Application In Synthesis of H-Leu-NH2.HCl. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about C-H functionalization of N-methylated amino acids and peptides as tool in natural product synthesis: Synthesis of Abyssenine A and Mucronine E.
N-Methylated amino acids and peptides with an 8-aminoquinoline (AQ) directing group can be subjected to stereoselective Pd-catalyzed β-functionalizations. The best results are obtained with aryl iodides, but alkyl and alkenyl side chains can also be introduced. The AQ protecting group can easily be removed, providing the free carboxylic acid, which can be used directly in peptide couplings. This protocol was used successfully as a key step in the synthesis of the cyclopeptide alkaloids abyssenine A and mucronine E.
《C-H functionalization of N-methylated amino acids and peptides as tool in natural product synthesis: Synthesis of Abyssenine A and Mucronine E》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(H-Leu-NH2.HCl)Application In Synthesis of H-Leu-NH2.HCl.