Application of 94-93-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 94-93-9, Name is 2,2′-((Ethane-1,2-diylbis(azanylylidene))bis(methanylylidene))diphenol, SMILES is OC1=CC=CC=C1C=NCCN=CC2=CC=CC=C2O, belongs to chiral-catalyst compound. In a article, author is Huang, Xin, introduce new discover of the category.
In this manuscript, a simple and efficient sulfa-Michael addition reaction of aryl thiols to trisubstituted alpha-fluoro-alpha,beta-unsaturated esters both in racemic and, for the first time, in enantioselective version is reported. The commercially available dimer of cinchona derivatives (DHQ)(2)PYR was used as a catalyst. This strategy showed a great tolerance for various substrates and substituents, providing fair to excellent yields, moderate to excellent diastereoselectivities (2:1 to >99:1), and low to good enantioselectivities (2 to 87%). The reaction has been applied to the synthesis of fluorinated analogues of diltiazem and tiazesim, both therapeutic agents.
Application of 94-93-9, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 94-93-9.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare