Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, is researched, Molecular C12H10ClNO3, CAS is 43142-76-3, about Synthesis of some diazocino, diazepino and pyridazinoindoles.Computed Properties of C12H10ClNO3.
The trials and method used for the synthesis of diazocino[6,7-b]indoles (I, R, R1 = H, Me; X = H, Cl) by reacting aldehydic indole esters with o-phenylenediamines are described. [1,2]Diazepino[4,5-b]indoles (II, R = H, Me) were obtained from hydrazinolysis of the oxopropyl derivatives which were in turn produced by reductive hydrolysis of nitrovinylindoles. Pyridazino[4,5-b]indoles (III, R = H, Me), were prepared either via hydrazinolysis of 3-cyano-2-ethoxy-carbonylindoles to produce the intermediates 3-cyano-2-hydrazinocarbonylindoles followed by cyclization, or directly by heating 3-cyano-2-ethoxy-carbonylindoles with hydrazine. Condensation of the indole carboxyaldehyde with some aromatic amines yielded the Schiff bases.
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