Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 4488-22-6, Name is [1,1′-Binaphthalene]-2,2′-diamine. In a document type is Article, introducing its new discovery., 4488-22-6
An Asymmetric Synthesis of Lactones from Cyclic Acid Anhydrides with Chiral Binaphthyldiamines
Asymmetric ring opening of the cyclic acid anhydrides cis-2,3-6 with the axially dissymmetric binaphthyldiamines (S)-1a-d and subsequent esterification gave diastereomeric mixtures of the amide-esters 7a-h.Successive reduction of the ester group and ring closure by hydrolysis afforded (-)-cis-2,4-dimethyl-delta-valerolactone (8, 92percent e.e.), (-)-mevalonolactone (9, 58percent e.e.)(+)-3-isopropyl-delta-valerolactone (10, 42percent e.e.), and (+)-2,3-methylene-gamma-butyrolactone (11, 46percent e.e).Through kinetic resolution of the racemic anhydride trans-2, (-)-trans-2,4-dimethyl-delta-valerolactone (12) was yielded in a 74percent e.e., whose absolute configuration was established to be 2R,4R.
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Reference£º
Chiral Catalysts,
Chiral catalysts – SlideShare