Category: 173035-10-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.173035-10-4,1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

Synthesis of [(SIMes)CuCl]. This synthesis is as reported in the literature; see S. Diez-Gonzalez et al., J. Org. Chem. 2005, 70, 4784-4796. In a 250 mL Schlenk flask were added copper(I) chloride (1.0 g, 10.10 mmol), 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydro-imidazol-2-ylidenium chloride (SIMes-HCl, 10.10 mmol), and sodium tert-butoxide (0.97 g, 10.10 mmol). To this flask, dry tetrahydrofuran (100 mL) was added under an inert atmosphere of argon, and the mixture was magnetically stirred for 20 hours at room temperature. After the mixture was filtered through a plug of Celite and then evaporating the solvent under vacuum, a white solid was obtained. 1H NMR (400 MHz, CDCl3) delta=6.96 (s, 4H), 3.96 (s, 4H), 2.32 (s, 12H), 2.30 (s, 6H); 13C NMR (100 MHz, CDCl3) delta=202.8, 138.7, 135.3, 135.0, 129.7, 50.9, 21.0, 18.0. Elemental analysis calcd for C21H26CuClN2: C, 62.21; H, 6.46; N, 6.91. Found: C, 62.60; H, 6.52; N, 6.80%., 173035-10-4

As the paragraph descriping shows that 173035-10-4 is playing an increasingly important role.

Reference£º
Patent; Institut Catala d’Investigacio Quimica; Institucio Catalana de Recerca i Estudis Avancats; US2009/69569; (2009); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.173035-10-4,1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

Add ligand L3343mg (1.0mmol), copper powder 192mg (3.0mmol), 20 mL of water in a 50mL flask, 70 ~ 80 oil bath, the reaction was stirred for 20 hours, the reaction mixture was cooled to room temperature, filtered, the filter cake was washed 3 times with water, the filter cake dissolved in acetonitrile and filtered to remove unreacted copper powder, the solvent was evaporated under reduced pressure to give 199mg as colorless crystals, a yield of 49%

173035-10-4, As the paragraph descriping shows that 173035-10-4 is playing an increasingly important role.

Reference£º
Patent; China Petroleum & Chemical Corporation Shanghai Research Institute of Petrochemical.; Liu, Bo; Jin, Zhaosheng; Lu, Jiangang; Li, Xianming; Zhou, Haichun; (13 pag.)CN105585584; (2016); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to chiral-catalyst compound, name is 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride, and cas is 173035-10-4, its synthesis route is as follows.

General procedure: [HIPr]2[PdCl4]: 0.45 g (1.0 mmol) of [HIPr]Cl was added to thesolution of 0.14 g (0.48 mmol) PdCl2(cod) in hot CH3CN (5 mL). Themixture was heated for 15 min, until the yellow solution becamered. The solution was cooled to room temperature and solventwas removed under reduced pressure. The product was precip-itated by addition of diethyl ether (2-3 mL). Product yield: 85%;elemental analysis calcd. (%) for PdCl4C54H78N4: C 62.88, H 7.62,N 5.46; found: C 62.37, H 7.46, N 5.40.1H NMR(500 MHz, CD3CN,25C, TMS): = 8.49 (s, 2H, N CH N); 7.57 (t, J(H,H) = 7.8 Hz, 4H,Ar); 7.42 (d, J(H,H) = 7.8 Hz, 8H, Ar); 4.48 (s, 8H, CH2CH2); 3.10(m, J(H,H) = 6.9 Hz, 8H, CH); 1.40 (d, J(H,H) = 6.9 Hz, 24H, CH3); 1.26(d, J(H,H) = 6.9 Hz, 24H, CH3,);13C NMR (125.75 MHz, CD3CN, 25C,TMS): = 160.0 (N CH N); 147.2 (Ar); 131.0 (Ar); 125.5 (Ar); 53.7(CH2CH2); 28.5 (CH); 24.0 (CH3); 23.5 (CH3).

173035-10-4, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,173035-10-4 ,1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Silarska; Trzeciak; Pernak; Skrzypczak; Applied Catalysis A: General; vol. 466; (2013); p. 216 – 223;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.173035-10-4,1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

[Ru(COD)Cl2]n (300 mg, 1 mmol), IMesH2Cl (1.47 g, 4 mmol), tricyclohexylphosphine (300 mg, 1 mmol), and KN(SiMe3)2 (540 mg, 2.5 mmol) were weighed directly into a 600 mL Schlenk tube. The flask was evacuated and filled with dry argon (2¡Á). Degassed benzene (300 mL) was added and the flask was pressurized to 30 psi with H2. The suspension was vigorously stirred for 12 hours at 90 C., yielding a bright yellow solution and white precipitate (1). After cooling the reaction to 5 C., propargyl chloride (0.3 mL, 4 mmol) was slowly added via syringe and the reaction mixture was allowed to warm to room temperature. The resulting brown benzene solution was washed with degassed 1M HCl (2¡Á), degassed brine (2¡Á), filtered through Celite and concentrated in vacuo to afford compound (2) as a brown solid in 90% yield (95% purity). The brown solid displayed catalytic behavior identical with previously synthesized second-generation catalysts. Analytically pure (2) was obtained by column chromatography on silica gel (degassed 3:1 hexanes/Et2O). 1H NMR (CD2Cl2): delta 18.49 (d, J=11.1 Hz, 1H), 7.26 (d, J=10.9 Hz, 1H), 6.97 (s, 2H), 6.77 (s, 2H), 3.92 (m, 4H), 2.58 (s, 6H), 2.37 (s, 6H), 2.29 (s, 3H), 2.23 (s, 3H), 0.88-1.584 (m, 33H), 1.06 (s, 3H), 1.08 (s, 3H). 31P NMR (CD2Cl2): delta 28.9. The reaction was repeated several times with one or more reaction conditions modified so as to optimize the yield of the product. It was found that the yield could be increased to greater than 95% by reducing the reaction temperature from 90 C. to 80 C., 173035-10-4

The synthetic route of 173035-10-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CALIFORNIA INSTITUTE OF TECHNOLOGY; Grubbs, Robert H.; Chatterjee, Arnab K.; Choi, Tae-Lim; Goldberg, Steven D.; Love, Jennifer A.; Morgan, John P.; Sanders, Daniel P.; Scholl, Matthias; Toste, F. Dean; Trnka, Tina M.; (27 pag.)US9403854; (2016); B2;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.173035-10-4,1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

General procedure: [HIPr]2[PdCl4]: 0.45 g (1.0 mmol) of [HIPr]Cl was added to thesolution of 0.14 g (0.48 mmol) PdCl2(cod) in hot CH3CN (5 mL). Themixture was heated for 15 min, until the yellow solution becamered. The solution was cooled to room temperature and solventwas removed under reduced pressure. The product was precip-itated by addition of diethyl ether (2-3 mL). Product yield: 85%;elemental analysis calcd. (%) for PdCl4C54H78N4: C 62.88, H 7.62,N 5.46; found: C 62.37, H 7.46, N 5.40.1H NMR(500 MHz, CD3CN,25C, TMS): = 8.49 (s, 2H, N CH N); 7.57 (t, J(H,H) = 7.8 Hz, 4H,Ar); 7.42 (d, J(H,H) = 7.8 Hz, 8H, Ar); 4.48 (s, 8H, CH2CH2); 3.10(m, J(H,H) = 6.9 Hz, 8H, CH); 1.40 (d, J(H,H) = 6.9 Hz, 24H, CH3); 1.26(d, J(H,H) = 6.9 Hz, 24H, CH3,);13C NMR (125.75 MHz, CD3CN, 25C,TMS): = 160.0 (N CH N); 147.2 (Ar); 131.0 (Ar); 125.5 (Ar); 53.7(CH2CH2); 28.5 (CH); 24.0 (CH3); 23.5 (CH3).

173035-10-4, The synthetic route of 173035-10-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Silarska; Trzeciak; Pernak; Skrzypczak; Applied Catalysis A: General; vol. 466; (2013); p. 216 – 223;,
Chiral Catalysts
Chiral catalysts – SlideShare

1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride, cas is 173035-10-4, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,173035-10-4

General procedure: An oven-dried Schlenk flask was charged with NHC salt 1 (2.49mmol) and evacuated for 30 min. The flask was then transferredinto a nitrogen-filled glove box and isolated KH (2.49 mmol)was added. The flask was then attached to a Schlenk line(argon/vacuum), evacuated once, and filled with argon. AnhydrousTHF (30 mL) was added, and the slow evolution of hydrogenwas observed. The resulting solution was then allowed tostir for 20 h at r.t. after which time the reaction mixture was filteredthrough a dry filter stick into an oven-dried Schlenk flask.The THF was evaporated, and the resulting free carbene wasextracted into anhydrous toluene (30 mL). The resulting toluenesolution was filtered through another dry filter stick into a previouslyevacuated and oven-dried Schlenk flask containing[(cod)Ir(py)2]PF6 (2, 1.66 mmol). The reaction was allowed tostir for 2 d at r.t. under an argon atmosphere. After this time, themixture was filtered to yield the desired iridium complex 3.

As the rapid development of chemical substances, we look forward to future research findings about 173035-10-4

Reference£º
Article; Cross, Paul W. C.; Herbert, John M.; Kerr, William J.; McNeill, Alan H.; Paterson, Laura C.; Synlett; vol. 27; 1; (2016); p. 111 – 115;,
Chiral Catalysts
Chiral catalysts – SlideShare

173035-10-4, 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: An oven-dried Schlenk flask was charged with NHC salt 1 (2.49mmol) and evacuated for 30 min. The flask was then transferredinto a nitrogen-filled glove box and isolated KH (2.49 mmol)was added. The flask was then attached to a Schlenk line(argon/vacuum), evacuated once, and filled with argon. AnhydrousTHF (30 mL) was added, and the slow evolution of hydrogenwas observed. The resulting solution was then allowed tostir for 20 h at r.t. after which time the reaction mixture was filteredthrough a dry filter stick into an oven-dried Schlenk flask.The THF was evaporated, and the resulting free carbene wasextracted into anhydrous toluene (30 mL). The resulting toluenesolution was filtered through another dry filter stick into a previouslyevacuated and oven-dried Schlenk flask containing[(cod)Ir(py)2]PF6 (2, 1.66 mmol). The reaction was allowed tostir for 2 d at r.t. under an argon atmosphere. After this time, themixture was filtered to yield the desired iridium complex 3., 173035-10-4

As the paragraph descriping shows that 173035-10-4 is playing an increasingly important role.

Reference£º
Article; Cross, Paul W. C.; Herbert, John M.; Kerr, William J.; McNeill, Alan H.; Paterson, Laura C.; Synlett; vol. 27; 1; (2016); p. 111 – 115;,
Chiral Catalysts
Chiral catalysts – SlideShare

1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride, cas is 173035-10-4, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,173035-10-4

Synthesis of [(SIMes)CuCl]. This synthesis is as reported in the literature; see S. Diez-Gonzalez et al., J. Org. Chem. 2005, 70, 4784-4796. In a 250 mL Schlenk flask were added copper(I) chloride (1.0 g, 10.10 mmol), 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydro-imidazol-2-ylidenium chloride (SIMes-HCl, 10.10 mmol), and sodium tert-butoxide (0.97 g, 10.10 mmol). To this flask, dry tetrahydrofuran (100 mL) was added under an inert atmosphere of argon, and the mixture was magnetically stirred for 20 hours at room temperature. After the mixture was filtered through a plug of Celite and then evaporating the solvent under vacuum, a white solid was obtained. 1H NMR (400 MHz, CDCl3) delta=6.96 (s, 4H), 3.96 (s, 4H), 2.32 (s, 12H), 2.30 (s, 6H); 13C NMR (100 MHz, CDCl3) delta=202.8, 138.7, 135.3, 135.0, 129.7, 50.9, 21.0, 18.0. Elemental analysis calcd for C21H26CuClN2: C, 62.21; H, 6.46; N, 6.91. Found: C, 62.60; H, 6.52; N, 6.80%.

As the rapid development of chemical substances, we look forward to future research findings about 173035-10-4

Reference£º
Patent; Institut Catala d’Investigacio Quimica; Institucio Catalana de Recerca i Estudis Avancats; US2009/69569; (2009); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

173035-10-4, 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

RuCl2(?CHPh)(PCy3)s (phenylmethylene-bis(tricyclohexylphosphine) ruthenium dichloride, ?catalyst (I)?) (6.00 g, 7.29 mmol, 1.0 eq.), IMesH2.HCl salt prepared above (2 eq.), and potassium t-butoxide (2 eq.) were placed in a Schlenk flask. 60 mL of anhydrous degassed hexanes (Aldrich SureSeal bottle) were added. A vacuum was applied to further degas the reaction mixture, which was then heated to 60 C. for 24 hours. The suspension changed color from purple to orange-brown over the reaction time. After approximately 24 hr, the mixture was cooled to room temperature, and an excess of 1:1 isopropanol:water (180 mL) was added. The mixture was stirred rapidly in air for 30 min., then filtered using a medium porosity frit, and washed with isopropanol-water (3¡Á100 mL) and hexanes (3¡Á100 mL). The solids were dried in in vacuo, and the yield was approximately 75%. 1H NMR (CD2Cl2, 400 MHz) delta 19.16 (s, 1H), 7.37-7.05 (m, 9H), 3.88 (s, 4H), 2.56-0.15 (m, 51H); 31P NMR (CD2Cl2, 161.9 MHz) delta 31.41; HRMS (FAB) C45H65Cl2N2PRu [M+] 848.3306, found 848.3286., 173035-10-4

173035-10-4 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride 2734917, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Patent; CALIFORNIA INSTITUTE OF TECHNOLOGY; Grubbs, Robert H.; Chatterjee, Arnab K.; Choi, Tae-Lim; Goldberg, Steven D.; Love, Jennifer A.; Morgan, John P.; Sanders, Daniel P.; Scholl, Matthias; Toste, F. Dean; Trnka, Tina M.; (27 pag.)US9403854; (2016); B2;,
Chiral Catalysts
Chiral catalysts – SlideShare