Category: 22468-26-4

SDS of cas: 22468-26-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-Hydroxypicolinic acid, is researched, Molecular C6H5NO3, CAS is 22468-26-4, about Discovery of potent c-MET inhibitors with new scaffold having different quinazoline, pyridine and tetrahydro-pyridothienopyrimidine headgroups.

Cellular mesenchymal-epithelial transition factor (c-MET) is closely linked to human malignancies, which makes it an important target for treatment of cancer. In this study, a series of 3-methoxy-N-phenylbenzamide derivatives, N-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl) benzamide derivatives and N1-(3-fluoro-4-methoxyphenyl)-N3-(4-fluorophenyl) malonamide derivatives were designed and synthesized, some of them were identified as c-MET inhibitors. Among these compounds with new scaffolds having different quinazoline, pyridine and tetrahydro-pyridothienopyrimidine head groups, compound 11c, 11i, 13b, 13h exhibited both potent inhibitory activities against c-MET and high anticancer activity against tested cancer cell lines in vitro. In addition, kinase selectivity assay further demonstrated that both 13b and 13h are potent and selective c-MET inhibitors. Mol. docking supported that they bound well to c-MET and VEGFR2, which demonstrates that they are potential c-MET RTK inhibitors for cancer therapy.

Here is a brief introduction to this compound(22468-26-4)SDS of cas: 22468-26-4, if you want to know about other compounds related to this compound(22468-26-4), you can read my other articles.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

HPLC of Formula: 22468-26-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-Hydroxypicolinic acid, is researched, Molecular C6H5NO3, CAS is 22468-26-4, about Microbial degradation of dipicolinic acid by a laboratory isolated strain of Bacillus brevis. Author is Singh, Ravindra Pal.

A B. brevis isolated from soil utilizes dipicolinic acid (I) as a sole C and N source. O2 uptake by the vegetative cells was equivalent to I utilized. L-Ascorbate, however, inhibited both O2 uptake and I utilization. Amino acids served individually as C and N sources, but glycine or glyoxalate not only failed to support growth but inhibited metabolism when added with normal substrates. I catabolites were identified as 4-hydroxy-I and a keto acid. Apparently, the 1st step in I utilization is hydroxylation at position C-4 of the I ring, giving rise to C3 and C4 fragments upon ring cleavage. A possible pathway for I degradation by this organism is proposed.

There is still a lot of research devoted to this compound(SMILES：O=C(O)C1=NC=CC(O)=C1)HPLC of Formula: 22468-26-4, and with the development of science, more effects of this compound(22468-26-4) can be discovered.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Name: 4-Hydroxypicolinic acid. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-Hydroxypicolinic acid, is researched, Molecular C6H5NO3, CAS is 22468-26-4, about Discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by the use of docking models. Author is Ikegashira, Kazutaka; Ikenogami, Taku; Yamasaki, Takayuki; Hase, Yasunori; Yamaguchi, Takayuki; Inagaki, Koji; Doi, Satoki; Adachi, Tsuyoshi; Koga, Yoshihisa; Hashimoto, Hiromasa.

We report the discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by using a structure-based drug design (SBDD) based on a docking model. The work leads to the representative compound 4a with high CSF-1R inhibitory activity (IC50 = 9.1 nM). The obtained crystal structure of an azetidine compound with CSF-1R, which matched our predicted docking model, demonstrates that the azetidine compounds bind to the DFG-out conformation of the protein as a Type II inhibitor.

If you want to learn more about this compound(4-Hydroxypicolinic acid)Name: 4-Hydroxypicolinic acid, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(22468-26-4).

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The thermal decomposition of dialkyl chelidamates and related esters》. Authors are Markees, D. G..The article about the compound:4-Hydroxypicolinic acidcas:22468-26-4,SMILESS:O=C(O)C1=NC=CC(O)=C1).Product Details of 22468-26-4. Through the article, more information about this compound (cas:22468-26-4) is conveyed.

Di-Me 4-hydroxydipicolinate (I) heated to 200-10° lost CO2 and was converted into a mixture of di-Me 4-methoxypyridine-2,6-dicarboxylate (Ia) and N-methyl-4-pyridone (Ib). Decomposition of di-Et 4-hydroxydipicolinate (Ic) proceeded similarly but in addition to di-Et 4- ethoxypyridine-2,6-dicarboxylate and N-ethyl-4-pyridone (II) there was also isolated some Et 4-ethoxypicolinate (III). Pyrolysis of Et 4-hydroxypicolinate (IV) gave mostly II and some 4-ethoxypyridine. IV.HCl decomposed to EtCl and 4-hydroxypicolinic acid (V). III was synthesized from V by esterification and replacement of the OH by Cl and then an EtO group. N-Alkyl-4-pyridones were converted into derivatives for identification.

Here is a brief introduction to this compound(22468-26-4)Product Details of 22468-26-4, if you want to know about other compounds related to this compound(22468-26-4), you can read my other articles.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare