Discovery of (1R,2S)-(−)-2-Amino-1,2-diphenylethanol

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Synthetic Route of 23190-16-1. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 23190-16-1, Name is (1R,2S)-(−)-2-Amino-1,2-diphenylethanol. In a document type is Article, introducing its new discovery.

A chiral nitrogen-containing calix[4]crown 2 bearing optically pure 1,2-diphenyl-1,2-oxyamino residue at lower rim showed excellent chiral recognition between enantiomers of mandelic acid. Using competitive 1H NMR titration the ratio of association constants of (S)- and (R)-mandelic acid with the chiral calix[4]crown was determined to be 102, that is 98% de, which is the best result obtained from artificial receptors for the chiral recognition of mandelic acid up to now.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare