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Optically active 2,6-bis<(S)-4'-benzyloxazolin-2'-yl>pyridine, pybox-(S,S)-bz (1), proved to make a well-matched base-acid pair with the (S)-enantiomer of 1,1′-bi-2-naphthol on the basis of 1H-NMR study.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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The resolution of the diastereoisomeric salts of the title compounds was possible in the presence of a ketone, especially acetone, which forms oxazolidines (3a-d) with the chiral bases.These oxazolidines afforded separable salts with the (S,R)-1,1′-Bi-2,2′-naphthylhydrogenphosphate (4).The structures of these salts were proved by m.s. and n.m.r. spectroscopy.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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The present invention discloses substituted diaryl quinoline derivatives I represented by Formula, and salts. thereof with a pharmaceutically acceptable acid or base for use in the treatment of mycobacterium tuberculosis diseases, particularly pathogenic mycobacteria, such as Mycobacterium tuberculosis, M. tuberculosis, of the present invention as defined below, The compounds of the. present invention are defined as follows :R. 1 Phenyl and naphthyl group, 3 – containing cyclopropyl and cyclopropyl derivatives ;R hydroxypropylene or propyne – 1 1-yl2 Is Br;R. 1 Is phenyl and substituted phenyl, naphthalene – 1 1-base, R2 Is, 3 – hydroxypropylene or propyne – 1 1-yl and the like; containing cyclopropyl and cyclopropyl derivatives. . (by machine translation)

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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An efficient Rh(II) carboxylate and Bronsted acid catalyzed direct pi-extension of indoles to 4-substituted carbazoles is developed. The reaction involves a regioselective C-3 functionalization of indole by a rhodium enalcarbenoid and a Bronsted acid assisted cyclocondensation. In addition a twofold regioselective pi-extension of pyrroles to 4,8-disubstituted carbazoles has also been developed. The utility of the methodology was demonstrated with the synthesis of analogues of an hepatitis C virus replication inhibitor and a secreted phospholipase A2 (sPLA2) inhibitor.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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2-Methallyl aromatic aldehydes, synthesized by Suzuki coupling of 2-formylphenylboronic acids, are shown to provide cycloalkylidene ene products under acidic conditions. Susceptibility of the products to aromatization is manoeuvred by varying the reaction conditions and catalysts including binol-derived Br°nsted acid catalysts. A peri-effect is identified as a controlling factor for the aromatizations. Several oxidative transformations of an ene product are carried out as model studies of hydroaromatic polyketide natural products.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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Herein, we present the Br°nsted-acid-controlled, primary-amine-catalyzed stereoselective asymmetric synthesis of druglike six-membered spirooxindoles from simple aliphatic substrates through a Barbas [4+2]-cycloaddition reaction by using 2-aminobuta-1,3-diene catalysis under ambient conditions.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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A highly efficient synthesis of spiro-tetrahydroquinolines (up to 99% yield) has been realized via cascade hydrogenative dearomatization of quinoline and intramolecular aza-Friedel-Crafts alkylation reaction.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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An unprecedented cascade beta-functionalization/aromatization reaction of N-arylpyrrolidines was established. A series of beta-substituted arylpyrroles embedded with trifluoromethyl groups are provided directly from N-arylpyrrolidines. The deuterium-labeling experiments indicate that sequential double hydride transfer processes serve as the key steps in this transformation.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 39648-67-4, C20H13O4P. A document type is Article, introducing its new discovery., category: chiral-catalyst

We report that R and S quenchers <(R)-(+)- and (S)-(-)-N,N-dimethyl-1-phenethylamine,RQ and SQ> recognize differently an R exciced-state chiral surface (silica derivatized with (R)-(-)-1,1-binaphthyl-2,2′-dihydrogen phosphate, RS).This is revealed by a ca. 30percent difference in Stern-Volmer constans between RQ/RS and SQ/RS.A similar recognition difference was obtained between these quenchers and the corresponding S-(+) surface.The surface derivatization enhances the chiral recognition; in solution, no difference between the constans was observed.It is suggested that what we believe to be the first observation of a photophysical recognition of a chiral surface can be explained in terms of an increase in the relative weight of an exciplex formation (over ion-pair formation) quenching route and and in terms of the decrease in the dimensionality of the quenching process.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 39648-67-4, Name is (R)-4-Hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide, molecular formula is C20H13O4P. In a Article,once mentioned of 39648-67-4, Safety of (R)-4-Hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine 4-oxide

A Rh(II)/chiral phosphoric acid cocatalyzed four-component reaction of indoles, 3-diazooxindoles, arylamines, and ethyl glyoxylate is developed, offering an extremely efficient strategy for the construction of 3,3-disubstituted 3-indol-3?-yloxindoles with excellent diastereoselectivities and high to excellent enantioselectivities. This transformation is proposed to proceed through a Mannich-type trapping of the zwitterionic intermediate generated from a metal carbene and an indole with an iminoester derived from an arylamine and a glyoxylate.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare