As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO415,mainly used in chemical industry, its synthesis route is as follows.,14098-24-9
For example, the co-crystal compound of the present invention can be prepared by an anti-solvent method, and the specific implementation is described below. With reference to FIG. 2 for a schematic view of preparing a co-crystal compound of the present invention, the same mole of ammonium nitrate (NH4NO3) and benzo-18-crown-6-ether (C16H24O6) are prepared and added into a glass reactor 200. In this preferred embodiment, the quantities of both ammonium nitrate and benzo-18-crown-6-ether are equal to 0.048 mole, and then a 25 ml pipette 210 is used to titrate approximately 31 ml of methanol (MeOH) in the glass reactor 200. A water bath takes place in the glass reactor 200 in a water tank at 25 C., and a blender 220 is provided for blending at 250 rpm for two hours., and finally the 25 ml pipette 210 is used for titrate methyl tertiary butyl ether into the glass reactor 200 slowly. Now, the solution in the glass reactor 200 becomes turbid gradually, and then we can wait for the formation of the co-crystal compound of the present invention.
With the synthetic route has been constantly updated, we look forward to future research findings about Benzo-18-crown 6-Ether,belong chiral-catalyst compound
Reference£º
Patent; NATIONAL CENTRAL UNIVERSITY; Tu, Lee; Chen, Jeng-Wei; US2013/102797; (2013); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare