Category: 33100-27-5

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 33100-27-5, Name is 1,4,7,10,13-Pentaoxacyclopentadecane, 33100-27-5.

Synthesis of mono- and bi-layer zeolite films on alumina substrates

Bilayer zeolite films ZSM-5/ZSM-5, ZSM-5/EMC-1 and NaY/ZSM-5 were synthesized on alpha-alumina plates. The bottom ZSM-5 or faujasite Y (NaY) zeolite layers were obtained by direct hydrothermal synthesis or by using a seeding step followed by a secondary growth method, respectively, while the secondary growth method was used for the synthesis of all the top zeolite layers. A complete characterization of the obtained materials is proposed using various techniques, such as X-ray diffraction, scanning electron microscopy, X-ray fluorescence and nitrogen sorption measurements. Continuous and highly crystallized bi-layer zeolite films with thicknesses around 11-18 mum were obtained.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.33100-27-5. In my other articles, you can also check out more blogs about 33100-27-5

Reference£º
Chiral Catalysts,
Chiral catalysts – SlideShare

 

1,4,7,10,13-Pentaoxacyclopentadecane, cas is 33100-27-5, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,33100-27-5

Sodium hydride (60percent dispersion in mineral oil, 0.14 g) was added portionwise to a stirred solution of a portion (0.87 g) of the 3-hydroxypyrrolidine so obtained and 1,4,7,10,13-pentaoxacyclopentadecane (hereinafter 15-crown-5, 0.05 g) in DMF (10 ml). The mixture was stirred at ambient temperature for 15 minutes. A solution of methyl 4-toluenesulphonate (0-56 g) in THF (2 ml) was added dropwise and the mixture was stirred at ambient temperature for 2 hours. The mixture was partitioned between diethyl ether and water. The organic phase was dried (Na2 SO4) and evaporated. The residue was purified by column chromatography using increasingly polar mixtures of hexane and ethyl acetate as eluent. There was thus obtained 1-benzyl-3-(3,5-difluorophenyl)-3-methoxypyrrolidine (0.82 g, 90percent).

33100-27-5 is used more and more widely, we look forward to future research findings about 1,4,7,10,13-Pentaoxacyclopentadecane

Reference£º
Patent; Zeneca Limited; Zeneca Pharma S.A.; US5420298; (1995); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33100-27-5,1,4,7,10,13-Pentaoxacyclopentadecane,as a common compound, the synthetic route is as follows.

EXAMPLE 1 A mixture of 4-hydroxy-4-[3-(naphth-2-ylmethoxy)phenyl]-tetrahydropyran (1.9 g), sodium hydride (0.27 g of a 50percent w/w dispersion in mineral oil), 1,4,7,10,13-pentaoxacyclopentadecane (hereinafter 15-crown-5, 0.2 g) and tetrahydrofuran (10 ml) was stirred at ambient temperature for 15 minutes. Methyl iodide (0.35 ml) was added and the mixture was stirred at ambient temperature for 15 hours. The mixture was evaporated and the residue was partitioned between diethyl ether and water. The organic layer was separated, washed with a saturated aqueous sodium chloride solution, dried (MgSO4) and evaporated. The residue was purified by column chromatography using a 9:1 v/v mixture of methylene chloride and diethyl ether as eluent. There was thus obtained 4-methoxy-4-[3-(naphth-2-ylmethoxy)phenyl]tetrahydropyran (1.8 g, 94percent), m.p. 66.5¡ã-67.5¡ã C. The 4-hydroxy-4-[3-(naphth-2-ylmethoxy)phenyl]tetrahydropyran starting material was obtained as follows:, 33100-27-5

The synthetic route of 33100-27-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Imperial Chemical Industries PLC; ICI Pharma; US5098930; (1992); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

 

It is a common heterocyclic compound, the chiral-catalyst compound, 1,4,7,10,13-Pentaoxacyclopentadecane, cas is 33100-27-5 its synthesis route is as follows.,33100-27-5

A mixture of 2-(3-methoxymethoxyphenyl)butane-1,2-diol (16.3 g), sodium hydride (8.74 g of a 50percent w/w dispersion in mineral oil) and dimethylformamide (160 ml) was stirred at ambient temperature for 15 minutes. Methyl iodide (41.3 g) and 1,4,7,10,13-pentaoxacyclopentadecane (hereinafter 15-crown-5, 0.5 g) were added and the mixture was stirred at ambient temperature for 15 hours. The mixture was evaporated and the residue was partitioned between methylene chloride and water. The organic layer was separated, washed with water, dried (MgSO4) and evaporated. There was thus obtained 2-methoxy-2-(3-methoxymethoxyphenyl)but-1-yl methyl ether as an oil (16.3 g, 95percent).

With the complex challenges of chemical substances, we look forward to future research findings about 1,4,7,10,13-Pentaoxacyclopentadecane

Reference£º
Patent; Imperial Chemical Industries PLC; ICI Pharma; US5202326; (1993); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

 

Name is 1,4,7,10,13-Pentaoxacyclopentadecane, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 33100-27-5, its synthesis route is as follows.,33100-27-5

General procedure: Crystals of compounds 1?3 were prepared by isothermal evaporation fromaqueous solutions at room temperature. The crystals of compound 1 weresynthesized by the reaction of 0.051 g (0.1 mmol) of UO2(NO3)2¡¤6H2O,0.040 g (0.22 mmol) of 12-crown-4, 0.280 g (2.0 mmol) of 40percent H2SeO4,and 2.001 g (111.2 mmol) of deionized distilled water. Compound 2:0.050 g (0.1 mmol) of uranyl nitrate, 0.046 g (0.21 mmol) of 15-crown-5,0.282 g (2.0 mmol) of selenic acid, and 2.012 g (111.7 mmol) of deionizeddistilled water. Compound 3: 0.050 g (0.1 mmol) of uranyl nitrate, 0.046 g(0.21 mmol) of 15-crown-5, 0.282 g (2.0 mmol) of selenic acid, and 2.012 g(111.7 mmol) of deionized distilled water (note: the bulk of crystals herebelongs to compound 2). Homogeneous liquid solutions were left in awatch glass. Yellowish-green flattened crystals formed within 2 weeks.

With the complex challenges of chemical substances, we look forward to future research findings about 1,4,7,10,13-Pentaoxacyclopentadecane

Reference£º
Article; Gurzhiy, Vladislav V.; Tyumentseva, Olga S.; Tyshchenko, Darya V.; Krivovichev, Sergey V.; Tananaev, Ivan G.; Mendeleev Communications; vol. 26; 4; (2016); p. 309 – 311;,
Chiral Catalysts
Chiral catalysts – SlideShare

 

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO18,mainly used in chemical industry, its synthesis route is as follows.,33100-27-5

EXAMPLE 1 A mixture of 4-hydroxy-4-[3-(naphth-2-ylmethoxy)phenyl]-tetrahydropyran (1.9 g), sodium hydride (0.27 g of a 50percent w/w dispersion in mineral oil), 1,4,7,10,13-pentaoxacyclopentadecane (hereinafter 15-crown-5, 0.2 g) and tetrahydrofuran (10 ml) was stirred at ambient temperature for 15 minutes. Methyl iodide (0.35 ml) was added and the mixture was stirred at ambient temperature for 15 hours. The mixture was evaporated and the residue was partitioned between diethyl ether and water. The organic layer was separated, washed with a saturated aqueous sodium chloride solution, dried (MgSO4) and evaporated. The residue was purified by column chromatography using a 9:1 v/v mixture of methylene chloride and diethyl ether as eluent. There was thus obtained 4-methoxy-4-[3-(naphth-2-ylmethoxy)phenyl]tetrahydropyran (1.8 g, 94percent), m.p. 66.5¡ã-67.5¡ã C. The 4-hydroxy-4-[3-(naphth-2-ylmethoxy)phenyl]tetrahydropyran starting material was obtained as follows:

With the synthetic route has been constantly updated, we look forward to future research findings about 1,4,7,10,13-Pentaoxacyclopentadecane,belong chiral-catalyst compound

Reference£º
Patent; Imperial Chemical Industries PLC; ICI Pharma; US5098930; (1992); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

 

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO459,mainly used in chemical industry, its synthesis route is as follows.,33100-27-5

[(15-Crown-5)Na][Br] Used in CORM-365; 1.070 g (4.86 mmol) of 15-Crown-5 (commercially available) and 500 mg (3.78 mmol) of NaBr were stirred together in 15 ml: of methanol at 50¡ã C. for 3 hrs. Following this, the solvent was removed on rotary, evaporator to give a solid product that was washed several times with ether and then dried under vacuum.1.317 g of a white solid was obtained. Yield was 83.9percent.

With the synthetic route has been constantly updated, we look forward to future research findings about 1,4,7,10,13-Pentaoxacyclopentadecane,belong chiral-catalyst compound

Reference£º
Patent; Motterlini, Roberto Angelo; Mann, Brian Ernest; Scapens, David Alistair; US2010/105770; (2010); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

 

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO297,mainly used in chemical industry, its synthesis route is as follows.,33100-27-5

General procedure: A solution of (2 mmol, 0.4 ml) of 15-crown-5 in (10 ml) of absolute ethanol was added to a solution of (1 mmol, 0.933 gm Pr-picrate), (0.936 gm Nd-picrate) and (0.900 gm Dy-picrate) in (10 ml) of absolute ethanol and refluxed at (50 ? 60 oC) for (1 hr.). The solution was concentrated at (40 ? 50 oC) to a very small volume (till the formation of a precipitate), usually a gummy precipitate forms which was treated with (40 ? 60 oC) petroleum ether until all the gummy precipitate was converted to a fine yellow ? orange powder. The precipitate was collected and stored in a desicator for complete dryness. These complexes were also prepared by another method, by stirring a solution of 15-crown-5 with a solution of lanthanide picrate for (24 ? 48 hrs.). The gummy precipitates were treated with petroleum ether. The yields were (92 ? 96percent)24.

With the synthetic route has been constantly updated, we look forward to future research findings about 1,4,7,10,13-Pentaoxacyclopentadecane,belong chiral-catalyst compound

Reference£º
Article; Al-Amery, Mohammed H. A.; Al-Abdaly, B. Ibrahim; Albayaty, M. Kahtan; Oriental Journal of Chemistry; vol. 32; 2; (2016); p. 1025 – 1048;,
Chiral Catalysts
Chiral catalysts – SlideShare

 

Name is 1,4,7,10,13-Pentaoxacyclopentadecane, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 33100-27-5, its synthesis route is as follows.

The (2S,4R)-4-(tert-butyldimethylsilyloxy)-4-[3-(8-chloro-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)phenyl]-2-methyltetrahydropyran used as a starting material was obtained as follows: Sodium hydride (50percent dispersion in mineral oil, 0.3 g) was added portionwise to a stirred mixture of (2S,4R)-4-hydroxy-4-(3-iodophenyl)-2-methyltetrahydropyran (1.64 g), 1,4,7,10,13-pentaoxacyclopentadecane (hereinafter 15-crown-5, 0.05 g) and THF (30 ml) and the mixture was stirred at ambient temperature for 30 minutes. Tert-butyldimethylsilyl chloride (0.9 g) was added and the mixture was stirred and heated to 60¡ã C. for 6 hours. The mixture was cooled to ambient temperature and partitioned between diethyl ether and a dilute aqueous ammonium chloride solution. The organic solution was washed with brine, dried (Na2 SO4) and evaporated. The residue was purified by column chromatography using increasingly polar mixtures of hexane and ethyl acetate as eluent. There was thus obtained (2S,4R)-4-(tert-butyldimethylsilyloxy)-4-(3-iodophenyl)-2-methyltetrahydropyran (1.9 g, 88percent) as an oil.

33100-27-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,33100-27-5 ,1,4,7,10,13-Pentaoxacyclopentadecane, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Zeneca Limited; Zeneca Pharma S.A.; US5478842; (1995); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33100-27-5,1,4,7,10,13-Pentaoxacyclopentadecane,as a common compound, the synthetic route is as follows.

[0083] (S) N-(Acetoxymethyl)-N-[(1R,2S,5R)-menthyloxycarbonyl]-4-(1,4,7,10-tetraoxa-13-azacyclopentadecan-13-yl)homoalanine methyl ester (53): A solution of the aldehyde (40) (78 mg, 0.20 mmol) in dry dichloroethane (3 mL) wastreated with 1-aza-15-crown-5 (58 mg, 0.26 mmol) and triethylamine (38 mL, 0.27 mmol) and stirred for 10 min. at 26¡ãC. Then sodium (triacetoxy)borohydride (69 mg, 0.32 mmol) was added and the stirring continued for 2.5 h. After usualwork-up and concentration, the residue was purified by rotatory chromatography (hexane/EtOAc, 98:2), yielding theproduct (53) (108 mg, 91percent) as a yellowish slurry: [alpha]D =-51.22 (c 0.41, CHCl3); 1H NMR (500 MHz, CDCl3, 70 ¡ãC) deltaH0.77 (3H, d, J = 6.9 Hz, Me), 0.80-0.90 (1 H, m, 4?-Ha), 0.88 (3H, d, J = 7.3 Hz, Me), 0.89 (3H, d, J = 6.6 Hz, Me), 0.96(1 H, m, 6?-Hb), 1.05 (1 H, m, 3?-Ha), 1.36 (1 H, m, 2?-H), 1.55 (1 H, m, 5?-H), 1.62-1.69 (2H, m, 4?-Hb + 3?-Hb), 1.86 (1H, m, 2″-H), 1.96 (1 H, m, 3-Ha), 2.00 (3H, s, Ac), 2.02 (1 H, m, 6?-Ha), 2.23 (1 H, m, 3-Hb), 2.57-2.69 (2H, m, 4-H2),2.72-2.82 (4H, m, 2 x CH2N), 3.58-3.64 (16H, m, 8 x CH2O), 3.66 (3H, s, OMe), 4.52 (1 H, br b, 2-H), 4.60 (1 H, ddd, J= 4.4, 10.8, 11.0 Hz, 1?-H), 5.35 (1 H, br d, J = 11.0 Hz, OCHaN), 5.45 (1 H, d, J = 11.0 Hz, OCHbN); 13C NMR (125.7MHz, CDCl3, 70 ¡ãC) deltaC 16.3 (CH3), 20.7 (CH3), 21.8 (CH3), 23.6 (CH2), 25.9 (CH), 28.0 (CH2), 31.4 (CH), 34.3 (CH2),41.1 (CH2), 47.4 (CH), 51.9 (CH3), 53.0 (CH2), 54.7 (2 x CH2), 58.3 (CH), 69.8 (2 x CH2), 70.3 (2 x CH2), 70.6 (2 x CH2),71.1 (2 x CH2), 76.7 (CH), 155.3 (C), 170.3 (C), 171.7 (C); MS (EI) m/z (relative intensity) 588 (M+, 1), 545 (M+ – CHMe2, 2), 529 (M+ – OAc, 4), 232 ([1-methylen-1-aza-15-crown-5]+, 100. HRMS calcd for C29H52N2O10, 588.3622, found588.3626; calculated for C26H45N2O10, 545.3074, found 545.3077; calculated for C25H41N2O10, 529.2761, found529.2758; calculated for C11H22NO4, 232.1549, found 232.1542. Elemental analysis: Calculated for C29H52N2O10: C,59.16; H, 8.90; N, 4.76; found C, 59.24; H, 8.90; N, 4.88., 33100-27-5

33100-27-5 1,4,7,10,13-Pentaoxacyclopentadecane 36336, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; Consejo Superior De Investigaciones Cientificas (CSIC); ROMERO ESTUDILLO, Ivan Omar; BOTO CASTRO, Alicia; EP2957555; (2015); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare