The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Name: H-SER-ILE-LYS-VAL-ALA-VAL-OH, 146439-94-3, Name is H-SER-ILE-LYS-VAL-ALA-VAL-OH, SMILES is O=C(O)[C@H](C(C)C)NC([C@H](C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@@H](N)CO)=O)=O)=O)=O)=O, in an article , author is Kam, Mei Kee, once mentioned of 146439-94-3.
Chiral tertiary alpha-hydroxyketones were synthesized with high enantiopurity by asymmetric decarboxylative chlorination and subsequent nucleophilic substitution. We recently reported the asymmetric decarboxylative chlorination of beta-ketocarboxylic acids in the presence of a chiral primary amine catalyst to obtain alpha-chloroketones with high enantiopurity. Here, we found that nucleophilic substitution of the resulting alpha-chloroketones with tetrabutylammonium hydroxide yielded the corresponding alpha-hydroxyketones without loss of enantiopurity. The reaction proceeded smoothly even at a tertiary carbon. The proposed method would be useful for the preparation of chiral tertiary alcohols.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 146439-94-3, you can contact me at any time and look forward to more communication. Name: H-SER-ILE-LYS-VAL-ALA-VAL-OH.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare