Category: 43142-76-3

Formula: C12H10ClNO3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, is researched, Molecular C12H10ClNO3, CAS is 43142-76-3, about Synthesis and biological activity of functionalized indole-2-carboxylates, triazino- and pyridazino-indoles. Author is El-Gendy, Adel A.; Said, Mohamed M.; Ghareb, Nagat; Mostafa, Yasser M.; El-Ashry, El Sayed H..

Condensation of aryl hydrazines with Et pyruvate gave the resp. hydrazones; Fischer indolization led to substituted-1H-indole-2-carboxylic acid Et esters. The Mannich reaction of these compounds with formaldehyde and morpholine yielded Et 3-(morpholino-methyl)-substituted-1H-indole-2-carboxylates. The 5,7-dichloro-1H-indole-2-carbohydrazide was cyclized with Me orthoformate in DMF to give 6,8-dichloro[1,2,4]triazino[4,5-a]indol-1(2H)-one. Vilsmeier-Haack formylation of substituted-1H-indole-2-carboxylates gave Et 3-formyl-substituted-1H-indole-2-carboxylates whose 2,2′-((5-chloro-2-(ethoxycarbonyl)-1H-indol-3-yl)methylene)bis-(sulfanediyl) diacetic acid was also prepared The reaction of 3-formyl-substituted-1H-indole-2-carboxylates with substituted anilines by conventional and microwave methods gave Et 3-(N-aryliminomethyl)-5-halo-1H-indole-2-carboxylates. In a cyclocondensation reaction of these compounds with thiolactic acid or thioglycolic acid substituted indolylthiazolidinones were prepared Reaction of hydrazine hydrate with 3-formyl-substituted-1H-indole-2-carboxylates did not give the resp. hydrazones but directly led to the cyclized products substituted-3H-pyridazino[4,5-b]indol-4(5H)-ones, while a reaction with 2,4-dichlorophenylhydrazine yielded the uncyclized hydrazones. The chlorination of pyridazino[4,5-b]indol-4(5H)-one derivatives with POCI3 gave pyridazino[4,5-b]indoles, resp.; reaction of the latter compounds with morpholine gave 4-(substituted-5H-pyridazino[4,5-b]indol-4-yl)morpholines. Mannich reaction of pyridazino[4,5-b]indol-4(5H)-one with formaldehyde and N-ethylpiperazine gave 8-chloro-3-((4-ethylpiperazin-1-yl)methyl)-3H-pyridazino[4,5-b]indol-4(5H)-one. The microwave assistance of selected reactions has a profound effect on the reaction speed. The structures of the new compounds were confirmed by both anal. and spectral data. Some compounds were subjected to investigations concerning their antimicrobial, tranquilizing, and anticonvulsant activities.

There is still a lot of research devoted to this compound(SMILES：O=C(C(N1)=C(C=O)C2=C1C=CC(Cl)=C2)OCC)Formula: C12H10ClNO3, and with the development of science, more effects of this compound(43142-76-3) can be discovered.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

HPLC of Formula: 43142-76-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, is researched, Molecular C12H10ClNO3, CAS is 43142-76-3, about Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid CB1 Receptor. Author is Piscitelli, Francesco; Ligresti, Alessia; La Regina, Giuseppe; Coluccia, Antonio; Morera, Ludovica; Allara, Marco; Novellino, Ettore; Di Marzo, Vincenzo; Silvestri, Romano.

New N-phenylethyl-1H-indole-2-carboxamides as the first SAR study of allosteric modulators of the CB1 receptor were synthesized. The presence of the carboxamide functionality was required in order to obtain a stimulatory effect. The maximum stimulatory activity on CB1 was EC50 = 50 nM.

There is still a lot of research devoted to this compound(SMILES：O=C(C(N1)=C(C=O)C2=C1C=CC(Cl)=C2)OCC)HPLC of Formula: 43142-76-3, and with the development of science, more effects of this compound(43142-76-3) can be discovered.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 43142-76-3, is researched, SMILESS is O=C(C(N1)=C(C=O)C2=C1C=CC(Cl)=C2)OCC, Molecular C12H10ClNO3Journal, Article, Bioorganic & Medicinal Chemistry called Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: Exploration of 5-6 fused rings as alternative S1 moieties, Author is Yoshikawa, Kenji; Yokomizo, Aki; Naito, Hiroyuki; Haginoya, Noriyasu; Kobayashi, Shozo; Yoshino, Toshiharu; Nagata, Tsutomu; Mochizuki, Akiyoshi; Osanai, Ken; Watanabe, Kengo; Kanno, Hideyuki; Ohta, Toshiharu, the main research direction is cis diamino cyclohexane derivative factor Xa inhibitor structure.Synthetic Route of C12H10ClNO3.

A series of cis-1,2-diaminocyclohexane derivatives were synthesized with the aim of optimizing previously disclosed factor Xa (fXa) inhibitors. The exploration of 5-6 fused rings as alternative S1 moieties resulted in two compounds which demonstrated improved solubility and reduced food effect compared to the clin. candidate, compound A. Herein, we describe the synthesis and structure-activity relationship (SAR), together with the physicochem. properties and pharmacokinetic (PK) profiles of some prospective compounds

If you want to learn more about this compound(Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate)Synthetic Route of C12H10ClNO3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(43142-76-3).

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 43142-76-3, is researched, SMILESS is O=C(C(N1)=C(C=O)C2=C1C=CC(Cl)=C2)OCC, Molecular C12H10ClNO3Journal, Organic Chemistry Frontiers called Catalytic enantioselective and regioselective substitution of 2,3-indolyldimethanols with enaminones, Author is Lu, Yi-Nan; Ma, Chun; Lan, Jin-Ping; Zhu, Caiqiang; Mao, Yu-Jia; Mei, Guang-Jian; Zhang, Shu; Shi, Feng, the main research direction is indolylmethylcyclohexenone enantioselective regioselective preparation antitumor activity; indolyl dimethanol cyclic enaminone BINOL catalyst substitution reaction.Reference of Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate.

2,3-Indolyldimethanols as a new class of indolyldimethanols were designed, and the first catalytic asym. substitution of 2,3-indolyldimethanols were established by using cyclic enaminones as nucleophiles, which afforded substitutive products in an enantioselective and regioselective mode (up to 98% ee, all >95 : 5 rr). This reaction represented the first design and application of 2,3-indolyldimethanols in catalytic asym. reactions, which greatly enriched the chem. of indolyldimethanols.

Here is a brief introduction to this compound(43142-76-3)Reference of Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, if you want to know about other compounds related to this compound(43142-76-3), you can read my other articles.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare