Category: 137848-28-3

(R)-2′-amino-[1,1′-binaphthalen]-2-ol, cas is 137848-28-3, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,137848-28-3

General procedure: To a mixture of 3,4-dimethoxy-3-cyclobutene-1 ,2-dione (Ia) (0.2 mmol) in MeOH (0.25- 1 mL) the amine 2a-m was firstly added at room temperature. After the correspondingreaction time (ti) (see Table I), the amine 4a-n (0.2 mmol) was then added with MeOH (1.75-1 mL). After the corresponding reaction time (t2) (see Table I and Table Ibis), the product was purified by filtration or by column chromatography. Yields are reported in Table I and Table Ibis and pure compounds were obtained as stable solids.

With the rapid development of chemical substances, we look forward to future research findings about 137848-28-3

Reference£º
Patent; UNIVERSIDAD DE ZARAGOZA; CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC); MARQUEZ LOPEZ, Maria Eugenia; ALEGRE REQUENA, Juan Vicente; PEREZ HERRERA, Raquel; (70 pag.)WO2016/5407; (2016); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

(R)-2′-amino-[1,1′-binaphthalen]-2-ol, cas is 137848-28-3, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,137848-28-3

To a magnetically stirred solution of R-(+)-2-amino-1,1′-binaphthalen-2-ol (0.206 g, 0.722 mmol) in DMAC (15 mL) was slowly added a solution of terephthaloyl chloride (0.0733 g, 0.361 mmol) in DMAC (10mL). After the addition was complete, the reaction mixture was stirred at room temperature for 24h and then concentrated in vacuo to give a crude tan solid. The solid was dissolved in CHCl3 (300 mL) and washed with water (3¡Á100 mL) and brine (50 mL). The organic phase was dried over anhydrous sodium sulfate and then concentrated in vacuo to furnish monomer 3RR (85% yield) as a light tan powder. mp: >250C (decomposition). 1H NMR (DMSO-d6, 500MHz) delta 9.74 (s, 2H), 8.83 (s, 2H), 8.15-8.18 (m, 2H), 8.03-8.07 (m, 2H), 7.97-8.02 (m, 4H), 7.91-7.95 (m, 2H), 7.43-7.48 (m, 2H), 7.37-7.41 (m, 2H), 7.24-7.33 (m, 4H), 7.09-7.17 (m, 8H), 6.86-6.90 (m, 2H); MS m/e: 701.24 ([M]H+). [alpha]D=(+)76 (c=0.130g/dL, THF).

With the rapid development of chemical substances, we look forward to future research findings about 137848-28-3

Reference£º
Article; Lynch, Joseph G.; Jaycox, Gary D.; Polymer; vol. 55; 16; (2014); p. 3564 – 3572;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.137848-28-3,(R)-2′-amino-[1,1′-binaphthalen]-2-ol,as a common compound, the synthetic route is as follows.

General procedure: Modified method [67]. 3-tert-Butylsalicylaldehyde (1.78 g,10.0 mmol) was mixed with (R)-2-amino-2′-hydroxy-1,1′-binaphthyl (2.85 g, 10.0 mmol) in dry toluene (50 mL). A few 4 A molecular sieves were added, and the solution was warmed up to 70 Cand kept for two days at this temperature. The solution was filtered and the solvent was removed under reduced pressure. The residue was purified by column chromatography (n-hexane/ethyl acetate= 5:1) to give 2H2 as a yellow solid. Yield: 4.09 g (92%). M.p.: 86-88 C. 1H NMR (C6D6): d 13.28 (s, 1H, OH), 8.31 (s, 1H, CHN), 7.80 (m, 4H, aryl), 7.62 (d, J = 8.4 Hz, 1H, aryl), 7.38 (d, J = 8.9 Hz,1H, aryl), 7.22 (m, 5H, aryl), 7.12 (m, 2H, aryl), 6.87 (d, J = 7.5 Hz,1H, aryl), 6.71 (t, J = 7.6 Hz, 1H, aryl), 4.52 (br s, 1H, OH), 1.45 (s,9H, CH3). These spectroscopic data were in agreement with those reported in the literature [67].

The synthetic route of 137848-28-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Liang; Zhao, Ning; Wang, Qiuwen; Hou, Guohua; Song, Haibin; Zi, Guofu; Inorganica Chimica Acta; vol. 402; (2013); p. 140 – 155;,
Chiral Catalysts
Chiral catalysts – SlideShare

137848-28-3, (R)-2′-amino-[1,1′-binaphthalen]-2-ol is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: This compound was prepared as a yellow solid from the reaction of pyridine-2-carboxaldehyde (1.07 g, 10.0 mmol) with (R)-2-amino-2′-hydroxy-1,1′-binaphthyl (2.85 g, 10.0 mmol) indry toluene (50 mL) in the presence of 4 A molecular sieves at 70 C and recrystallization from a toluene solution by a similar procedure as in the synthesis of 1H2. Yield: 2.99 g (80%). M.p.: 180-182 C. 1H NMR (C6D6): d 8.62 (s, 1H, CHN), 7.88 (s, 1H, aryl), 7.61 (m, 2H, aryl), 7.52 (m, 5H, aryl), 7.24 (d, J = 8.0 Hz, 1H, aryl), 7.10-6.95 (m, 5H, aryl), 6.56 (t, J = 6.8 Hz, 1H, aryl), 6.24 (m, 1H,aryl); the proton of the OH group was not observed. These spectroscopic data were in agreement with those reported in the literature [69].

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Reference£º
Article; Chen, Liang; Zhao, Ning; Wang, Qiuwen; Hou, Guohua; Song, Haibin; Zi, Guofu; Inorganica Chimica Acta; vol. 402; (2013); p. 140 – 155;,
Chiral Catalysts
Chiral catalysts – SlideShare