Category: 7181-87-5

Electric Literature of 7181-87-5, An article , which mentions 7181-87-5, molecular formula is C9H11IN2. The compound – 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide played an important role in people’s production and life.

Bis (benzimidazole -2 – ylidene) compound having a crosslinking structure of the alkyl chain, an organic light emitting element having the same, display device, an information processing device, illumination device, Image forming apparatus, the exposure device (by machine translation)

[Problem] bis (benzimidazole -2 – ylidene) high stability against oxidation of alkyl-linked compound. [Solution] formula 1: bis (benzimidazole -2 – ylidene) compound represented. [Ar1 And Ar2 Are each independently an aromatic hydrocarbon group or a heterocyclic aromatic ring group; R1 – R8 Are each independently H, halogen, cyano, alkyl, aryl or; Q1 – Q6 Are each independently H, halogen or alkyl; n is an integer of 0 – 2; n is 0 when, single bond][Drawing] no (by machine translation)

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Reference of 7181-87-5, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.7181-87-5, Name is 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide, molecular formula is C9H11IN2. In a patent, introducing its new discovery.

Method for preparing metallic carbene-based catalysts for hydrosilylation of unsaturated compounds and resulting catalysts

The invention concerns an improved method for preparing catalysts for hydrosilylation reactions of compounds with ethylene or acetylene unsaturation (for example olefins or acetylene derivatives), in particular but not exclusively those involving polyorganosiloxanes (POS) bearing Si?H units and POS bearing Si-(ethylene or acetylene unsaturation) units. Said preparation corresponds to the following synthesis (I), wherein: A=B=carbon: T1, T2=cyclohexyl, t-butyl or methyl; T3, T4=H; DVTMS=divinyltetramethylsiloxane; t-BuOK=potassium tert-butylate; T.A=room temperature. The invention is characterised in that it consists in carrying out said synthesis in a single step by bringing together salt (III) above, Karstedt (IV) in the presence of a solvent (V) (THF) and a base (VI) (t-BuOK) at room temperature. 1

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 7181-87-5, Name is 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide, Quality Control of: 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide.

Potent Inhibition of Thioredoxin Reductase by the Rh Derivatives of Anticancer M(arene/Cp*)(NHC)Cl2 Complexes

Metal complexes provide a versatile platform to develop novel anticancer pharmacophores, and they form stable compounds with N-heterocyclic carbene (NHC) ligands, some of which have been shown to inhibit the cancer-related selenoenzyme thioredoxin reductase (TrxR). To expand a library of isostructural NHC complexes, we report here the preparation of RhIII- and IrIII(Cp*)(NHC)Cl2 (Cp? = eta5-pentamethylcyclopentadienyl) compounds and comparison of their properties to the RuII- and OsII(cym) analogues (cym = eta6-p-cymene). Like the RuII- and OsII(cym) complexes, the RhIII- and IrIII(Cp*) derivatives exhibit cytotoxic activity with half maximal inhibitory concentration (IC50) values in the low micromolar range against a set of four human cancer cell lines. In studies on the uptake and localization of the compounds in cancer cells by X-ray fluorescence microscopy, the Ru and Os derivatives were shown to accumulate in the cytoplasmic region of treated cells. In an attempt to tie the localization of the compounds to the inhibition of the tentative target TrxR, it was surprisingly found that only the Rh complexes showed significant inhibitory activity at IC50 values of ?1 muM, independent of the substituents on the NHC ligand. This indicates that, although TrxR may be a potential target for anticancer metal complexes, it is unlikely the main target or the sole target for the Ru, Os, and Ir compounds described here, and other targets should be considered. In contrast, Rh(Cp*)(NHC)Cl2 complexes may be a scaffold for the development of TrxR inhibitors.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide. In my other articles, you can also check out more blogs about 7181-87-5

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.7181-87-5, Name is 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide, molecular formula is C9H11IN2. In a Article£¬once mentioned of 7181-87-5, COA of Formula: C9H11IN2

A chemical-biological evaluation of rhodium(I) n-heterocyclic carbene complexes as prospective anticancer drugs

Rhodium(I) complexes bearing N-heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry, but there are very few reports of biological properties of these organometallics. A series of RhI-NHC derivatives with 1,5-cyclooctadiene and CO as secondary ligands were synthesized, characterized, and biologically investigated as prospective antitumor drug candidates. Pronounced antiproliferative effects were noted for all complexes, along with moderate inhibitory activity of thioredoxin reductase (TrxR) and efficient binding to biomolecules (DNA, albumin). Biodistribution studies showed that the presence of albumin lowered the cellular uptake and confirmed the transport of rhodium into the nuclei. Changes in the mitochondrial membrane potential (MMP) were observed as well as DNA fragmentation in wild-type and daunorubicin- or vincristine-resistant Nalm-6 leukemia cells. Overall, these studies indicated that RhI-NHC fragments could be used as partial structures of new antitumor agents, in particular in those drugs designed to address resistant malignant tissues. No resistance to special agents: Rhodium(I) N-heterocyclic carbene (NHC) derivatives with 1,5-cyclooctadiene (COD) and CO as secondary ligands were synthesized, characterized, and biologically investigated as prospective antitumor drug candidates. Pronounced antiproliferative effects were noted for all complexes, along with efficient binding to biomolecules. RhI-NHC fragments could be used as partial structures of new antitumor agents, particularly in drugs designed to address daunorubicin- (DNR) and vincristine (VCR)-resistant malignant tissues (see figure). Copyright

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 7181-87-5, Name is 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide, molecular formula is C9H11IN2. In a Article£¬once mentioned of 7181-87-5, Formula: C9H11IN2

Synthesis and antimicrobial activity of substituted benzimidazole, benzothiazole and imidazole derivatives

New benzimidazole, benzothiazole and imidazole derivatives were synthesized by reacting electron-rich olefins (5, 23 and 29) with appropriate reagents. The compounds synthesized were identified by 1H, 13C-NMR, FT-IR and mass spectroscopic techniques and micro analysis. All new and related compounds were evaluated for their in vitro antimicrobial activity against different bacteria. The compounds 17, 18, 19, 20, 21, 22 and 24 were found very effective to inhibit the growth of Enterococcus faecalis (ATCC 29212) and Staphylococcus aureus (ATCC 29213) at minimum inhibitory concentrations (MICs) of 25, 25, 12.5, 50, 25, 50 and 50 mug/ml, respectively. The compounds 4, 10a, 10c, 16, 25, 26 and 31 were significantly effective against Enterococcus faecalis (ATCC 29212) and Staphylococcus aureus (ATCC 29213) with MIC values of 100-200 mug/ml. None of the compounds proved to be effective against Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853) in the concentrations studied.

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 7181-87-5, Name is 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide, molecular formula is C9H11IN2. In a Article£¬once mentioned of 7181-87-5, name: 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide

A New Mode of Operation of Pd-NHC Systems Studied in a Catalytic Mizoroki-Heck Reaction

Metal complexes bearing N-heterocyclic carbene (NHC) ligands are typically considered the system of choice for homogeneous catalysis with well-defined molecular active species due to their stable metal-ligand framework. A detailed study involving 19 different Pd-NHC complexes with imidazolium, benzimidazolium, and triazolium ligands has been carried out in the present work and revealed a new mode of operation of metal-NHC systems. The catalytic activity of the studied Pd-NHC systems is predominantly determined by the cleavage of the metal-NHC bond, while the catalyst performance is strongly affected by the stabilization of in situ formed metal clusters. In the present study, the formation of Pd nanoparticles was observed from a broad range of metal complexes with NHC ligands under standard Mizoroki-Heck reaction conditions. A mechanistic analysis revealed two different pathways to connect Pd-NHC complexes to “cocktail”-type catalysis: (i) reductive elimination from a Pd(II) intermediate and the release of NHC-containing byproducts and (ii) dissociation of NHC ligands from Pd intermediates. Metal-NHC systems are ubiquitously applied in modern organic synthesis and catalysis, while the new mode of operation revealed in the present study guides catalyst design and opens a variety of novel opportunities. As shown by experimental studies and theoretical calculations, metal clusters and nanoparticles can be readily formed from M-NHC complexes after formation of new M-C or M-H bonds followed by C-NHC or H-NHC coupling. Thus, a combination of a classical molecular mode of operation and a novel cocktail-type mode of operation, described in the present study, may be anticipated as an intrinsic feature of M-NHC catalytic systems.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.name: 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 7181-87-5, in my other articles.

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7181-87-5. Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 7181-87-5, Name is 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide,introducing its new discovery.

Sterically Hindered N-Heterocyclic Salts Utilized as Antimicrobial Agents

By the adoption of annulated ring systems for their steric bulkiness, a new series of symmetric N-heterocyclic imidazolium and perimidium salts were synthesized. Also, corresponding asymmetric ferrocenyl N-functionalized series were prepared as salts. All the reported salts were fully characterized. The reported X-ray structure of 4,5-diphenyl-1,3-dimethyl-1H-imidazol-3-ium iodide (2a) shows that it crystallized in the orthorhombic space group P212121. Low to moderate antimicrobial activities were observed with both sets of salts against important clinical isolates of Staphylococcus aureus, Bacillus subtilis, and Enterococcus faecalis and Escherichia coli, Pseudomonas aeruginosa, and Salmonella enterica. The results were benchmarked against meropenem. Both 1,3-propyl-1H-phenanthro[9,10-d]imidazol-3-ium iodide (3b) and 1-ferrocenyl-3-propyl-1H-perimidin-3-ium iodide (9b) showed high antimicrobial activities against all tested Gram-positive bacterial strains, with minimum inhibitory concentration values ranging from 8 to 4?mug/mL (meropenem?=?0.5?0.125?mug/mL), while all the salts showed little or no activity against Gram-negative bacterial strains. In general, the asymmetric ferrocenyl-containing salts exhibited higher activities than the symmetric ones.

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Name is 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 7181-87-5, its synthesis route is as follows.,7181-87-5

A 20 mL of freshly dried THF was added to a mixture of Me2-bimy¡¤HI (0.40 g, 1.46 mmol) and KOtBu (0.13 g, 1.17 mmol), and the mixture was stirred in an ice-water bath for 2 h. The resulting dark yellow solution was filtered and removed under vacuum. The residue was washed with n-hexane several times and then 1,3-dimethylbenzimidazol-2-ylidene (Me2-bimy) was obtained (0.10 g, 0.68 mmol). A 15 mL THF was added to a mixture of [TeFe3(CO)9{Cu(MeCN)}2] (0.26 g, 0.34 mmol) and Me2-bimy (0.10 g, 0.68 mmol) in an ice-water bath, which was stirred for 15 min. The resulting solution was filtered, and the solvent was removed under vacuum. The residue was washed with deionized water and n-hexane several times and then extracted with Et2O to give a purplish-brown solution which was recrystallized with Et2O/CH2Cl2 to give [TeFe3(CO)9{Cu(Me2-bimy)}2] (1) as a purplish-black solid (0.154 g, 0.159 mmol, 47% based on [TeFe3(CO)9{Cu(MeCN)}2]). IR (nuCO, CH2Cl2): 2033 (m), 1976 (vs), 1920 (m), 1875 (w) cm-1. 1H NMR (500 MHz, DMSO-d6, 300 K, ppm): delta 7.69 (dd, 4H, Ar-H), 7.43 (dd, 4H, Ar-H), 4.02 (s, 12H; CH3).

With the complex challenges of chemical substances, we look forward to future research findings about 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide

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Article; Shieh, Minghuey; Liu, Yu-Hsin; Li, Yu-Huei; Lin, Chien-Nan; Wang, Chih-Chin; Journal of Organometallic Chemistry; vol. 867; (2018); p. 161 – 169;,
Chiral Catalysts
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Name is 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 7181-87-5, its synthesis route is as follows.,7181-87-5

General procedure: General Method: To a 20 mL solution of 1.1 equivalents of nickelocene (41 mg, 0.22 mmol) in anhydrous THF, the respective imidazolium NHC precursor (0.2 mmol) was added as a solid. The resulting suspension was then refluxed for 4 h. The general method was modified for 4, 5 and 6. The reactions involving the formation of more electron-deficient 4 and 5 required 10 h at reflux with 2 equivalents of nickelocene (75 mg, 0.4 mmol). Synthesis of 6 was achieved after 16 h of reflux in the presence of 2.6 equivalents of nickelocene (98 mg, 0.52 mmol). The compounds were then purified by column chromatography. Details available in the Supporting information.

With the complex challenges of chemical substances, we look forward to future research findings about 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide

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Conference Paper; Luca, Oana R.; Thompson, Bennett A.; Takase, Michael K.; Crabtree, Robert H.; Journal of Organometallic Chemistry; vol. 730; (2013); p. 79 – 83;,
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1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide, cas is 7181-87-5, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,7181-87-5

(1) Weigh 0.2 mmol (54.8 mg) of 1,3-dimethylbenzimidazole oxime iodide, 0.1 mmol (40.6 mg) of 1,4-diiodobiphenyl (both feed ratios of 2:1) as a substrate, 2 mg of Group IB copper salt Cu(OAc)2¡¤H2O (10 mol% equivalent relative to 1,4-diiodobiphenyl) as a catalyst, 0.2 mmol (16.4 mg) of sodium acetate as an additive, put the substrate, catalyst, additive and mixing into the reaction kettle, An aprotic solvent N,N-dimethylformamide (1 ml) was added as a reaction solvent, and the mixture was reacted at 100 C for 10 hours. After completion of the reaction, dichloromethane (5 ml) was added, filtered, and then washed twice with water (5 ml) and ethanol (5 ml). The obtained yellow filter residue is a pure product biphenyl bridged bisbenzimidazole, the yield was 90%. The nuclear magnetic resonance spectrum is shown in Figure 2: (deuterated dimethyl sulfoxide as solvent, Bruker AMX-400 nuclear magnetic resonance instrument). 1H NMR (400 MHz, DMSO-d6): delta = 8.28 (d, J = 8.0 Hz, 4H), 8.18 (d, J = 4.8 Hz, 4H), 8.11(d, J = 7.6 Hz, 4H), 7.80 (d, J = 4.8 Hz, 4H), 3.98 (s, 12H).High resolution mass spectrometry (Waters-Q-TOF Premier detector). HRMS (ESI) : C30H28IN4+ ([M-I-]+) calc.: 571.1353, Found: 571.1398.

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Patent; Guilin University of Technology; Li Shiqing; Li Yongshu; Liang Xiajing; Liu Yunfeng; Chen Ziyuan; Pan Meiling; (6 pag.)CN109734670; (2019); A;,
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