22795-99-9, (S)-(1-Ethylpyrrolidin-2-yl)methanamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
22795-99-9, First, 4-benzyloxy-3,5-dimethoxybenzoic acid chloride represented by Formula 85 and [(2S)-1-ethylpyrrolidin-2-yl]methanamine represented by Formula 103 were prepared in 0.2 M solution, respectively, using a toluene solvent. An amine solution (1.2 mL, 0.240 mmol) entered 10 mL vial and a sodium carbonate solution (0.4 mL, 0.200 mmol) was added thereto. Thereafter, a benzoic acid chloride solution (1.0 mL, 0.200 mmol) entered the vial, vigorously shaken and agitated at room temperature for 18 hours. After terminating the reaction, an organic layer was moved to a cartridge tube (6 mL, benzenesulfonic acid, 904030-WJ, UCT) using ethyl acetate. Impurities were removed using methanol (15 mL) while separation and purification were conducted using an elute solution (ethyl acetate/methanol/triethylamine, 20:2:1, v/v/v), resulting in a benzamide compound represented by Formula 13 as a desired product (VVZ-014; 66 mg, 83percent yield). Analysis data of the produced benzamide compound is provided as follows. 1H-NMR (MeOD-d4) d 1.22 (t, 3H), 1.73 (m, 1H), 1.80 (m, 2H), 1.98 (m, 1H), 2.30 (m, 1H), 2.41 (m, 1H), 2.76 (m, 1H), 3.02 (m, 1H), 3.28 (m, 2H), 3.65 (dd, 1H), 3.88 (s, 6H), 5.02 (s, 2H), 7.17-7.46 (m, 7H)
The synthetic route of 22795-99-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Lee, Doo Hyun; US2014/336378; (2014); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare