Category: 137848-28-3

As a common heterocyclic compound, it belongs to chiral-catalyst compound, name is (R)-2′-amino-[1,1′-binaphthalen]-2-ol, and cas is 137848-28-3, its synthesis route is as follows.,137848-28-3

General procedure: Modified method [67]. 3-tert-Butylsalicylaldehyde (1.78 g,10.0 mmol) was mixed with (R)-2-amino-2′-hydroxy-1,1′-binaphthyl (2.85 g, 10.0 mmol) in dry toluene (50 mL). A few 4 A molecular sieves were added, and the solution was warmed up to 70 Cand kept for two days at this temperature. The solution was filtered and the solvent was removed under reduced pressure. The residue was purified by column chromatography (n-hexane/ethyl acetate= 5:1) to give 2H2 as a yellow solid. Yield: 4.09 g (92%). M.p.: 86-88 C. 1H NMR (C6D6): d 13.28 (s, 1H, OH), 8.31 (s, 1H, CHN), 7.80 (m, 4H, aryl), 7.62 (d, J = 8.4 Hz, 1H, aryl), 7.38 (d, J = 8.9 Hz,1H, aryl), 7.22 (m, 5H, aryl), 7.12 (m, 2H, aryl), 6.87 (d, J = 7.5 Hz,1H, aryl), 6.71 (t, J = 7.6 Hz, 1H, aryl), 4.52 (br s, 1H, OH), 1.45 (s,9H, CH3). These spectroscopic data were in agreement with those reported in the literature [67].

With the complex challenges of chemical substances, we look forward to future research findings about 137848-28-3,belong chiral-catalyst compound

Reference£º
Article; Chen, Liang; Zhao, Ning; Wang, Qiuwen; Hou, Guohua; Song, Haibin; Zi, Guofu; Inorganica Chimica Acta; vol. 402; (2013); p. 140 – 155;,
Chiral Catalysts
Chiral catalysts – SlideShare

(R)-2′-amino-[1,1′-binaphthalen]-2-ol, cas is 137848-28-3, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,137848-28-3

General procedure: Modified method [69]. Salicylaldehyde (1.22 g, 10.0 mmol) was mixed with (R)-2-amino-2′-hydroxy-1,1′-binaphthyl (2.85 g,10.0 mmol) in dry toluene (50 mL). A few 4 A molecular sieves were added, and the solution was warmed up to 70 C and kept for two days at this temperature. The solution was filtered, and the filtrate was concentrated to 10 mL. Yellow microcrystals 1H2 were isolated when this solution was kept at -20 C for two days. Yield: 3.31 g (85%). M.p.: 120-122 C. 1H NMR (C6D6): d 12.45 (s, 1H, OH), 8.23 (s, 1H, CHN), 7.83 (m, 2H, aryl), 7.74 (m, 2H,aryl), 7.57 (d, J = 8.4 Hz, 1H, aryl), 7.36 (m, 1H, aryl), 7.28 (m, 2H, aryl), 7.17 (m, 2H, aryl), 7.11 (m, 2H, aryl), 6.96-6.83 (m,3H, aryl), 6.62 (t, J = 7.2 Hz, 1H, aryl), 4.73 (s, 1H OH). These spectroscopicdata were in agreement with those reported in the literature [69].

With the rapid development of chemical substances, we look forward to future research findings about (R)-2′-amino-[1,1′-binaphthalen]-2-ol

Reference£º
Article; Chen, Liang; Zhao, Ning; Wang, Qiuwen; Hou, Guohua; Song, Haibin; Zi, Guofu; Inorganica Chimica Acta; vol. 402; (2013); p. 140 – 155;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO40,mainly used in chemical industry, its synthesis route is as follows.,137848-28-3

General procedure: This compound was prepared as a yellow solid from the reaction of pyridine-2-carboxaldehyde (1.07 g, 10.0 mmol) with (R)-2-amino-2′-hydroxy-1,1′-binaphthyl (2.85 g, 10.0 mmol) indry toluene (50 mL) in the presence of 4 A molecular sieves at 70 C and recrystallization from a toluene solution by a similar procedure as in the synthesis of 1H2. Yield: 2.99 g (80%). M.p.: 180-182 C. 1H NMR (C6D6): d 8.62 (s, 1H, CHN), 7.88 (s, 1H, aryl), 7.61 (m, 2H, aryl), 7.52 (m, 5H, aryl), 7.24 (d, J = 8.0 Hz, 1H, aryl), 7.10-6.95 (m, 5H, aryl), 6.56 (t, J = 6.8 Hz, 1H, aryl), 6.24 (m, 1H,aryl); the proton of the OH group was not observed. These spectroscopic data were in agreement with those reported in the literature [69].

With the synthetic route has been constantly updated, we look forward to future research findings about (R)-2′-amino-[1,1′-binaphthalen]-2-ol,belong chiral-catalyst compound

Reference£º
Article; Chen, Liang; Zhao, Ning; Wang, Qiuwen; Hou, Guohua; Song, Haibin; Zi, Guofu; Inorganica Chimica Acta; vol. 402; (2013); p. 140 – 155;,
Chiral Catalysts
Chiral catalysts – SlideShare

137848-28-3, (R)-2′-amino-[1,1′-binaphthalen]-2-ol is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of 3,4-dimethoxy-3-cyclobutene-1 ,2-dione (Ia) (0.2 mmol) in MeOH (0.25- 1 mL) the amine 2a-m was firstly added at room temperature. After the correspondingreaction time (ti) (see Table I), the amine 4a-n (0.2 mmol) was then added with MeOH (1.75-1 mL). After the corresponding reaction time (t2) (see Table I and Table Ibis), the product was purified by filtration or by column chromatography. Yields are reported in Table I and Table Ibis and pure compounds were obtained as stable solids.

137848-28-3, As the paragraph descriping shows that 137848-28-3 is playing an increasingly important role.

Reference£º
Patent; UNIVERSIDAD DE ZARAGOZA; CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC); MARQUEZ LOPEZ, Maria Eugenia; ALEGRE REQUENA, Juan Vicente; PEREZ HERRERA, Raquel; (70 pag.)WO2016/5407; (2016); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

137848-28-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. (R)-2′-amino-[1,1′-binaphthalen]-2-ol, cas is 137848-28-3,the chiral-catalyst compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Modified method [69]. Salicylaldehyde (1.22 g, 10.0 mmol) was mixed with (R)-2-amino-2′-hydroxy-1,1′-binaphthyl (2.85 g,10.0 mmol) in dry toluene (50 mL). A few 4 A molecular sieves were added, and the solution was warmed up to 70 C and kept for two days at this temperature. The solution was filtered, and the filtrate was concentrated to 10 mL. Yellow microcrystals 1H2 were isolated when this solution was kept at -20 C for two days. Yield: 3.31 g (85%). M.p.: 120-122 C. 1H NMR (C6D6): d 12.45 (s, 1H, OH), 8.23 (s, 1H, CHN), 7.83 (m, 2H, aryl), 7.74 (m, 2H,aryl), 7.57 (d, J = 8.4 Hz, 1H, aryl), 7.36 (m, 1H, aryl), 7.28 (m, 2H, aryl), 7.17 (m, 2H, aryl), 7.11 (m, 2H, aryl), 6.96-6.83 (m,3H, aryl), 6.62 (t, J = 7.2 Hz, 1H, aryl), 4.73 (s, 1H OH). These spectroscopicdata were in agreement with those reported in the literature [69].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of (R)-2′-amino-[1,1′-binaphthalen]-2-ol, 137848-28-3

Reference£º
Article; Chen, Liang; Zhao, Ning; Wang, Qiuwen; Hou, Guohua; Song, Haibin; Zi, Guofu; Inorganica Chimica Acta; vol. 402; (2013); p. 140 – 155;,
Chiral Catalysts
Chiral catalysts – SlideShare

137848-28-3, (R)-2′-amino-[1,1′-binaphthalen]-2-ol is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Modified method [69]. Salicylaldehyde (1.22 g, 10.0 mmol) was mixed with (R)-2-amino-2′-hydroxy-1,1′-binaphthyl (2.85 g,10.0 mmol) in dry toluene (50 mL). A few 4 A molecular sieves were added, and the solution was warmed up to 70 C and kept for two days at this temperature. The solution was filtered, and the filtrate was concentrated to 10 mL. Yellow microcrystals 1H2 were isolated when this solution was kept at -20 C for two days. Yield: 3.31 g (85%). M.p.: 120-122 C. 1H NMR (C6D6): d 12.45 (s, 1H, OH), 8.23 (s, 1H, CHN), 7.83 (m, 2H, aryl), 7.74 (m, 2H,aryl), 7.57 (d, J = 8.4 Hz, 1H, aryl), 7.36 (m, 1H, aryl), 7.28 (m, 2H, aryl), 7.17 (m, 2H, aryl), 7.11 (m, 2H, aryl), 6.96-6.83 (m,3H, aryl), 6.62 (t, J = 7.2 Hz, 1H, aryl), 4.73 (s, 1H OH). These spectroscopicdata were in agreement with those reported in the literature [69]., 137848-28-3

As the paragraph descriping shows that 137848-28-3 is playing an increasingly important role.

Reference£º
Article; Chen, Liang; Zhao, Ning; Wang, Qiuwen; Hou, Guohua; Song, Haibin; Zi, Guofu; Inorganica Chimica Acta; vol. 402; (2013); p. 140 – 155;,
Chiral Catalysts
Chiral catalysts – SlideShare

(R)-2′-amino-[1,1′-binaphthalen]-2-ol, cas is 137848-28-3, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,137848-28-3

To a magnetically stirred solution of R-(+)-2-amino-1,1′-binaphthalen-2-ol (0.215g, 0.753mmol) in DMAC (15mL) was slowly added a solution of trans- 1 (0.116 g, 0.378 mmol) in DMAC (10 mL). After the addition was complete, the reaction mixture was stirred in the dark at room temperature for 24 h and then poured into water (300 mL), giving an orange precipitate. The solid was collected by filtration and was then dissolved in CHCl3 (250 mL) and washed with water (3¡Á100 mL) and brine (50 mL). The organic phase was dried over anhydrous sodium sulfate and then concentrated in vacuo to furnish monomer trans-2RR (87% yield) as a bright orange powder. M.p.: >250C (decomposition). 1H NMR (DMSO-d6, 500MHz) delta 9.87 (s, 2H), 9.10 (s, 2H), 8.24-8.28 (m, 2H), 8.13-8.18 (m, 2H), 8.07-8.10 (m, 2H), 8.00-8.05 (m, 2H), 7.93-7.96 (m, 2H), 7.81-7.86 (m, 4H), 7.52-7.59 (m, 6H), 7.46-7.50 (m, 2H), 7.34-7.40 (m, 2H), 7.29-7.33 (m, 2H), 7.20-7.26 (m, 4H), 6.97-7.03 (m, 2H); MS m/e: 805.28 ([M]H+); [alpha]D=(+)207 (c=0.076g/dL, THF).

As the rapid development of chemical substances, we look forward to future research findings about 137848-28-3

Reference£º
Article; Lynch, Joseph G.; Jaycox, Gary D.; Polymer; vol. 55; 16; (2014); p. 3564 – 3572;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.137848-28-3,(R)-2′-amino-[1,1′-binaphthalen]-2-ol,as a common compound, the synthetic route is as follows.

To a magnetically stirred solution of R-(+)-2-amino-1,1′-binaphthalen-2-ol (0.206 g, 0.722 mmol) in DMAC (15 mL) was slowly added a solution of terephthaloyl chloride (0.0733 g, 0.361 mmol) in DMAC (10mL). After the addition was complete, the reaction mixture was stirred at room temperature for 24h and then concentrated in vacuo to give a crude tan solid. The solid was dissolved in CHCl3 (300 mL) and washed with water (3¡Á100 mL) and brine (50 mL). The organic phase was dried over anhydrous sodium sulfate and then concentrated in vacuo to furnish monomer 3RR (85% yield) as a light tan powder. mp: >250C (decomposition). 1H NMR (DMSO-d6, 500MHz) delta 9.74 (s, 2H), 8.83 (s, 2H), 8.15-8.18 (m, 2H), 8.03-8.07 (m, 2H), 7.97-8.02 (m, 4H), 7.91-7.95 (m, 2H), 7.43-7.48 (m, 2H), 7.37-7.41 (m, 2H), 7.24-7.33 (m, 4H), 7.09-7.17 (m, 8H), 6.86-6.90 (m, 2H); MS m/e: 701.24 ([M]H+). [alpha]D=(+)76 (c=0.130g/dL, THF)., 137848-28-3

As the paragraph descriping shows that 137848-28-3 is playing an increasingly important role.

Reference£º
Article; Lynch, Joseph G.; Jaycox, Gary D.; Polymer; vol. 55; 16; (2014); p. 3564 – 3572;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.137848-28-3,(R)-2′-amino-[1,1′-binaphthalen]-2-ol,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 3,4-dimethoxy-3-cyclobutene-1 ,2-dione (Ia) (0.2 mmol) in MeOH (0.25- 1 mL) the amine 2a-m was firstly added at room temperature. After the correspondingreaction time (ti) (see Table I), the amine 4a-n (0.2 mmol) was then added with MeOH (1.75-1 mL). After the corresponding reaction time (t2) (see Table I and Table Ibis), the product was purified by filtration or by column chromatography. Yields are reported in Table I and Table Ibis and pure compounds were obtained as stable solids., 137848-28-3

The synthetic route of 137848-28-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSIDAD DE ZARAGOZA; CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC); MARQUEZ LOPEZ, Maria Eugenia; ALEGRE REQUENA, Juan Vicente; PEREZ HERRERA, Raquel; (70 pag.)WO2016/5407; (2016); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

(R)-2′-amino-[1,1′-binaphthalen]-2-ol, cas is 137848-28-3, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,137848-28-3

General procedure: To a mixture of 3,4-dimethoxy-3-cyclobutene-1 ,2-dione (Ia) (0.2 mmol) in MeOH (0.25- 1 mL) the amine 2a-m was firstly added at room temperature. After the correspondingreaction time (ti) (see Table I), the amine 4a-n (0.2 mmol) was then added with MeOH (1.75-1 mL). After the corresponding reaction time (t2) (see Table I and Table Ibis), the product was purified by filtration or by column chromatography. Yields are reported in Table I and Table Ibis and pure compounds were obtained as stable solids.

As the rapid development of chemical substances, we look forward to future research findings about 137848-28-3

Reference£º
Patent; UNIVERSIDAD DE ZARAGOZA; CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC); MARQUEZ LOPEZ, Maria Eugenia; ALEGRE REQUENA, Juan Vicente; PEREZ HERRERA, Raquel; (70 pag.)WO2016/5407; (2016); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare