Category: 351498-10-7

6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol), cas is 351498-10-7, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,351498-10-7

In a nitrogen atmosphere, add to the reactor,2,2 ‘-[(1,1,2,2-tetramethyl-1,2-ethylenediyl) bis (nitromethyl)] bis [4,6-bis (1,1-dimethyl (Ethyl)] phenol, 16.46g (30mmol),21.6 g (152 mmol) of boron trifluoride-ether complex,300ml toluene20 g (152 mmol) of N, N-diisopropylethylamine was stirred with heating at 40 C for 2.5 hours.Cool to room temperature, add 300ml of water, and separate the filtrate into organic and aqueous layers.The organic layer was washed twice with a saturated sodium carbonate aqueous solution and dried over magnesium sulfate.The obtained solid was recrystallized from toluene (150 ml) and ethanol (750 ml),This gave 18.78 g of crude product. The crude product is under pressure 3 ¡Á 10-3Pa,Sublimation at a temperature of 225 C gave compound [69] (light yellow solid).

With the rapid development of chemical substances, we look forward to future research findings about 351498-10-7

Reference£º
Patent; TORAY ADVANCED MATERIALS RESEARCH LABORATORIES (CHINA) CO., LTD.; WAN, PENG; JIN, GUANGNAN; IKEDA, TAKESHI; LI, JINCAI; TANAKA, DAISAKU; (48 pag.)TW2019/25212; (2019); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol), cas is 351498-10-7, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,351498-10-7

N,N-Bis(3,5-di-tert-butylsalicylidene)-1 ,1 ,2,2-tetramethylethylenediamine (24, 0.73 g, 1 .3 mmol)was suspended in 10.0 mL of ethanol. The resulting suspension was heated to 80 c and stirred for 5minutes under argon balloon. Cobalt (II) acetate (0.24g, 1 .3 mmol) was then added, and the reactionmixture was stirred for another 2 hours at 80 00. The crimson red suspension was cooled down to roomtemperature in an ice bath and was filtered. The collected red solid was dried under vacuum to provide0.70 g of compound 25 (87%).

With the rapid development of chemical substances, we look forward to future research findings about 351498-10-7

Reference£º
Patent; SOLSTICE BIOLOGICS, LTD.; BRADSHAW, Curt, W.; SAKAMURI, Sukumar; LIU, Dingguo; (83 pag.)WO2016/94677; (2016); A2;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belong chiral-catalyst compound,6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),351498-10-7,Molecular formula: C36H56N2O2,mainly used in chemical industry, its synthesis route is as follows.,351498-10-7

EXAMPLE 1Preparation of Intermediate Compound Int-lclnt-1a n – c Compound Int-la (733 mg, 1.33 mmol) was suspended in ethanol (10 mL) and the resulting suspension was heated to 80 C and allowed to stir for 5 minutes. Compound Int- lb (236 mg, 1.33 mmol) was then added and the resulting reaction was allowed to stir at 80 C for an additional 2 hours. The reaction was then cooled to room temperature using in an ice bath and the reaction mixture was filtered. The collected red solid was dried under vacuum to provide compound Int-lc (579 mg, 72%).

With the synthetic route has been constantly updated, we look forward to future research findings about 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),belong chiral-catalyst compound

Reference£º
Patent; MERCK SHARP & DOHME CORP.; GIRIJAVALLABHAN, Vinay; NJOROGE, F. George; BOGEN, Stephane; VERMA, Vishal; BENNETT, Frank; KEREKES, Angela; ARASAPPAN, Ashok; PISSARNITSKI, Dmitri; DANG, Qun; DAVIES, Ian; OLSEN, David, B.; STAMFORD, Andrew; VACCA, Joseph, P.; WO2012/142085; (2012); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belong chiral-catalyst compound,6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),351498-10-7,Molecular formula: C36H56N2O2,mainly used in chemical industry, its synthesis route is as follows.,351498-10-7

Compound Int-1a (733 mg, 1.33 mmol) was suspended in ethanol (10 mL) and the resulting suspension was heated to 80 C and allowed to stir for 5 minutes. Compound Int- 1b (236 mg, 1.33 mmol) was then added and the resulting reaction was allowed to stir at 80 C for an additional 2 hours. The reaction was then cooled to room temperature using in an ice bath and the reaction mixture was filtered. The collected red solid was dried under vacuum to provide compound Int-1c (579 mg, 72%).

With the synthetic route has been constantly updated, we look forward to future research findings about 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),belong chiral-catalyst compound

Reference£º
Patent; MERCK SHARP & DOHME CORP.; GIRIJAVALLABHAN, Vinay; BOGEN, Stephane; TRUONG, Quang, T.; CHEN, Ping; KEREKES, Angela; BENNETT, Frank; ESPOSITE, Sara; HONG, Qingmei; DAVIES, Ian; WO2014/62596; (2014); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

351498-10-7, 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol) is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 1Preparation of Intermediate Compound Int-lclnt-1a n – c Compound Int-la (733 mg, 1.33 mmol) was suspended in ethanol (10 mL) and the resulting suspension was heated to 80 C and allowed to stir for 5 minutes. Compound Int- lb (236 mg, 1.33 mmol) was then added and the resulting reaction was allowed to stir at 80 C for an additional 2 hours. The reaction was then cooled to room temperature using in an ice bath and the reaction mixture was filtered. The collected red solid was dried under vacuum to provide compound Int-lc (579 mg, 72%).

The synthetic route of 351498-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; GIRIJAVALLABHAN, Vinay; NJOROGE, F. George; BOGEN, Stephane; VERMA, Vishal; BENNETT, Frank; KEREKES, Angela; ARASAPPAN, Ashok; PISSARNITSKI, Dmitri; DANG, Qun; DAVIES, Ian; OLSEN, David, B.; STAMFORD, Andrew; VACCA, Joseph, P.; WO2012/142085; (2012); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.351498-10-7,6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),as a common compound, the synthetic route is as follows.

Preparation of Cobalt(ll) Complex used in Step 2: A 50 mL flask was charged with lambda/,lambda/-bis(3,5-di-tert-butylsalicylidene)-1 , 1 ,2,2- tetramethylethenediamine (0.4302 g, 0.78 mmol, 1.0 equiv), EtOH (17 mL), and Co(OAc)2 (0.1385 g, 0.78 mmol, 1.0 equiv). The mixture was degassed and then heated to reflux under nitrogen for 3 h, cooled to room temperature. The precipitate was filtered and the purple solid was washed with EtOH (10 mL) and dried under high vacuum to give 0.3533 g (75%) of the cobalt(ll) complex.

351498-10-7 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol) 135404188, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Patent; VITAE PHARMACEUTICALS, INC.; WO2009/88997; (2009); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

351498-10-7, 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol) is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 50 mL flask was charged with N,N’-bis(3,5-di-tert-butylsalicylidene)-1,1,2,2-tetramethylethenediamine (0.430 g, 0.78 mmol, 1.0 equiv), EtOH (17 mL), and Co(OAc)2 (0.139 g, 0.78 mmol, 1.0 equiv). The mixture was degassed and then heated to reflux under nitrogen for 3 h, cooled to room temperature. The precipitate was filtered and the purple solid was washed with EtOH (10 mL) and dried under high vacuum to give 0.353 g (75%) of the cobalt(II) complex.

351498-10-7 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol) 135404188, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Patent; Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH; US2010/331320; (2010); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

351498-10-7, 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol) is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of N,N’-bis(3,5-di-tert-butylsalicylidene)-1,1,2,2-tetramethylethylenediamine (500 mg) in ethanol (20 mL) was refluxed under an argon atmosphere for 10 minutes. To the mixture was added cobalt (II) acetate (161 mg), and then the mixture was refluxed for 2 hours. The mixture was allowed to cool to room temperature and then the precipitate was collected by filtration. The obtained solid was washed with ethanol, and dried under reduced pressure to give the title compound (303 mg).

The synthetic route of 351498-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kissei Pharmaceutical Co., Ltd.; KONDO, Atsushi; MORITA, Naohide; ISHIKAWA, Takehiro; YOSHIDA, Masako; MORIYAMA, Akihiro; WANAJO, Isao; (158 pag.)EP3459941; (2019); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

351498-10-7, 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol) is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Cobalt catalyst 1 was prepared as follows: A 50 mL flask was charged with lambda/,/V’-bis(3,5-di-fert-butylsalicylidene)-1 ,1 ,2,2-tetramethylethenediamine (0.4302 g, 0.78 mmol, 1.0 equiv), EtOH (17 mL), and Co(OAc)2 (0.1385 g, 0.78 mmol, 1.0 equiv). The mixture was degassed and then heated to reflux under nitrogen for 3 h, cooled to room temperature. The precipitate was filtered and the purple solid was washed with EtOH (10 mL) and dried under high vacuum to give 0.3533 g (75%) of the cobalt(l I) complex. LC-MS Method 2 tR = 1.921 min, m/z = 440.1 ; 1H NMR (CD3OD) delta=1.25 (s, 3H), 1.49 (s, 3H), 2.04 (d, 3H), 2.34 (m, 2H), 2.38 (m, 1 H), 2.40 (m, 2H), 3.02 (m, 1H), 5.67 (m, 1 H), 6.97 (m, 2H), 7.26 (m, 3H), 7.38 (m, 4H).

As the paragraph descriping shows that 351498-10-7 is playing an increasingly important role.

Reference£º
Patent; VITAE PHARMACEUTICALS, INC.; WO2009/61498; (2009); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.351498-10-7,6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol),as a common compound, the synthetic route is as follows.

A 50 ml. flask was charged withLambda/,Lambda/-bis(3,5-di-te/t-butylsalicylidene)-1 ,1 ,2,2-tetramethylethenediamine (0.4302 g, 0.78 mmol, 1.0 equiv), EtOH (17 ml_), and Co(OAc)2 (0.1385 g, 0.78 mmol, 1.0 equiv). The mixture was degassed and then heated to reflux under nitrogen for 3 h, cooled to room temperature. The precipitate was filtered and the purple solid was washed with EtOH (10 ml.) and dried under high vacuum to give 0.3533 g (75%) of the cobalt(ll) complex.

As the paragraph descriping shows that 351498-10-7 is playing an increasingly important role.

Reference£º
Patent; VITAE PHARMACEUTICALS, INC.; CLAREMON, David, A.; LEFTHERIS, Katerina; ZHUANG, Linghang; TICE, Colin, M.; SINGH, Suresh, B.; YE, Yuanjie; WO2011/11123; (2011); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare