Reference of 21436-03-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 21436-03-3, C6H14N2. A document type is Article, introducing its new discovery.
Asymmetric synthesis of (-)-anatoxin-a via an asymmetric cyclization using a new ligand for Pd-catalyzed alkylations
Palladium-catalyzed asymmetric allylic alkylations have been explored in the context of medium-sized ring substrates, intramolecular vs intermolecular processes involving attack on a formally meso pi-allyl intermediate in the desymmetrization, and the presence of electron-withdrawing groups on the cationic pi-allylpalladium intermediate. The synthesis of anatoxin-a, also known as the ‘very fast death factor’, raises all of these questions. Ligands derived from trans-1,2-diaminocyclohexane and 2-diphenylphosphinobenzoic acid effect asymmetric alkylations with an allyl substrate bearing an electron- withdrawing group. On the other hand, a new type of ligand wherein the diamine is derivatized with both 2-diphenylphosphinobenzoic acid and 2- picolinic acid was required to effect asymmetric cyclization to form the 9- azabicyclo[4.2.1]non-2-ene system. A total synthesis of anatoxin-a from 5- hydroxy-1,8-nonadiene employing a metathesis reaction to form the cycloheptene and a palladium-catalyzed asymmetric cyclization to form the bicyclic ring system is achieved in 15% overall yield.
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Chiral Catalysts,
Chiral catalysts – SlideShare