Synthetic Route of 14187-32-7. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 14187-32-7, Name is Dibenzo-18-crown-6. In a document type is Article, introducing its new discovery.
Antitumor potential of crown ethers: Structure-activity relationships, cell cycle disturbances, and cell death studies of a series of ionophores
The present paper demonstrates the antiproliferative ability and structure-activity relationships (SAR) of 14 crown and aza-crown ether analogues on five tumor-cell types. The most active compounds were di-tert- butyldicyclohexano-18-crown-6 (3), which exhibited cytotoxicity in the submicromolar range, and di-tert-butyldibenzo-18-crown-6 (5) (IC50 values of ?2 muM). Also, 3 and 5 induced marked influence on the cell cycle phase distribution-strong G1 arrest, followed by the induction of apoptosis. A computational SAR modeling effort offers insight into possible mechanisms of crown ether biological activity, presumably involving penetration into cell membranes, and points out structural features of molecules important for this activity. The results reveal that crown ethers possess marked tumor-cell growth inhibitory activity, the extent of which depends on the characteristics of the hydrophilic macrocylic cavity and the surrounding hydrophobic ring. Our work supports the hypothesis that crown ether compounds inhibit tumor-cell growth by disrupting potassium ion homeostasis, which in turn leads to cell cycle perturbations and apoptosis.
If you are interested in 14187-32-7, you can contact me at any time and look forward to more communication.Synthetic Route of 14187-32-7
Reference£º
Chiral Catalysts,
Chiral catalysts – SlideShare