Category: 39856-52-5

Reference of N5,N5-Dimethylpyridine-2,5-diamine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: N5,N5-Dimethylpyridine-2,5-diamine, is researched, Molecular C7H11N3, CAS is 39856-52-5, about Structure-Activity Relationship of Imidazo[1,2-a]pyridines as Ligands for Detecting β-Amyloid Plaques in the Brain. Author is Zhuang, Zhi-Ping; Kung, Mei-Ping; Wilson, Alan; Lee, Chi-Wan; Ploessl, Karl; Hou, Catherine; Holtzman, David M.; Kung, Hank F..

A series of novel β-amyloid (Aβ) aggregate-specific ligands, e.g., 2-(4′-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine (I; IMPY), and its related derivatives were prepared An in vitro binding study with preformed Aβ aggregates showed that I and its bromo derivative competed with binding of 2-(4′-dimethylaminophenyl)-6-iodobenzothiazole, [125I]7(TZDM), a known ligand for Aβ aggregates, with high binding affinities (Ki = 15 and 10 nM, resp.). In vitro autoradiog. of brain sections of a transgenic mouse (Tg2576) with [125I]-I displayed high selective binding to amyloid-like structures, comparable to that observed by staining with thioflavin-S visualized under fluorescence. In vivo biodistribution after an i.v. injection of [125I]-I in normal mice showed a high initial brain uptake and fast washout, indicating a low background activity associated with this iodinated ligand. Taken together, the data suggests that [123I]-I may be useful for imaging Aβ aggregates in patients with Alzheimer’s disease.

This compound(N5,N5-Dimethylpyridine-2,5-diamine)Reference of N5,N5-Dimethylpyridine-2,5-diamine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Ple, Patrick A.; Jung, Frederic; Ashton, Sue; Hennequin, Laurent; Laine, Romuald; Morgentin, Remy; Pasquet, Georges; Taylor, Sian published an article about the compound: N5,N5-Dimethylpyridine-2,5-diamine( cas:39856-52-5,SMILESS:NC1=NC=C(N(C)C)C=C1 ).Recommanded Product: N5,N5-Dimethylpyridine-2,5-diamine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:39856-52-5) through the article.

A new series of quinazolinyloxy- and quinazolinylamonopyrazoleacetamides which inhibits VEGFR-2 and PDGFR tyrosine kinases is described here. In vitro, pharmacokinetics and in vivo evaluations led to the selection of AZD2932 (I).

Different reactions of this compound(N5,N5-Dimethylpyridine-2,5-diamine)Recommanded Product: N5,N5-Dimethylpyridine-2,5-diamine require different conditions, so the reaction conditions are very important.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase, published in 2011, which mentions a compound: 39856-52-5, mainly applied to imidazo pyridine derivative preparation structure IGF1R tyrosine kinase antitumor, Safety of N5,N5-Dimethylpyridine-2,5-diamine.

We disclose a novel series of insulin-like growth factor-1 receptor kinase inhibitors based on the 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridine scaffold. The influence on the inhibitory activity of substitution on the imidazopyridine and at the C5 position of the pyrimidine is discussed. In the course of this optimization, we discovered a potent and selective inhibitor with suitable pharmacokinetics for oral administration.

After consulting a lot of data, we found that this compound(39856-52-5)Safety of N5,N5-Dimethylpyridine-2,5-diamine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: N5,N5-Dimethylpyridine-2,5-diamine( cas:39856-52-5 ) is researched.SDS of cas: 39856-52-5.Zhao, Hui; Hu, Xiaoxia; Cao, Kai; Zhang, Yue; Zhao, Kuantao; Tang, Chunlei; Feng, Bainian published the article 《Synthesis and SAR of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as potent and selective CDK4/6 inhibitors》 about this compound( cas:39856-52-5 ) in European Journal of Medicinal Chemistry. Keywords: pyrazoloquinazoline arylamino carboxamide preparation antitumor cyclin dependent kinase inhibitor; Anticancer; Cell cycle; Cyclin dependent kinase; Kinase selectivity. Let’s learn more about this compound (cas:39856-52-5).

CDK4/6 pathway is an attractive target for development of anti-cancer drugs. Herein, design and synthesis of a series of I (R1 = Ph; R2, R3 = H, Me; R4 = OEt, NH2, NHMe, NHEt) and I [R1 = 3-Me2NC6H4, 4-(piperazin-1-yl)phenyl, 2-pyridyl, etc.; R2 = R3 = H; R4 = NH2] as selective CDK4/6 inhibitors is reported. Applied with the optimizing strategy to the initial scaffold, it is found that the compound I [R1 = 5-(4-methylpiperazin-1-yl)pyridin-2-yl; R2 = R3 = H; R4 = NH2] is able to selectively inhibit CDK4 and CDK6 with IC50 values 0.01 and 0.026 μM, resp. This compound showed good anti-proliferative activity when tested in a panel of tumor cell lines with CDK4/6 related mechanism of action and worked much better than Ly2385219 which is a selective CDK4/6 inhibitor. This compound was also found to have favorable pharmacokinetic parameters.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: N5,N5-Dimethylpyridine-2,5-diamine, is researched, Molecular C7H11N3, CAS is 39856-52-5, about Substituent effects on the amino-group chemical shifts in NMR spectra of substituted aminopyridines.Related Products of 39856-52-5.

Correlation analyses are presented for amino-group proton chem. shifts in m- and p-substituted (with respect to the amino group) 2-, 3-, and 4-aminopyridines (6 series altogether) using inductive and resonant substituent constants

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare