Downstream synthetic route of (S)-2-(Methoxymethyl)pyrrolidine

With the complex challenges of chemical substances, we look forward to future research findings about (S)-2-(Methoxymethyl)pyrrolidine,belong chiral-catalyst compound

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO169,mainly used in chemical industry, its synthesis route is as follows.,63126-47-6

(S)- (+)-2- (METHOXYMETHYL) PYRROLIDINE (320 P1L, 2.59 mmol) was added to a stirred solution OF 4- (2-BROMO-ETHYL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ester from Step 2 (797 mg, 2.44 mmol) and TEA (360 RL, 2.58 mmol) in acetonitrile (12 mL). The yellow solution was stirred overnight at rt and concentrated under reduced pressure. The crude residue was diluted with EtOAc, washed with saturated sodium bicarbonate solution and brine, and dried with magnesium sulfate. The solvent was removed to give 591 mg (67percent) of (S)-4- [2- (2-methoxymethyl-pyrrolidin-l-yl)-ethyl]-piperidine-l-carboxylicacid benzyl ester as a yellow oil. MS (ES+) M/Z 361 (M+H).

With the complex challenges of chemical substances, we look forward to future research findings about (S)-2-(Methoxymethyl)pyrrolidine,belong chiral-catalyst compound

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/5397; (2005); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare