HPLC of Formula: 43142-76-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, is researched, Molecular C12H10ClNO3, CAS is 43142-76-3, about Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid CB1 Receptor. Author is Piscitelli, Francesco; Ligresti, Alessia; La Regina, Giuseppe; Coluccia, Antonio; Morera, Ludovica; Allara, Marco; Novellino, Ettore; Di Marzo, Vincenzo; Silvestri, Romano.
New N-phenylethyl-1H-indole-2-carboxamides as the first SAR study of allosteric modulators of the CB1 receptor were synthesized. The presence of the carboxamide functionality was required in order to obtain a stimulatory effect. The maximum stimulatory activity on CB1 was EC50 = 50 nM.
There is still a lot of research devoted to this compound(SMILES：O=C(C(N1)=C(C=O)C2=C1C=CC(Cl)=C2)OCC)HPLC of Formula: 43142-76-3, and with the development of science, more effects of this compound(43142-76-3) can be discovered.