimetric and Langmuir trough assays, complementary to the main HPLC results reported here, demonstrate that the dipeptide product co-localizes with fatty acid bilayers and monolayers. Addnl. experiments in organic solvents suggest that acid-base catalysis operates at the water-aggregate interface, linked to the continuous proton exchange dynamics that fatty acids undergo at pH values around their effective pKa. These simple amphiphiles could therefore play a dual role as enhancers of peptide chem. under prebiotic conditions, providing soft and hydrophobic organic domains through self-assembly and actively inducing catalysis at their interface with the aqueous environment. Our results support a systems chem. approach to life’s origin.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: H-Leu-NH2.HCl(SMILESS: N[C@@H](CC(C)C)C(N)=O.[H]Cl,cas:10466-61-2) is researched.Recommanded Product: 3235-67-4. The article 《Thermolysin- and chymotrypsin-catalyzed peptide synthesis in the presence of salt hydrates》 in relation to this compound, is published in Progress in Biotechnology. Let’s take a look at the latest research on this compound (cas:10466-61-2).

Thermolysin (EC 3.4.24.4) suspended in hexane in the presence of Na2SO4.10H2O catalyzes the synthesis of N-protected dipeptide and tripeptide amides in good yields. The influence of different mixing conditions, including sonication, was investigated.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Klabunovskii, E. I.; Sokolova, N. P.; Neupokoev, V. I.; Antonova, T. A.; Ternovskii, S. E. researched the compound: H-Leu-NH2.HCl( cas:10466-61-2 ).Name: H-Leu-NH2.HCl.They published the article 《Asymmetric ruthenium catalyst modified by optically active amino acids》 about this compound( cas:10466-61-2 ) in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya. Keywords: asym hydrogenation acetoacetate; ruthenium amino acid hydrogenation. We’ll tell you more about this compound (cas:10466-61-2).

Asym. hydrogenation of Et acetoacetate was accomplished with Ru or 5% Ru/SiO2 catalysts modified by treatment with optically active amino acids. The highest optical yield was obtained with L-glutamic acid. The variations of the optical yield with the pH and temperature of the solutions in which the catalysts were modified were plotted. The optimal pH was close to the isoelec. point of the amino acid.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about The Mo(η-allyl)(CO)2 Moiety as a Robust Marker Group in Bioorganometallic Chemistry. Unusual Crystal Structure of the Phenylalanine Derivative Mo(C5H4-CO-Phe-OMe)(η-allyl)(CO)2.Electric Literature of C6H15ClN2O.

The MoCp(η-C3H5)(CO)2 (Cp = η-cyclopentadienyl) moiety is introduced as a new labeling group in bioorganometallic chem. The acid Mo(C5H4-CO2H)(η-C3H5)(CO)2 (2) was obtained from the reaction of MoCp(η-C3H5)(CO)2 (1) with BuLi and solid CO2 followed by aqueous workup. Coupling of 2 to amino acids with various complexity and C-terminal functionality by standard peptide chem. methods yielded the amino acid derivatives Mo(C5H4-CO-AA-R)(η-C3H5)(CO)2, 3 (3a, AA = Phe, R = OCH3; 3b, AA = Leu, R = NH2; 3c, AA = Gly, R = OCH3). In addition, the dipeptide derivative Mo(C5H4-CO-Leu-Phe-OCH3)(η-C3H5)(CO)2 (4) was synthesized by reacting 2 with H-Leu-Phe-OCH3. All new compounds are characterized by elemental anal., IR, MS, and NMR spectroscopy. X-ray anal. on 3a shows the unit cell to contain two independent mols., A and B, which differ mainly by the orientation of the allyl and carbonyl groups with respect to the amino acid substituent on the Cp ring. Furthermore, an allyl-endo conformation for both A and B is observed This is the first example of such a conformation in the crystal structure of a MoCp(C3H5)(CO)2 derivative In solution, both the exo and endo isomer are present, as concluded from 1H NMR spectroscopy approx. in a 4:1 ratio. The activation barriers of interconversion were determined to be 62.7 ± 0.5 kJ mol-1 (3a) and 60.5 ± 0.5 kJ mol-1 (3c).

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Fredholt, K.; Adrian, C.; Just, L.; Hoj Larsen, D.; Weng, S.; Moss, B.; Juel Friis, G. researched the compound: H-Leu-NH2.HCl( cas:10466-61-2 ).Product Details of 10466-61-2.They published the article 《Chemical and enzymic stability as well as transport properties of a Leu-enkephalin analog and ester prodrugs》 about this compound( cas:10466-61-2 ) in Journal of Controlled Release. Keywords: Leu enkephalin ester prodrug. We’ll tell you more about this compound (cas:10466-61-2).

The Leu-enkephalin analog (Tyr-d-Ala-Gly-Phe-Leu-NH2) was synthesized together with three esters prodrugs. The prodrugs synthesized were the O-acetyl, O-propionyl and O-pivaloyl esters of the tyrosine phenol group. The compounds were isolated with good purity (HPLC purity >99%) and in good yields (60-75%). The chem. and enzymic stability of the prodrugs has been investigated in detail. The prodrugs studied are quite chem. stable and the degradation of the prodrugs follows the pattern previously shown for similar esters (U-shaped pH-profile; maximal stability at pH 4-5). The prodrugs are degraded quant. in plasma to the parent peptide with half-lives in the range 2.9 min-2.6 h. Type B esterases were shown to be involved in the degradation as the half-lives increased in the presence of paraoxon. No significant stabilization was seen in 10% porcine gut homogenate. Half-lives in the same order were seen for the analog and the prodrugs in pure Leucine aminopeptidase solution The analog was stable in Carboxypeptidase A solution whereas a faster degradation of the prodrugs was seen in this media. Furthermore the transport properties of the compounds has been studied. A Papp value of 0.284×10-6 cm/s for the analog was obtained for the transport across Caco-2 cell monolayers in the BL-AP direction. The Papp values were increased by a factor of 2, 7 and 18 for the acetyl-, propionyl- and pivaloyl prodrug. The increase could be explained by higher lipophilicities of the prodrugs compared to the analog.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about N-tert-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer, the main research direction is small cell lung cancer prenylation indole ring cytotoxicity antagonist.COA of Formula: C6H15ClN2O.

Natural prenylated indoles have been proposed as potential anticancer agents. To exploit this discovery for developing new peptide therapeutics, we report the first studies whereby incorporation of prenylated indoles into primary sequences has been achieved. We developed a route to synthesize Nα-Fmoc-protected tryptophan derivatives in which the prenyl group is linked to the N-indole core, using Pd(II)-mediated C-H functionalization of 2-methyl-2-butene. Based on the Substance P antagonist G (SPG), a well-known Small Cell Lung Cancer (SCLC) anticancer agent, we designed a new penta-peptide sequence to include a prenyl moiety on one of the tryptophan residues. The N-tert-prenylated tryptophan analog was assembled into the pentameric peptide using standard solid phase peptide synthesis or liquid phase synthesis by fragment coupling. In vitro screening showed that the N-tert-prenylation of the indole ring on the tryptophan residue located near the C-terminal of the penta-peptide enhanced the cytotoxicity against H69 (IC50 = 2.84 ± 0.14 μM) and DMS79 (IC50 = 4.37 ± 0.44 μM) SCLC cell lines when compared with the unmodified penta-peptide (H69, IC50 = 30.74 ± 0.30 μM and DMS79, IC50 = 23.00 ± 2.07 μM) or the parent SPG sequence (IC50 > 30 μM, both cell lines). SCLC almost invariably relapses with therapy-resistant disease. The DMS79 cell line was established from a patient following treatment with a number of chemotherapeutics (cytoxan, vincristine and methotrexate) and radiation therapy. Treating DMS79 tumor-bearing nude mice provided a human xenograft model of drug resistance to test the efficacy of the prenylated peptide. A low dose (1.5 mg kg-1) of the prenylated peptide was found to reduce tumor growth by ∼30% (P < 0.05) at day 7, relative to the control group receiving vehicle only. We conclude that the availability of the Fmoc-Trp(N-tert-prenyl)-OH amino acid facilitates the synthesis of prenylated-tryptophan-containing peptides to explore their therapeutic potential. Here is a brief introduction to this compound(10466-61-2)COA of Formula: C6H15ClN2O, if you want to know about other compounds related to this compound(10466-61-2), you can read my other articles.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Synthesis of polypeptides by microwave heating I. Formation of polypeptides during repeated hydration-dehydration cycles and their characterization, the main research direction is polymerization amino acid amide microwave.Application In Synthesis of H-Leu-NH2.HCl.

Amino acid amides effectively reacted to produce polypeptides in response to microwave heating during repeated hydration-dehydration cycles. The polypeptides, formed from a mixture of glycinamide, alaninamide, valinamide, and aspartic acid α-amide, had mol. weights ranging from 1000 to 4000 daltons. Amino acids were incorporated into the polypeptides in proportion to the starting concentrations, with the exception of glycine, whose incorporation was 1.5 times higher than that of the other amino acids. The polypeptides had some definite secondary structure, such as α-helix and β-sheet, in aqueous solution This reaction provides not only a convenient method for abiotic peptide formation but also a convenient method for the chem. synthesis of peptides.

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