As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO311,mainly used in chemical industry, its synthesis route is as follows.,14098-24-9
General procedure: A modification of the previously reported procedure23 was used. Commercially available Eaton’s reagent (ca. 8 ml that corresponds to 6.28 mmol of phosphorus(V) oxide) and acetic acid (0.20 ml, 3.45 mmol) were mixed at room temperature. Then naphtho-15-crown-5 ether (1 g, 3.14 mmol) was added. The reaction mixture was stirred at room temperature for ca. 6 h and then poured into water. The suspension was extracted with dichloromethane and the combined organic phases were washed with water. Removal of the dried (MgSO4) solvent gave a dark brown oil, which upon repeated extractions with hot heptane, afforded the product as an off-white solid (1.02 g, 90%), mp 126-129 C.
With the synthetic route has been constantly updated, we look forward to future research findings about Benzo-18-crown 6-Ether,belong chiral-catalyst compound
Reference£º
Article; Paramonov, Sergey V.; Lokshin, Vladimir; Smolentsev, Artem B.; Glebov, Evgeni M.; Korolev, Valeri V.; Basok, Stepan S.; Lysenko, Konstantin A.; Delbaere, Stephanie; Fedorova, Olga A.; Tetrahedron; vol. 68; 38; (2012); p. 7873 – 7883;,
Chiral Catalysts
Chiral catalysts – SlideShare