(S)-(1-Ethylpyrrolidin-2-yl)methanamine, cas is 22795-99-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,22795-99-9
49 g of methyl 2-methoxy-5-sulfamoylbenzoate and(S)-1-ethyl-2-aminomethyltetrahydropyrrolidine 26.5gAdd to the reaction bottle,The reaction was carried out at 90 to 100 ¡ã C for 5 hours under nitrogen protection.The reaction was completed, cooled to 80 ¡ã C, 50 g of ethanol was added, and the mixture was stirred and refluxed for 10 minutes.Cool to 5 ¡ã C and stir for 2 hours, filter,It was washed with ethanol and dried at 65 ¡ãC.The yield was 93.8percent, and the purity was 99.2percent.
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Reference£º
Patent; Jiangsu Tianshili Diyi Pharmaceutical Co., Ltd.; Liu Jinping; Liu Wenzheng; Zhu Zhanyuan; Yang Guojun; (5 pag.)CN103804265; (2018); B;,
Chiral Catalysts
Chiral catalysts – SlideShare