(1R,2S)-2-Amino-1,2-diphenylethanol, cas is 23190-16-1, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,23190-16-1
5.0 mL of water and 0.21 mL of 1 N hydrochloric acid was added to 90 mg (0.21 mmol) of a mixture of a sodium salt of (3S)-3-benzyloxycarbonylamino-(R)-1-amino(sulfoamino)phosphinyl-2-piperidone and a sodium salt of (3R)-3-benzyloxycarbonylamino-(S)-1-amino(sulfoamino)phosphinyl-2-piperidone at about 1:1, and 42.6 mg (0.20 mmol) of (1R, 2S)-(-)-2-amino-1,2-diphenylethanol; and the reaction liquid was stirred while being heated. Both compounds were completely dissolved at an inner temperature of about 50C, heating was stopped, and the reaction liquid was left till the inner temperature becomes room temperature. The precipitated crystal was taken through a filter, and 25 mg of a salt of (3R)-3-benzyloxycarbonylamino-(R)-1-amino(sulfoamino) phosphinyl-2-piperidone with (1R,2S)-(-)-2-amino-1,2-diphenylethanol (0.040 mmol, an optical purity (d.e.) of 95%, and a yield of 19%) was obtained. salt of (3R)-3-benzyloxycarbonylamino-(R)-1-amino(sulfoamino)phosphinyl-2-piperidone with (1R,2S)-(-)-2-amino-1,2-diphenylethanol1H-NMR (200MHzFT, TMS, CD3OD) 1.63-2.02 (3H, m), 2.12-2.30 (1H, m), 3.50-3.88 (2H, m), 4.17-4.30 (1H, m), 4.46 (1H, d, J=4.0 Hz), 5.08 (2H, s), 5.22 (1H, d, J=4.0 Hz), 7.04-7.41 (15H, m)
As the rapid development of chemical substances, we look forward to future research findings about 23190-16-1
Reference£º
Patent; Nippon Kayaku Kabushiki Kaisha; ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI; EP1457494; (2004); A1;,
Chiral Catalysts
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