Category: 141556-45-8

141556-45-8, 1,3-Dimesityl-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of pyrazine ligand 1 or 2 (1mmol), Li2PdCl4 (1mmol) and NaOAc (1mmol) in 20mL of dry methanol was stirred for 24hat rt. The yellow solids (yield: 92%) were collected by filtration and washed several times with methanol, which can be assigned to be palladacyclic dimers. Then, a Schlenk tube was charged with the above chloride-bridged palladacyclic dimers (0.5mmol), the corresponding imidazolium salt (1.25mmol) and tBuOK (2.5mmol) under nitrogen. Dry THF was added by a cannula and stirred at room temperature for 3h. The product was separated by passing through a short silica gel column with CH2Cl2 as eluent, the third band was collected and afforded the corresponding carbene adducts 3-10 as yellow solids. The characterization data for 3: Yield: 78%., 141556-45-8

141556-45-8 1,3-Dimesityl-1H-imidazol-3-ium chloride 2734211, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Xu, Chen; Wang, Zhi-Qiang; Fu, Wei-Jun; Ji, Bao-Ming; Yuan, Xiao-Er; Han, Xin; Xiao, Zhi-Qiang; Hao, Xin-Qi; Song, Mao-Ping; Journal of Organometallic Chemistry; vol. 777; (2015); p. 1 – 5;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141556-45-8,1,3-Dimesityl-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

To anhydrous 1,4-dioxane (20 mL), [Pd(acac)2] (1 g, 3.3 mmol,1 equiv) and IMes*HCl (1.43 g, 3.7 mmol, 1.1 equiv) were added. The mixture was refluxed for 24 h. After the reaction, solvent was evaporated under vacuum. Diethyl ether was then added and stirred until no more solid was dissolved. The solution was filtered and diethyl ether was removed under vacuum. Yellow powder was washed with n-pentane and dried under vacuum. Yellow solids, yield:85%, 1H NMR (399.78 MHz, CDCl3) delta 7.08-6.94 (br,6H), 5.1 (s, 1H), 2.47-2.02 (br, 18H), 1.84-1.73 (6H), 13CNMR (100.53 MHz, CDCl3) delta 187.21, 183.16, 153.93,139.29, 137.60, 136.35, 135.01, 129.76, 128.90, 123.8,122.57, 99.68, 27.17, 25.61, 21.29, 18.93, 17.85.Synthesis of (IMes)Pd(tmhd)Cl. Yellow solids, yield:76%, 1H NMR (399.78 MHz, CDCl3) delta 7.09-6.96 (6H),5.50 (s, 1H), 2.40-2.31 (12H), 2.21-2.16 (6H), 1.04-0.95(18H), 13C NMR (100.53 MHz, CDCl3) delta 139.08, 136.64,135.40, 130.00, 128.74, 124.04, 90.65, 41.15-40.64, 29.07,28.51, 21.25, 18.99.

The synthetic route of 141556-45-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lee, Dong Jin; Kim, Myungwoong; Kim, Chan Kyung; Lee, Ik Mo; Bulletin of the Korean Chemical Society; vol. 40; 7; (2019); p. 710 – 718;,
Chiral Catalysts
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141556-45-8, 1,3-Dimesityl-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Palladium (II) complex with 1-methylimidazole ligands[PdCl2(1-methylimidazole)2] (0.5 mmol, 0.17 g), K2CO3 (1.5 mmol,0.21 g), MgSO4 (0.2 g, for drying), an appropriate imidazoliumchloride (0.65 mmol) and finally a mixture of solvents CH3CN:THF(8 ml: 5 ml) were placed in a round-bottom flask equipped with astirring bar. The flask was capped with a rubber septum. Themixture was heated in the oil bath for 24 h at 50 C in the air atmosphere.During that time, the color changed from yellow togreenish. After the reaction, the cooled down mixture was filtratedto remove inorganic salts. Then, the yellow solutionwas evaporatedunder vacuum and the resulting oily residue was dissolved in aminimum amount of acetone. Next, 10 ml of water was slowlyadded to the yellow solution and clouding of the mixture wasobserved. The mixture was left to evaporate acetone and to enablesedimentation of the formed precipitate. After that time, waterwith excess of the imidazolium chloride and 1-methylimidazolewas decanted. The obtained product was washed with the waterand dried under vacuum. The complexes 2f and 2 g were obtainedfrom the appropriate imidazole and the precipitated solids requiredadditional washing with ethyl alcohol and diethyl ether. One of theobtained complexes [PdCl2(IMes)(1-methylimidazole)] (2e) wasdescribed in the literature [7b].

141556-45-8 1,3-Dimesityl-1H-imidazol-3-ium chloride 2734211, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Sikorski; Zawartka; Trzeciak; Journal of Organometallic Chemistry; vol. 867; (2018); p. 323 – 332;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141556-45-8,1,3-Dimesityl-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

Prepared according a procedure of Mohr et al.21 To a soln of1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride (175 mg,0.513 mmol) in CH2Cl2 (10 mL) was added HgO (108 mg,0.514 mmol) and Me4NCl (56.4 mg, 0.51 mmol). After stirring at r.t. for 15 h, the soln was passed through Celite, the solvent was removed in vacuo, and the residue was washed with H2O (2 ¡Á 10 mL) and Et2O (2 ¡Á 10 mL) to give 14 as a colorless solid; yield: 240 mg (82%); mp 270 C (dec); Rf = 0.09 (CH2Cl2-MeOH, 10:1).

141556-45-8 1,3-Dimesityl-1H-imidazol-3-ium chloride 2734211, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Emsermann, Jens; Arduengo, Anthonyj.; Opatz, Till; Synthesis; vol. 45; 16; (2013); p. 2251 – 2264;,
Chiral Catalysts
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141556-45-8, 1,3-Dimesityl-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a Schlenk flask under argon, to a THF suspension (20 mL) of 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride (1 g, 2.93 mmol), solid potassium tert-butoxide (0.35 g, 3.12 mmol) was added in a single portion. The mixture was stirred for 45 min at room temperature, and volatiles were removed under vacuum. After addition of THF (20 mL) and stirring for 5 min, the reaction mixture was filtered under argon, and carbon tetrabromide (2.42 g, 5.86 mmol) in THF (10 mL) was added dropwise to solution, over a period of ca. 30 min. The resulting brown solution was stirred for 4 h. Subsequent removal of volatiles in vacuo gave a dark brown residue that was extracted into toluene (10 mL) and then a solution of HCl in dioxane (4 mol/L) was added, and the resulting white precipitate was collected. Yield 351 mg (29%). 1H NMR (500 MHz, DMSO-d6): delta 2.13 (s, 12H, o-CH3), 2.39 (s, 6H, p-CH3), 7.27 (s, 4H, Ar-H), 10.13 (s, 1H, HNCN); 1H NMR (500 MHz, CDCl3): delta 2.20 (s, 6H, p-CH3), 2.54 (s, 12H, o-CH3), 6.82 (s, 4H, Ar-H), 10.16 (s, 1H, HNCN); 13C NMR (125 MHz, DMSO-d6): delta 16.9, 20.7, 113.1, 129.3, 129.6, 135.1, 140.5, 141.7; Elemental analysis calcd. for C21H23Br2ClN2: C 50.58, H 4.65, N 5.62; found C 50.55, H 4.59, N 5.67; ESI-MS (C21H23Br2Cl1N2) (m/z): 497.4 [M]+.

141556-45-8 1,3-Dimesityl-1H-imidazol-3-ium chloride 2734211, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Amini, Mojtaba; Bagherzadeh, Mojtaba; Rostamnia, Sadegh; Chinese Chemical Letters; vol. 24; 5; (2013); p. 433 – 436;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141556-45-8,1,3-Dimesityl-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

SIMes-HCI (100 mg, 0.292 mmol), [Pd(cin)(M-CI)]2 (62.9 mg, 0.122 mmol), a magnetic stir bar and acetone (1.2 mL) were charged into a vial or round bottom flask , followed by K2C03 (33.5 mg, 0.243 mmol). The mixture was stirred at 60 C for 5 h. The general work up procedure was then followed, affording the product as microcrystalline material in 80% (135 mg) yield. XH NMR (400 MHz, CDCh): delta (ppm) =67.12 (m, 3H), 7.06 (m, 2H), 6.96 (d, J = 11.19 Hz, 4H), 5.30 (s, 1 H), 5.12-5.04 (m, 1H), 4.27 (d, J = 12.96 Hz, 1H), 3.99 (m, 4H), 3.27 (d, J = 6.86 Hz, 1H), 2.44 (d, J = 15.24 Hz, 10H), 2.31 (s, 6H), 1.93 (m, 1H). 13C {XH} IMMR (100 MHz, CDCb): delta (ppm) = delta 210.9 (C, carbene), 138.0 (C), 137.8 (C), 136.3 (C), 135.7 (C), 129.1 (CH), 128.0 (CH), 127.5 (CH), 127.1 (CH), 126.4 (CH), 109.4 (CH), 92.1 (CH), 51.0 (CH2), 46.5 (CH2), 20.9 (CHs).Elemental analysis: Expected : C 66.76, H 7.72, N 4.21. Found : C 66.63, H 7.64, N 4.27.

As the paragraph descriping shows that 141556-45-8 is playing an increasingly important role.

Reference£º
Patent; UMICORE AG & CO. KG; NOLAN, Steven P.; (47 pag.)WO2018/115029; (2018); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141556-45-8,1,3-Dimesityl-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

General procedure: [HIPr]2[PdCl4]: 0.45 g (1.0 mmol) of [HIPr]Cl was added to thesolution of 0.14 g (0.48 mmol) PdCl2(cod) in hot CH3CN (5 mL). Themixture was heated for 15 min, until the yellow solution becamered. The solution was cooled to room temperature and solventwas removed under reduced pressure. The product was precip-itated by addition of diethyl ether (2-3 mL). Product yield: 85%;elemental analysis calcd. (%) for PdCl4C54H78N4: C 62.88, H 7.62,N 5.46; found: C 62.37, H 7.46, N 5.40.1H NMR(500 MHz, CD3CN,25C, TMS): = 8.49 (s, 2H, N CH N); 7.57 (t, J(H,H) = 7.8 Hz, 4H,Ar); 7.42 (d, J(H,H) = 7.8 Hz, 8H, Ar); 4.48 (s, 8H, CH2CH2); 3.10(m, J(H,H) = 6.9 Hz, 8H, CH); 1.40 (d, J(H,H) = 6.9 Hz, 24H, CH3); 1.26(d, J(H,H) = 6.9 Hz, 24H, CH3,);13C NMR (125.75 MHz, CD3CN, 25C,TMS): = 160.0 (N CH N); 147.2 (Ar); 131.0 (Ar); 125.5 (Ar); 53.7(CH2CH2); 28.5 (CH); 24.0 (CH3); 23.5 (CH3).

As the paragraph descriping shows that 141556-45-8 is playing an increasingly important role.

Reference£º
Article; Silarska; Trzeciak; Pernak; Skrzypczak; Applied Catalysis A: General; vol. 466; (2013); p. 216 – 223;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141556-45-8,1,3-Dimesityl-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

General procedure: General Method: To a 20 mL solution of 1.1 equivalents of nickelocene (41 mg, 0.22 mmol) in anhydrous THF, the respective imidazolium NHC precursor (0.2 mmol) was added as a solid. The resulting suspension was then refluxed for 4 h. The general method was modified for 4, 5 and 6. The reactions involving the formation of more electron-deficient 4 and 5 required 10 h at reflux with 2 equivalents of nickelocene (75 mg, 0.4 mmol). Synthesis of 6 was achieved after 16 h of reflux in the presence of 2.6 equivalents of nickelocene (98 mg, 0.52 mmol). The compounds were then purified by column chromatography. Details available in the Supporting information.

141556-45-8 1,3-Dimesityl-1H-imidazol-3-ium chloride 2734211, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Conference Paper; Luca, Oana R.; Thompson, Bennett A.; Takase, Michael K.; Crabtree, Robert H.; Journal of Organometallic Chemistry; vol. 730; (2013); p. 79 – 83;,
Chiral Catalysts
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141556-45-8, 1,3-Dimesityl-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

8. Chemical reaction involving potassium metal in phosphonium-based ionic liquids: generation of an NHC in a PIL; [00063] l,3-6/s(2,4,6-trimethylphenyl) imidazolium chloride (2.00 g, 5.87mmol) and an excess of potassium metal (0.35 g, 8.75 mmol), previously washedwith anhydrous THF, were added to trihexyl(tetradecyl) phosphonium chloride (10 mL). The reaction mixture was heated at 80 C under nitrogen for 24 hours. Hexanes (10 ml) were added to the resulting suspension and the solution was filtered through Celite to remove undissolved materials. Evacuation to remove hexanes gave a brown viscous residue that was characterized as a solution of trihexyl(tetradecyl) phosphonium chloride and l,3-ft/s(2,4,6-trimethylphenyl)-imidazol-2-ylidene.; 10. Formation of ./V-heterocvclic carbenes in phosphonium-based ionic liquids; [00065] l,3-&w(2,4,6-trimethylphenyl)imidazolium chloride (0.25 g, 100% 13Clabeled at C2) and a solution composed of ether free PhMgBr (2.00 mmol) dissolved in trihexyl(tetradecyl) phosphonium decanoate (5 mL) were mixed at room temperature. A small amount of toluene was added to reduce the viscosity and to facilitate stirring. NMR studies on the reaction mixtures show the presence of a major peak in the 13C NMR spectrum at 218 ppm, consistent with the formation of l,3-Z>/.s(2,4,6-trimethylphenyl) imidazol-2-ylidene.[00066] l,3-*w(2,4,6-trimethylphenyl) imidazolium chloride (2.00 g, 5.87mmol) and an excess of potassium metal (0.35 g, 8.75 mmol), previously washed with anhydrous THF, were added to trihexyl(tetradecyl) phosphonium chloride (15 mL). The reaction mixture was heated at 80 C under nitrogen for 24 hours. Hexanes (10 mL) were added to the resulting suspension and the solution was filtered through Celite. Evacuation to remove hexanes gave a reddish brown viscous material, and this residue was characterized as a solution of trihexyl(tetradecyl) phosphonium chloride and l,3-izs(2,4,6-trimethylphenyl)imidazol-2-ylidene.

As the paragraph descriping shows that 141556-45-8 is playing an increasingly important role.

Reference£º
Patent; SIMON FRASER UNIVERSITY; WO2006/7703; (2006); A1;,
Chiral Catalysts
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141556-45-8, 1,3-Dimesityl-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

taken the imidazole chlorine salt [(R 1 NCHCHNR 1) CH]Cl (0.34 g, 1.0 mmol), ferrous bromide (0.22 g, 1.0 mmol) and sodium bromide (0.33 g, 3.2 mmol), in thf as the solvent, the 60 C reaction under 16 hours. Centrifugal, supernatant fluid transfer, remove precipitation, is added to the supernatant liquid of the three ring hexyl phosphine (0.28 g, 1.0 mmol), in 30 C reaction under 6 hours. Vacuum to remove the solvent, hexane washing, drying, in a mixed solvent of toluene and tetrahydrofuran extraction, centrifugal supernatant fluid transfer, after concentrating the serum to obtain a target product, yield 84%.

The synthetic route of 141556-45-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Suzhou University; sun, hongmei; li, zhuang; liu, ling; chen, qi; (17 pag.)CN105541922; (2016); A;,
Chiral Catalysts
Chiral catalysts – SlideShare