Category: 33100-27-5

33100-27-5, Name is 1,4,7,10,13-Pentaoxacyclopentadecane, molecular formula is C10H20O5, belongs to chiral-catalyst compound, is a common compound. In a patnet, once mentioned the new application about 33100-27-5, Computed Properties of C10H20O5

The invention concerns a compound of the formula I, wherein Ar1 is optionally substituted phenyl or naphthyl; A1 is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; Ar2 is optionally substituted phenylene, or a 6 membered heterocyclene moiety containing up to three nitrogen atoms; R1 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; wherein R2 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl; and wherein R3 is hydroxy-(1-4C)alkyl, mercapto-(1-4C)alkyl, (1-4C)alkoxy-(1-4C)alkyl, (3-4C)alkenyloxy-(1-4C)alkyl, (3-4C)alkynyloxy-(1-4C)alkyl, (1-4C)alkoxy-(2-4C)alkoxy-(1-4C)alkyl, (1-4C)alkylthio-(1-4C)alkyl, (1-4C)alkylsulphinyl-(1-4C)alkyl, (1-4C)alkylsulphonyl-(1-4C)alkyl, (1-4C)alkoxycarbonyl-(1-4C)alkyl, (2-4C)alkanoyl-(1-4C)alkyl, (2-4C)alkanoyloxy-(1-4C)alkyl or cyano-(1-4C)alkyl; or R3 is oxiranyl, oxetanyl, tetrahydrofuranyl or tetrahydropyranyl; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Computed Properties of C10H20O5. In my other articles, you can also check out more blogs about 33100-27-5

Reference：
Chiral Catalysts,
Chiral catalysts – SlideShare

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Sodium thiocyanate reacts in THF solution with 18-crown-6 to give the molecular compound Na(18-crown-6)(THF)NCS (3) with the N atom of the NCS anion oriented towards Na1+. The same reaction with 15-crown-5 yields the ion pair Na(15-crown-5)NCS (4). In contrast, Na(NCS)(py)4, obtained by treating a solution of Na(H3BNCS) in THF with pyridine, yields Na(py)4(NCS) (5), which has a chain structure with hexacoordinate Na atoms coordinated to five N atoms and an S atom. Na(NCS) in THF adds 1 equiv. of BH3 to give Na(H3BNCS)*nTHF. Addition of 18-crown-6 to this solution yields crystals of the salt [Na(18-crown-6)(THF)2][H3BNCS] (1), as shown by X-ray crystallography. Both the cation and the anion show site disorder. However, when 15-crown-5 is used for complexation, the salt [Na(15-crown-5)(THF)][H3BNCS] (2) can be isolated. Its anion shows an almost linear B-N-C-S unit. Only a mixture of (catecholato)(isothiocyanato)borates results on treating Na(NCS) in THF with catecholborane. However, the borate Na[catB(NCS)2] is readily formed by adding Na(NCS) to B-(isothiocyanato)catecholborane. Single crystals of this compound were obtained as the salt [Na(18-crown-6)(THF)2][catB(NCS)2] (6). On the other hand, the reaction of Na(NCS) with 9-borabicyclo[3.3.1]nonane (9-BBN) in THF yields Na[(9-BBN)NCS]*nTHF, and, on addition of 18-crown-6, the complex [Na(18-crown-6)(THF)2][(9-BBN)NCS] was isolated. Suitable crystal for X-ray structure determination were, however, only obtained by crystallization from tetrahydropyran. This solvate has the rather unusual structure [Na(18-crown-6)(thp)2][{(9-BBN)NC}2Na(thp)4] (8). The sodiate anion has an Na atom coordinated by two S and four O atoms. DFT calculations support these experimental results: The (isothiocyanato)borates are more stable than the thiocyanato isomers. For the latter a bent structure of the B-S-C-N unit with a B-S-C bond angle of 105.7 deg is predicted.

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Chiral Catalysts,
Chiral catalysts – SlideShare

Application of 33100-27-5. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 33100-27-5, Name is 1,4,7,10,13-Pentaoxacyclopentadecane. In a document type is Article, introducing its new discovery.

The interaction of five crown ethers, 15-crown-5, 18-crown-6, benzo-15-crown-5, dibenzo-18-crown-6, and dibenzo-24-crown-8 with 2,3,5,6 – tetracyano pyrazine has been studied by spectroscopic methods.The association constants and thermodynamic parameters of the 1:1 complexes formed by donor ethers with the acceptor have been evaluated.There is an indication that oxygens of the ethers and aryl part of the ether act cooperatively in binding of the acceptor.

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Chiral Catalysts,
Chiral catalysts – SlideShare

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Novel oxamide derivatives are described which inhibit the production of TNF and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful as inhibitors of PDE IV and are therefor useful in the treatment of disease states mediated or exacerbated thereby

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Chiral Catalysts,
Chiral catalysts – SlideShare

Application of 33100-27-5. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 33100-27-5, Name is 1,4,7,10,13-Pentaoxacyclopentadecane

The apparent molar volumes and adiabatic compressibilities of 18-Crown-6, 15-Crown-5, 12-Crown-4, tetraglyme, and triglyme were measured at 25C in H2O and D2O. The contribution of the -CH2CH2O- group to the limiting partial molar volumes and compressibilities of cyclic and open-chain ethers in both solvents are compared and solvent isotope effects calculated. It is concluded, based on the compressibility results, that there is a subtle difference between the hydration of the ethene oxide group in cyclic and open-chain ethers and that this difference persists in D2O. These results indicate that the calculation of limiting apparent molar compressibilities using additivity schemes will have to account for whether the group is in a cyclic or open-chain compound.

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Reference：
Chiral Catalysts,
Chiral catalysts – SlideShare

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Following the isolation from marine sponges, in 1993, of a family of related highly oxygenated macrolactones named spongistatins, altohyrtins and cinachyrolides, impressive synthetic efforts have been devoted to the synthesis of these macrolides. Their highly potent activity as cancer cells growth inhibitors combined with a fascinating and complex architecture has prompted synthetic organic chemists to develop efficient routes to these molecules. From the first total syntheses by the groups of Evans and Kishi in 1997 and 1998 which delivered milligram quantities of spongistatins/altohyrtins, further intensive studies have led to new pathways with practical solution to provide gram scale amounts of key intermediates. The present review focuses on biological properties and synthetic issues related to these marine macrolides.

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Chiral Catalysts,
Chiral catalysts – SlideShare

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Daly, Scott R. and a compound is mentioned, 33100-27-5, 1,4,7,10,13-Pentaoxacyclopentadecane, introducing its new discovery. 33100-27-5

The reaction of a slurry of BaBr2 in a minimal amount of tetrahydrofuran (THF) with 2 equiv of Na(H3BNMe2BH 3) in diethyl ether followed by crystallization from diethyl ether at -20 C yields crystals of Ba(H3BNMe2BH 3)2(Et2O)2 (1). Drying 1 at room temperature under vacuum gives the partially desolvated analogue Ba(H 3BNMe2BH3)2(Et2O) x (1?) as a free-flowing white solid, where the value of x varies from <0.1 to about 0.4 depending on whether desolvation is carried out with or without heating. The reaction of 1 or 1? with Lewis bases that bind more strongly to barium than diethyl ether results in the formation of new complexes Ba(H3BNMe2BH3)2(L), where L = 1,2-dimethoxyethane (2), N,N,N?,N?-tetramethylethylenediamine (3), 12-crown-4 (4), 18-crown-6 (5), N,N,N?,N?- tetraethylethylenediamine (6), and N,N,N?,N?,N?- pentamethylethylenetriamine (7). Recrystallization of 4 and 5 from THF affords the related compounds Ba(H3BNMe2BH3) 2(12-crown-4)(THF) ·THF (4?) and Ba(H 3BNMe2BH3)2(18-crown-6) ·2THF (5?). In addition, the reaction of BaBr2 with 2 equiv of Na(H3BNMe2BH3) in the presence of diglyme yields Ba(H3BNMe2BH3)2(diglyme) 2 (8), and the reaction of 1 with 15-crown-5 affords the diadduct [Ba(15-crown-5)2][H3BNMe2BH3] 2 (9). Finally, the reaction of BaBr2 with Na(H 3BNMe2BH3) in THF, followed by the addition of 12-crown-4, affords the unusual salt [Na(12-crown-4)2][Ba(H 3BNMe2BH3)3(THF)2] (10). All of these complexes have been characterized by IR and 1H and 11B NMR spectroscopy, and the structures of compounds 1-3, 4?, 5?, and 6-10 have been determined by single-crystal X-ray diffraction. As the steric demand of the Lewis bases increases, the structure changes from polymers to dimers to monomers and then to charge-separated species. Despite the fact that several of the barium complexes are monomeric in the solid state, none is appreciably volatile up to 200 C at 10-2 Torr. Interested yet? Read on for other articles about 33100-27-5!, 33100-27-5

Reference：
Chiral Catalysts,
Chiral catalysts – SlideShare

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The interactions of 18-crown-6, 15-crown-5, and 12-crown-4 with Na+ and K+ were studied in methanol and water as solvents at 25 deg C. DeltaG0 values for both 1:1 and 2:1 complexation reactions were determined by potentiometric titrations.Used in conjunction with these values, calorimetric measurements led to DeltaH0 and DeltaS0 values.The thermodynamic parameters obtained cannot be correlated with the cations or the crown ethers “hole” sizes in any 1:1 or 2:1 reactions.Moreover, the DeltaG0 values are the results of quite different but permanently compensating combinations of the DeltaH0 and DeltaS0 values.These arise from several thermodynamic processes in which the role of the solvent must be considered.In the case of 18-crown-6, we present a quantitative interpretation in which this crown ether develops interactions that are stronger with Na+ than with K+.

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Reference：
Chiral Catalysts,
Chiral catalysts – SlideShare

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The titanium(IV) complexes of 12-crown-4, 15-crown-5 and 18-crown-6 and of 1,4-dithia-7,10,13-trioxacyclopentadecane (L?) of type [TiX4(eta2-L)] (X = Cl or Br, L = 15-crown-5 or 18-crown-6; X = Br, L = 12-crown-4) and [TiCl4(L?)] have been prepared from TiX4 and the ligands in anhydrous toluene, and characterised by analysis, IR, UV-visible and 1H NMR spectroscopy. Complexes with TiI4 do not form under similar conditions. The [TiCl4(L?)] complex contains the thia-oxa-crown coordinated via sulfur to the titanium. The complexes are extremely readily hydrolysed and examples of the first two stages of the hydrolysis have been characterised by X-ray crystallography. These are the dimer [(18-crown-6)Cl3Ti(mu-O)TiCl3(18-crown-6)] which contains a single non-linear oxo-bridge linking two six-coordinate titanium centres also coordinated eta2 to 18-crown-6 and to three (mer) chlorines. The second product is the tetrameric [{TiOCl2(15-crown-5)}4] in which there is an eight-membered ring composed of alternating Ti and O, each titanium also coordinated eta2 to 15-crown-5 and two terminal (cis) chlorines.

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Reference：
Chiral Catalysts,
Chiral catalysts – SlideShare

33100-27-5, Name is 1,4,7,10,13-Pentaoxacyclopentadecane, molecular formula is C10H20O5, belongs to chiral-catalyst compound, is a common compound. In a patnet, once mentioned the new application about 33100-27-5, category: chiral-catalyst

A series of crown ethers were synthesized from the reaction of 1,8-dichloro-3,6-dioxaoctane with the appropriate hydroxy compound under microwave irradiation in short times and high yields. Copyright Taylor & Francis Group, LLC.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.category: chiral-catalyst. In my other articles, you can also check out more blogs about 33100-27-5

Reference：
Chiral Catalysts,
Chiral catalysts – SlideShare