Category: 43142-76-3

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate(SMILESS: O=C(C(N1)=C(C=O)C2=C1C=CC(Cl)=C2)OCC,cas:43142-76-3) is researched.Category: chiral-catalyst. The article 《Synthesis and antituberculosis activity of indole-pyridine derived hydrazides, hydrazide-hydrazones, and thiosemicarbazones》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:43142-76-3).

We describe the design, synthesis, and in vitro antimycobacterial activity of a series of novel simple hybrid hydrazides and hydrazide-hydrazones combining indole and pyridine nuclei. The compounds are derivatives of 1-acetylindoxyl or substituted indole-3-carboxaldehydes tethered via a hydrazine group by simple C-N or double C:N bonds with 3- and 4-pyridines, 1-oxide 3- and 4-pyridine carbohydrazides. The most active of the 15 compounds showed MICs values against an INH-sensitive strain of Mycobacterium tuberculosis H37Rv equal to that of INH (0.05-2 μg/mL). Five compounds demonstrated appreciable activity against the INH-resistant M. tuberculosis CN-40 clin. isolate (MICs: 2-5 μg/mL), providing justification for further in vivo studies.

This compound(Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate)Application In Synthesis of Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 43142-76-3, is researched, Molecular C12H10ClNO3, about Fischer indolization and its related compounds. V. Indolization of ethyl pyruvate 2-methoxyphenylhydrazone and its N-methyl derivative with protic acids. Unpredictable products and the mechanism, the main research direction is Fischer indole synthesis mechanism; indolization pyruvate methoxyphenylhydrazone mechanism.Application In Synthesis of Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate.

Fischer indolization of Et pyruvate 2-methoxyphenylhydrazone (I) and its N-Me derivative with protic acids gives mainly 6-substituted indole derivatives formed by substitution of the MeO group of I with nucleophiles in the reaction medium. The mechanism involved the cation II as the key intermediate in the formation of the unexpected indole products.

《Fischer indolization and its related compounds. V. Indolization of ethyl pyruvate 2-methoxyphenylhydrazone and its N-methyl derivative with protic acids. Unpredictable products and the mechanism》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate)Application In Synthesis of Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate.

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Recommanded Product: 43142-76-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, is researched, Molecular C12H10ClNO3, CAS is 43142-76-3, about Synthesis and properties of certain 5H-pyridazino[4,5-b]indoles. Author is El-Gendy, A.A.; Abou-Sier, Afaf H..

5H-Pyridazino[4,5-b]indoles [I; R = H, Me, benzyl] were obtained by heating Et 3-formylindole-2-carboxylates [II; R same as above; R1 = CHO, R2 = OEt] with hydrazine hydrate or by direct formylation of the corresponding 2-indolecarboxhydrazides II [R same as above; R1 = H, R2 = NHNH2] with dimethylformamide/phosphoryl chloride. The 4-chloro-5H-pyridazino[4,5-b]indoles [III; R same as above; R3 = Cl] were prepared by treatment of I with phosphoryl chloride. Reaction of compounds III [R same as above; R3 = Cl] with hydrazine hydrate yielded the 4-hydrazino-5H-pyridazino[4,5-b]indoles [III; R same as above; R3 = NHNH2]. The antihypertensive activity of compound [III; R = H, R3 = NHNH2] is under pharmacol. screening.

Different reactions of this compound(Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate)Recommanded Product: 43142-76-3 require different conditions, so the reaction conditions are very important.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, is researched, Molecular C12H10ClNO3, CAS is 43142-76-3, about Synthesis of 11H-1,2,4-triazolo[4,3-b]pyridazino[4,5-b]indoles.Computed Properties of C12H10ClNO3.

4-Oxo-5H-pyridazino[4,5-b]indoles, obtained from the corresponding 3-formylindole-2-carboxylates, were subjected to chlorination to obtain the corresponding 4-chloro-5H-pyridazino[4,5-b]indoles which on reaction with hydrazine hydrate in the presence of K2CO3 give 4-hydrazino-5H-pyridazino[4,5-b]indole. The latter were treated with acetic acid/benzoyl chloride to yield the desired title compounds I (R = Me, OMe, Br, OEt, Cl; R1 = Me, Ph). These compounds were screened for their antimicrobial activity.

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Related Products of 43142-76-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, is researched, Molecular C12H10ClNO3, CAS is 43142-76-3, about Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity. Author is Mohamed, Fatma A. M.; Gomaa, Hesham A. M.; Hendawy, O. M.; Ali, Asmaa T.; Farghaly, Hatem S.; Gouda, Ahmed M.; Abdelazeem, Ahmed H.; Abdelrahman, Mostafa H.; Trembleau, Laurent; Youssif, Bahaa G. M..

New EGFR inhibitor series of fifteen 5-chloro-3-hydroxymethyl-indole-2-carboxamide derivatives I (R1, R2 = H, Me; R3 = Me2N, pyrrolidin-1-yl, piperidin-1-yl, etc., R4 = H; R3 = H, R4 = pyrrolidin-1-yl, morpholin-4-yl, etc.) and II [R5 = 1-benzylpiperidin-3-yl, 1-benzylpyrrolidin-3-yl, 2-(morpholin-4-yl)ethyl] has been designed, synthesized, and tested for antiproliferative activity against a panel of cancer cell lines. The results showed that p-substituted phenethyl derivatives showed superior antiproliferative activity compared to their m-substituted counterparts. Compounds I (R1 = R2 = R4 = H; R3 = piperidin-1-yl, morpholin-4-yl) and I (R1 = R2 = R3 = H; R4 = piperidin-1-yl, morpholin-4-yl) displayed promising EGFR inhibitory activity as well as an increase in caspase 3 levels. Compounds I (R1 = R2 = R4 = H; R3 = piperidin-1-yl, 4-morpholin-4-yl) increased caspase-8 and 9 levels, as well as inducing Bax and decreasing Bcl-2 protein levels. The compound I (R1 = R2 = R4 = H; R3 = morpholin-4-yl) demonstrated cell cycle arrest at pre-G1 and G2/M phases. The results of the docking study into the active site of EGFR revealed strong fitting of the new compounds with higher binding affinities compared to erlotinib.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Moll, Annette; Hubner, Harald; Gmeiner, Peter; Troschutz, Reinhard researched the compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate( cas:43142-76-3 ).Recommanded Product: 43142-76-3.They published the article 《Phenylpiperazinylmethylindolecarboxylates and derivatives as selective D4-Ligands》 about this compound( cas:43142-76-3 ) in Bioorganic & Medicinal Chemistry. Keywords: phenylpiperazinylmethylindolecarboxylate derivative preparation structure activity dopamine D4 receptor binding. We’ll tell you more about this compound (cas:43142-76-3).

Novel phenylpiperazinylmethylindolecarboxylates were synthesized for evaluation as potential D4-ligands. Test compounds showed high affinity for the human dopamine D4 receptor and great selectivity over the other receptor subtypes. Intrinsic effects of indole derivatives, which indicated most promising binding properties, were investigated in a mitogenesis assay.

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Category: chiral-catalyst. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, is researched, Molecular C12H10ClNO3, CAS is 43142-76-3, about Design of C3-Alkenyl-Substituted 2-Indolylmethanols for Catalytic Asymmetric Interrupted Nazarov-Type Cyclization.

The C3-alkenyl-substituted 2-indolylmethanols were designed as a new class of substrates for catalytic asym. interrupted Nazarov-type cyclizations. In the presence of a chiral phosphoric acid as a mild chiral Bronsted acid, the interrupted Nazarov-type cyclization of C3-alkenyl-substituted 2-indolylmethanols I (R1 = Ph, 4-ClC6H4, 2-FC6H4, etc.; R2 = Ph, 3-FC6H4, 3-MeC6H4; R3 = H, Cl, Br, MeO) with nucleophiles R4H (R4 = 3-indolyl, 2-hydroxy-1-naphthyl, etc.) occurred smoothly to construct cyclopenta[b]indole frameworks II with generally excellent diastereo- and enantioselectivities (up to >95:5 dr, >99% ee).

Here is just a brief introduction to this compound(43142-76-3)Category: chiral-catalyst, more information about the compound(Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate) is in the article, you can click the link below.

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Chiral Catalysts,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, is researched, Molecular C12H10ClNO3, CAS is 43142-76-3, about Synthesis of some diazocino, diazepino and pyridazinoindoles.Computed Properties of C12H10ClNO3.

The trials and method used for the synthesis of diazocino[6,7-b]indoles (I, R, R1 = H, Me; X = H, Cl) by reacting aldehydic indole esters with o-phenylenediamines are described. [1,2]Diazepino[4,5-b]indoles (II, R = H, Me) were obtained from hydrazinolysis of the oxopropyl derivatives which were in turn produced by reductive hydrolysis of nitrovinylindoles. Pyridazino[4,5-b]indoles (III, R = H, Me), were prepared either via hydrazinolysis of 3-cyano-2-ethoxy-carbonylindoles to produce the intermediates 3-cyano-2-hydrazinocarbonylindoles followed by cyclization, or directly by heating 3-cyano-2-ethoxy-carbonylindoles with hydrazine. Condensation of the indole carboxyaldehyde with some aromatic amines yielded the Schiff bases.

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Recommanded Product: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, is researched, Molecular C12H10ClNO3, CAS is 43142-76-3, about Synthesis of substituted 3-amino-4-cyano-1-oxo-1,2,5,10-tetrahydroazepino[3,4-b]indoles. Author is Troschutz, Reinhard; Hoffmann, Armin.

The preparation of 3-amino- and 3-(dialkylamino)-4-cyanoazepino[3,4-b]indoles bearing substituents on the aromatic nucleus and N-10 is outlined. Starting from suitably substituted Et 3-formylindole-2-carboxylates, condensation with malononitrile and subsequent sodium borohydride reduction yielded Et 3-(2,2-dicyanoethyl)indole-2-carboxylates, resp., which were cyclized in boiling alkoxides to 3-alkoxy-4-cyanoazepino[3,4-b]indoles, e.g., I (R = OMe). This sequence constitutes a novel and flexible route to functional azepino[3,4-b]indoles. Aminolysis of the alkoxy derivatives yielded the title compounds, e.g., I (R = NMe2), which exhibited little or no biol. activity in several tests.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Qiao, Chang-Jiang; Ali, Hamed I.; Ahn, Kwang H.; Kolluru, Srikanth; Kendall, Debra A.; Lu, Dai researched the compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate( cas:43142-76-3 ).Application of 43142-76-3.They published the article 《Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor》 about this compound( cas:43142-76-3 ) in European Journal of Medicinal Chemistry. Keywords: indole carboxamide preparation allosteric modulator; Allosteric modulator; Cannabinoid receptor; Photoactivatable ligands; Photoaffinity labeling. We’ll tell you more about this compound (cas:43142-76-3).

The compound 5-chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide (ORG27569) is a prototypical allosteric modulator for the cannabinoid CB1 receptor. Based on this indole-2-carboxamide scaffold, a novel CB1 allosteric modulators that possess photoactivatable functionalities I (R = N3, N(CH3)2, piperidin-1-yl, etc.; R1 = N3CH2, C2H5, C5H11, etc.) has been designed and synthesized. To assess their allosteric effects, the dissociation constant (KB) and allosteric binding cooperativity factor (α) are determined and compared to their parent compds I (R = piperidin-1-yl, N(CH3)2; R1 = C2H5, n-C5H11, n-C6H13). With in this series, benzophenone-containing compounds I (R = (CO)C6H5; R1 = C2H5, n-C5H11, CH2N3), phenylazide-containing compound I (R = N3; R1 = n-C6H13), and the aliphatic azide containing compound I showed allosteric binding parameters (KB and α) comparable to their parent compound I (R = piperidin-1-yl, N(CH3)2; R1 = C2H5, n-C5H11, n-C6H13), resp. These modulators for their impact on G-protein coupling activity has been further assessed. Interestingly, these compounds exhibited neg. allosteric modulator properties in a manner similar to their parent compounds I, which antagonize agonist-induced G-protein coupling. These novel CB1 allosteric modulators, possessing photoactivatable functionalities, provide valuable tools for future photo-affinity labeling and mapping the CB1 allosteric binding site(s).

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