A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 168960-19-8, Name is ((1S,4R)-4-Aminocyclopent-2-en-1-yl)methanol hydrochloride, molecular formula is C6H12ClNO. In an article, author is Sharma, Hayden A.,once mentioned of 168960-19-8, Recommanded Product: ((1S,4R)-4-Aminocyclopent-2-en-1-yl)methanol hydrochloride.
We report a strategy for effecting catalytic, enantio-selective carbocationic rearrangements through the intermediacy of alkyl iodanes as stereodefined carbocation equivalents. Asymmetric Wagner-Meerwein rearrangements of beta-substituted styrenes are catalyzed by the C-2-symmetric aryl iodide 1 to provide access to enantioenriched 1,3-difluorinated molecules possessing interesting and well-defined conformational properties. Hammett and kinetic isotope effect studies, in combination with computational investigations, reveal that two different mechanisms are operative in these rearrangement reactions, with the pathway depending on the identity of the migrating group. In reactions involving alkyl-group migration, intermolecular fluoride attack is product- and enantio-determining. In contrast, reactions in which aryl rearrangement occurs proceed through an enantiodetermining intramolecular 1,2-migration prior to fluorination. The fact that both pathways are promoted by the same chiral aryl iodide catalyst with high enantioselectivity provides a compelling illustration of generality across reaction mechanisms in asymmetric catalysis.
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Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare