Some tips on 250285-32-6

As the paragraph descriping shows that 250285-32-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.250285-32-6,1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,as a common compound, the synthetic route is as follows.

In a 25 mL-volume Schlenk’s tube were placed 298 mg (0.10 mmol) of 1,3-bis(2,6-diisopropylphenyl)imidazolium chloride, 67.6 mg (0.70 mmol) of sodium t-butoxide, and 73.4 mg (0.74 mmol) of copper(I) chloride. The inner atmosphere was purged with Ar gas three times. To the content of the tube was added 5 mL of anhydrous tetra-hydrofuran (solvent) by means of a micro-syringe. The resulting mixture was stirred for 4 hours at room temperature. After the reaction was complete, the reaction mixture was filtered by celite to remove insolubles. The resulting solution was then concentrated. The concentrated product was brought into contact with a mixture of methylene chloride and diethyl ether, to precipitate 246 mg (0.50 mmol., yield 71%) of [1,3-Bis(2,6-diisopropyl-phenyl)imidazolium]copper(I) chloride as a white solid product. 1H-NMR (CD2Cl2, 300 MHz): 1.23 (d, 12H), 1.28 (d, 12H), 2.52-2.62 (m, 4H), 7.18 (s, 2H), 7.34 (d, 4H), 7.53 (dd, 2H) Elementary analysis: Found(%): C 66.44, H 7.28, N 5.77, Calculated(%) for C27H36ClCuN2: C 66.51, H 7.44, N 5.75, 250285-32-6

As the paragraph descriping shows that 250285-32-6 is playing an increasingly important role.

Reference£º
Patent; Ube Industries, Ltd.; US2005/90683; (2005); A1;,
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Downstream synthetic route of 250285-32-6

The synthetic route of 250285-32-6 has been constantly updated, and we look forward to future research findings.

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Finely powdered (CH3CN)2PdCl2 (259 mg, 1.00 mmol) was suspended in CH3CN (5 mL) and 3,5- dimetoxy-lambdayV-dimethylbenzylamine (205 mg, 1.05 mmol) was added. The solution was heated to 800C for 5 rnin and finely powdered K2CO3 (691 mg, 5.00 mmol) was added. The stirring was continued until palladacycle formation was complete, as indicated by the formation of a canary yellow solution (5-10 min). IPr-HCl (467 mg, 1.10 mmol) was added and the mixture stirred at 8O0C over 18h. The reaction mixture was filtered and evaporated. The resulting product was purified by column chromatography. Upon application of the product to a pad of silica gel (2.5 x 8 cm) pre-equilibrated with CH2CI2, CH2Cl2 (100 mL) was used to elute impurities. The pure NHC-palladacycles were eluted with CH2Cl2-ethylacetate (3:1, vol/vol, 150 mL) and the solvents were evaporated. The products triturated with hexanes (25 mL). After drying in high vacuum, IPr-PdCl-[^jV, C-3, 5-(MeO)2BnNMe2] (491 mg, 68%) was obtained as yellow solid. 1H NMR (CDCl3, 400 MHz) delta: 7.39 (t, J= 7.6 Hz3 2H)5 7.27 (dd, J = 7.6, 1.6 Hz, 2H), 7.18 (dd, J= 7.6, 1.2 Hz, 2H)5 7.13 (s, 2H), 6.12 (d, J= 2.4 Hz, 3H), 5.99 (d, J= 2.4 Hz, 3H), 3.71 (s, 3H), 3.69 (m, 2H), 3.49 (s, 3H), 3.33 (s, 2H), 2.94 (m, 2H), 2.33 (s, 6H), 1.47 (d, J = 6.4 Hz, 6H), 1.18 (d, J = 6.8 Hz, 6H), 1.03 (d, J = 7.2 Hz, 6H), 0.99 (d, J= 6.4 Hz, 6H). 13C NMR (CDCl3, 100 MHz) delta: 175.5, 161.8, 157.4, 149.1, 148.2, 145.4, 136.8, 129.3, 127.9, 123.8, 123.7, 123.7, 99.9, 95.2, 73.4, 55.1, 54.9, 49.6, 29.0, 27.0, 26.6, 26.5, 24.2, 23.4., 250285-32-6

The synthetic route of 250285-32-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; WO2008/156451; (2008); A1;,
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New learning discoveries about 250285-32-6

250285-32-6, The synthetic route of 250285-32-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.250285-32-6,1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,as a common compound, the synthetic route is as follows.

IPr-HCI (82.04 mg, 0.193 mmol), [Pd(cin)(M-CI)]2 (50.0 mg, 0.096 mmol), a magnetic stir bar and acetone (0.8 mL) were charged into a vial . The mixture was stirred at 60 C for 1 h . The solvent was removed and the product was dried under vacuum . The product was obtained as a dark orange powder in a 99% ( 132 mg) yield . Single crystals were grown by vapour diffusion of hex- ane into a solution of the complex in DCM . XH IMMR (400 MHz, CDCh) : delta (ppm) = 9.19 (s, 1 H), 8.32 (d, J = 1.60 Hz, 2H), 7.56-7.52 (m, 2H), 7.46 (d, J = 7.44 Hz, 2H), 7.33 (d, J = 7.75 Hz, 4H), 7.21 (m, 3H), 5.66 (s, 1 H), 4.46 (s, 1 H), 3.83 (s, 1 H), 2.90 (s, 1 H), 2.48- 2.41 (m, 4H), 1.27 (d, J = 6.81 Hz, 12H), 1.19 (d, J = 6.76 Hz, 12H) . 13C {XH } NMR (100 MHz, CDCh): delta (ppm) = delta 144.9 (C), 136.7 (CH), 131.8 (C), 129.7 (C), 128.4 (CH), 127.7 (CH), 127.5 (CH), 124.5 (CH), 105.0 (C), 28.8 (CHs), 24.4 (CHs), 23.7 (CHs) . Elemental analysis: Expected : C 63.02, H 7.05 N 4.08 Found : C 62.92 H 7.14 N 4.15

250285-32-6, The synthetic route of 250285-32-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UMICORE AG & CO. KG; NOLAN, Steven P.; (47 pag.)WO2018/115029; (2018); A1;,
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Some tips on 250285-32-6

250285-32-6, As the paragraph descriping shows that 250285-32-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.250285-32-6,1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,as a common compound, the synthetic route is as follows.

General procedure: Under a N2 atmosphere, a mixture of imidazolium salts 1(0.225 mmol), PdCl2 (0.15 mmol), K2CO3 (0.45 mmol) and picolinicacid 2 (0.15 mmol) was stirred in anhydrous THF (2.0 mL) underreux for 12 h. Then the solvent was removed under reducedpressure, and the residue was puried by ash column chroma-tography (SiO2) to give complexes 3 as yellow solids. 4.2.1.1. Compound 3a. yellow solid. m.p. 248C (decomposed).1HNMR (500 MHz, CDCl3, TMS) d 8.55 (d, J 5.5 Hz, 1H), 7.83e7.77 (m,2H), 7.49 (t, J 7.5 Hz, 2H), 7.34 (d, J 7.5 Hz, 4H), 7.31e7.28 (m,1H),7.17 (s, 2H), 2.95 (hept, J 7.0 Hz, 4H), 1.42 (d, J 7.0 Hz, 12H), 1.14(d, J 7.0 Hz, 12H).13C NMR (125 MHz, CDCl3) d 172.7, 157.4, 151.3,146.8, 146.5, 139.1, 134.5, 130.4, 126.6, 126.2, 125.1, 124.0, 28.6, 26.2,22.9. IR (neat) n 2964, 1668, 1600, 1458, 1408, 1337, 1291, 1047, 944,800, 771, 755, 713 cm1. HRMS (ESI) calcd for C33H41ClN3O2Pd[MH]: 654.1920; found: 654.1917. Anal. calcd forC33H40ClN3O2Pd: C, 60.47%; H, 6.18%; N, 6.44%; found: C, 60.62%; H,6.11%; N, 6.31%.

250285-32-6, As the paragraph descriping shows that 250285-32-6 is playing an increasingly important role.

Reference£º
Article; Zhang, Zhi-Mao; Gao, Yu-Jue; Lu, Jian-Mei; Tetrahedron; vol. 73; 52; (2017); p. 7308 – 7314;,
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Some tips on 250285-32-6

As the paragraph descriping shows that 250285-32-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.250285-32-6,1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,as a common compound, the synthetic route is as follows.

Under the protection of nitrogen, to the reaction tube is sequentially added imidazole salt IPr¡¤HCl (1.1mmol), palladium chloride (1.0mmol), potassium carbonate (2.2mmol), tetrahydrofuran (5.0 ml) and isoquinoline (2.0mmol). The mixture is placed in the oil bath heated reaction (80 C) 12 hours. Stopping the reaction, cooling to room temperature, pressure reducing turns on lathe does solvent, rapid column chromatography separation to obtain a yellow solid product 0.1148g, yield 83%., 250285-32-6

As the paragraph descriping shows that 250285-32-6 is playing an increasingly important role.

Reference£º
Patent; Wenzhou University; Shao Lixiong; Lu Jianmei; Liu Feng; (23 pag.)CN106892945; (2017); A;,
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Brief introduction of 250285-32-6

250285-32-6 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride 2734913, achiral-catalyst compound, is more and more widely used in various fields.

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A 20 mL vial was charged with the NHC¡¤HCl (300 mg, 1 equiv.) and the zinc salt (1 equiv.). Tetrahydrofuran (5 mL) was added, the vial was sealed with a screw-cap and the reaction was stirred at 60C for two hours. The mixture was allowed to reach room temperature and the solvent was removed under reduced pressure toafford the desired product., 250285-32-6

250285-32-6 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride 2734913, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Santoro, Orlando; Nahra, Fady; Cordes, David B.; Slawin, Alexandra M.Z.; Nolan, Steven P.; Cazin, Catherine S.J.; Journal of Molecular Catalysis A: Chemical; vol. 423; (2016); p. 85 – 91;,
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Extracurricular laboratory: Synthetic route of 250285-32-6

As the rapid development of chemical substances, we look forward to future research findings about 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, cas is 250285-32-6, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,250285-32-6

A mixture of 1,3-bis(2,6-diisopropylphenyl)imidazolium chloride(0.425 g, 1.0 mmol), [Cp*IrCl2]2 (0.398 g, 0.5 mmol), and K2CO3(0.484 g, 3.5 mmol) in anhyd THF (8 mL)-CH2Cl2 (2 mL) wasstirred at 24 C for 10 h under N2. The resulting suspension wasstirred at 60 C for 24 h under N2, then concentrated to dryness. Afterthe addition of CH2Cl2 (10 mL) to the residue, the resulting suspensionwas filtered through Celite. The filtrate was concentrated todryness to give the iridium complex 2 as a brownish orange solid(0.748 g, 0.963 mmol, 96%).IR (ATR, ZnSe): 1659 cm-1 (CO2).1H NMR (500 MHz, CD2Cl2): delta = 7.43 (t, J = 8.0 Hz, 2 H), 7.33 (d,J = 8.0 Hz, 4 H), 7.09 (s, 2 H), 2.99-2.94 (m, 4 H), 1.45 (d, J = 7.0Hz, 12 H), 1.21 (s, 15 H), 1.06 (d, J = 6.0 Hz, 12 H).13C{1H} NMR (126 MHz, CD2Cl2): delta = 168.1, 165.9, 138.1, 130.1,126.4, 124.2, 87.2, 29.0, 27.2, 23.5, 9.4.Anal. Calcd for C38H51IrN2O3¡¤H2O: C, 57.48; H, 6.73; N, 3.53.Found: C, 57.40; H, 6.54; N, 3.57.

As the rapid development of chemical substances, we look forward to future research findings about 250285-32-6

Reference£º
Article; Yamada, Yoichim. A.; Ohta, Hidetoshi; Yuyama, Yoshinari; Uozumi, Yasuhiro; Synthesis; vol. 45; 15; (2013); p. 2093 – 2100;,
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Some tips on 250285-32-6

250285-32-6, As the paragraph descriping shows that 250285-32-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.250285-32-6,1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,as a common compound, the synthetic route is as follows.

Tris [4- (pyridin-4-yl) phenyl] amine compound (47.6 mg, 0.10 mmol)1,3-bis (2,6-diisopropylphenyl) imidazolium chloride (IPr.HCl) (127.5 mg, 0.30 mmol),PdCl2 (53.2 mg, 0.30 mmol)And potassium carbonate (41.5 mg, 0.30 mmol) were added to a 25 mL single neck flask,Tetrahydrofuran (5 mL) was then added,The reaction was stirred at 65 C for 16 h under argon atmosphere.Stop the reaction,Cool to room temperature,concentrate,Thin layer chromatography to give compound I,Yield 57%.

250285-32-6, As the paragraph descriping shows that 250285-32-6 is playing an increasingly important role.

Reference£º
Patent; Shangqiu Normal University; Wang Tao; Xu Kai; Liu Lantao; Zhao Wenxian; Liu Shuang; Li Feng; Meng Tuanjie; Xie Huanping; (12 pag.)CN105131044; (2017); B;,
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Extracurricular laboratory: Synthetic route of 250285-32-6

As the rapid development of chemical substances, we look forward to future research findings about 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, cas is 250285-32-6, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,250285-32-6

General procedure: 4.23.1. [1,3-Bis(2,6-di-iso-propylphenyl)imidazol-2-ylidene] copper(I) chloride, (IPr)CuCl [23] An oven-dried Schlenk flask containing 1,3-bis(2,6-di-iso-propylphenyl) imidazolium chloride (849.0 mg, 2.00 mmol), CuCl (198.0 mg, 2.00 mmol), NaOt-Bu (192.0 mg, 2.00 mmol) was evacuated and refilled with argon three times. THF (10 mL) were added to this Schlenk flask. The resulting suspension was stirred at room temperature for 4 h. Then, it was filtered through Celite in glovebox. Yield: 81%; white powder; IR (KBr): 3160, 3137, 3070, 2968, 2926, 2869, 1963, 1577, 1469, 1456, 1405, 1383, 1327, 1114, 1104, 1212, 1058, 937, 946, 809, 765, 742, 699 cm 1; 1H NMR (400 MHz, CDCl3): d = 7.48 (t, J = 8.0 Hz, 2H), 7.29 (d, J = 7.6 Hz, 4H), 7.11 (s, 2H), 2.53-2.60 (m, 4H), 1.30 (d, J = 12 Hz, 12H), 1.22 (d, J = 6.8 Hz, 12H); 13C NMR (100 MHz, CDCl3): d = 180.6, 145.6, 134.4, 130.6, 124.2, 123.2, 28.8, 24.9, 23.9.

As the rapid development of chemical substances, we look forward to future research findings about 250285-32-6

Reference£º
Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
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Some tips on 250285-32-6

As the paragraph descriping shows that 250285-32-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.250285-32-6,1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,as a common compound, the synthetic route is as follows.

General procedure: A mixture of pyrazine ligand 1 or 2 (1mmol), Li2PdCl4 (1mmol) and NaOAc (1mmol) in 20mL of dry methanol was stirred for 24hat rt. The yellow solids (yield: 92%) were collected by filtration and washed several times with methanol, which can be assigned to be palladacyclic dimers. Then, a Schlenk tube was charged with the above chloride-bridged palladacyclic dimers (0.5mmol), the corresponding imidazolium salt (1.25mmol) and tBuOK (2.5mmol) under nitrogen. Dry THF was added by a cannula and stirred at room temperature for 3h. The product was separated by passing through a short silica gel column with CH2Cl2 as eluent, the third band was collected and afforded the corresponding carbene adducts 3-10 as yellow solids. The characterization data for 3: Yield: 78%., 250285-32-6

As the paragraph descriping shows that 250285-32-6 is playing an increasingly important role.

Reference£º
Article; Xu, Chen; Wang, Zhi-Qiang; Fu, Wei-Jun; Ji, Bao-Ming; Yuan, Xiao-Er; Han, Xin; Xiao, Zhi-Qiang; Hao, Xin-Qi; Song, Mao-Ping; Journal of Organometallic Chemistry; vol. 777; (2015); p. 1 – 5;,
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