Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 10466-61-2, is researched, SMILESS is N[C@@H](CC(C)C)C(N)=O.[H]Cl, Molecular C6H15ClN2OJournal, Article, Amino Acids called Specific recognition of a tetrahedral phosphonamidate transition state analog group by a recombinant antibody Fab fragment, Author is Hua, T. D.; Lamaty, F.; Souriau, C.; Rolland-Fulcrand, V.; Lazaro, R.; Viallefont, P.; Lefranc, M.-P.; Weill, M., the main research direction is peptide synthesis antibody Fab phosphonamidate hapten.SDS of cas: 10466-61-2.
In order to obtain antibodies able to catalyze a peptide synthesis, a naive combinatorial library of human Fab antibody fragments was screened with the phosphonamidate transition state analog of the reaction. Several Fab fragments were able to bind the analog. Competitive binding studies performed with mols. containing representative parts of the hapten showed that two Fabs were able to recognize specifically the tetrahedral phosphorus present in the hapten.
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