Extracurricular laboratory: Discover of Potassium sodium tartrate tetrahydrate

Electric Literature of 6381-59-5, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 6381-59-5.

Electric Literature of 6381-59-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 6381-59-5, Name is Potassium sodium tartrate tetrahydrate, SMILES is O=C([O-])[C@H](O)[C@@H](O)C([O-])=O.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[K+].[Na+], belongs to chiral-catalyst compound. In a article, author is Li, Mao-Lin, introduce new discover of the category.

Although the transition metal-catalyzed asymmetric hydrogenation of aromatic ketones has been extensively explored, the enantioselective hydrogenation of aliphatic ketones remains a challenge because chiral catalysts cannot readily discriminate between the re and si faces of these ketones. Herein, we report a carboxyl-directing strategy for the asymmetric hydrogenation of aliphatic gamma-ketoacids. With catalysis by iridium complexes bearing chiral spiro phosphino-oxazoline ligands, hydrogenation of aliphatic gamma-ketoacids afforded chiral gamma-hydroxylacids with high enantioselectivity (up to 99% ee). Mechanistic studies revealed that the carboxyl group of the substrate directs hydrogen transfer and ensures high enantioselectivity. Density functional theory calculations suggested the occurrence of chiral induction involving a hydrogen-hydrogen interaction between a hydride on the iridium atom and the substituent on the oxazoline ring of the ligand, and on the basis of the calculations, we proposed a catalytic cycle involving only Ir(III), which differs from the Ir(III)/Ir(V) catalytic cycle that operates in the hydrogenation of alpha,beta-unsaturated carboxylic acids.

Electric Literature of 6381-59-5, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 6381-59-5.

Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare