Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 6645-46-1, Name is (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride, molecular formula is C7H16ClNO3, belongs to chiral-catalyst compound, is a common compound. In a patnet, author is Liu, Yuanhua, once mentioned the new application about 6645-46-1, Application In Synthesis of (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride.
Cheap transition metal Ni-catalyzed asymmetric hydrogenation of 2-oxazolones was successfully developed, which provided an efficient synthetic strategy to prepare various chiral 2-oxazolidinones with 95%-99% yields and 97%->99% ee. The gram-scale hydrogenation could be proceeded well with >99% ee in the presence of low catalyst loading (up to 3350 TON). This Ni-catalyzed hydrogenation protocol demonstrated great synthetic utility, and the chiral 2-oxazolidinone product was easily converted to a variety of other important molecules in good yields and without loss of ee values, such as chiral dihydrothiophene-2(3H)-thione, amino alcohol, oxazoline ligand, and allenamide. Moreover, a series of deuterium labeling experiments, control experiments, and DFT calculations were conducted to illustrate a reasonable catalytic mechanism for this Ni-catalyzed asymmetric hydrogenation, which involved a tautomerization between the enamine and its isomer imine and then went through asymmetric 1,2-addition of Ni(II)-H to the preferred imine.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 6645-46-1. The above is the message from the blog manager. Application In Synthesis of (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare